UniProtKB - Q0VF55 (Q0VF55_MOUSE)
Protein
Calcium-transporting ATPase
Gene
Atp2b3
Organism
Mus musculus (Mouse)
Status
Functioni
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
Catalytic activityi
- EC:7.2.2.10UniRule annotationARBA annotation
GO - Molecular functioni
- ATPase-coupled cation transmembrane transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- calcium ion transmembrane transporter activity Source: MGI
- calcium transmembrane transporter activity, phosphorylative mechanism Source: GO_Central
- calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration Source: MGI
- metal ion binding Source: UniProtKB-KW
- PDZ domain binding Source: MGI
GO - Biological processi
- calcium ion export across plasma membrane Source: MGI
- cellular calcium ion homeostasis Source: GO_Central
- regulation of cytosolic calcium ion concentration Source: MGI
Keywordsi
Molecular function | TranslocaseARBA annotation |
Biological process | Calcium transportUniRule annotationARBA annotation, Ion transport, Transport |
Ligand | ATP-bindingUniRule annotationARBA annotation, Calcium, MagnesiumARBA annotation, Metal-bindingARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-418359, Reduction of cytosolic Ca++ levels R-MMU-5578775, Ion homeostasis R-MMU-936837, Ion transport by P-type ATPases |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Atp2b3Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1347353, Atp2b3 |
Subcellular locationi
Other locations
- Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Plasma Membrane
- integral component of presynaptic membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- GABA-ergic synapse Source: MGI
- glutamatergic synapse Source: MGI
- intracellular membrane-bounded organelle Source: GO_Central
- membrane raft Source: MGI
- parallel fiber to Purkinje cell synapse Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 376 – 397 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 417 – 443 | HelicalUniRule annotationAdd BLAST | 27 | |
Transmembranei | 933 – 951 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 971 – 988 | HelicalUniRule annotationAdd BLAST | 18 | |
Transmembranei | 1000 – 1025 | HelicalUniRule annotationAdd BLAST | 26 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSMUSG00000031376, Expressed in cerebellar cortex and 83 other tissues |
Interactioni
GO - Molecular functioni
- PDZ domain binding Source: MGI
Protein-protein interaction databases
IntActi | Q0VF55, 1 interactor |
STRINGi | 10090.ENSMUSP00000085775 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 50 – 126 | Cation_ATPase_NInterPro annotationAdd BLAST | 77 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 22 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 298 – 354 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 1166 – 1187 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1201 – 1220 | DisorderedSequence analysisAdd BLAST | 20 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1076 – 1103 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 337 – 354 | PolyampholyteSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]UniRule annotation
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG0204, Eukaryota |
GeneTreei | ENSGT00940000160765 |
OrthoDBi | 115892at2759 |
TreeFami | TF300330 |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR030325, ATP2B3 IPR022141, ATP_Ca_trans_C IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006408, P-type_ATPase_IIB IPR001757, P_typ_ATPase |
PANTHERi | PTHR24093:SF284, PTHR24093:SF284, 1 hit |
Pfami | View protein in Pfam PF12424, ATP_Ca_trans_C, 1 hit PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01517, ATPase-IIB_Ca, 1 hit TIGR01494, ATPase_P-type, 3 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q0VF55-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDMANSSIE FHPKPQQQRE VPHVGGFGCT LAELRSLMEL RGAEALQKIQ
60 70 80 90 100
EAYGDVSGLC RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ
110 120 130 140 150
LVWEALQDVT LIILEVAAIV SLGLSFYAPP GEESEACGNV SGGAEDEGEA
160 170 180 190 200
EAGWIEGAAI LLSVICVVLV TAFNDWSKEK QFRGLQSRIE QEQKFTVIRN
210 220 230 240 250
GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQGNDLKID ESSLTGESDH
260 270 280 290 300
VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE
310 320 330 340 350
KKDKKGKQQD GAMDSSQTRA KKQDGAVAME MQPLKSAEGG EMEEREKKKA
360 370 380 390 400
NVPKKEKSVL QGKLTKLAVQ IGKAGLVMSA ITVIILVLYF VIETFVVDGR
410 420 430 440 450
VWLAECTPVY VQYFVKFFII GVTVLVVAVP EGLPLAVTIS LAYSVKKMMK
460 470 480 490 500
DNNLVRHLDA CETMGNATAI CSDKTGTLTT NRMTVVQSYL GDTHYKEIPA
510 520 530 540 550
PSALTPKILD LLVHAISINS AYTTKILPPE KEGALPRQVG NKTECALLGF
560 570 580 590 600
VLDLKRDFQP VREQIPEDQL YKVYTFNSVR KSMSTVIRMP DGGFRLFSKG
610 620 630 640 650
ASEILLKKCT NILNSNGELR GFRPRDRDDM VKKIIEPMAC DGLRTICIAY
660 670 680 690 700
RDFSAIQEPD WDNENEVVGD LTCIAVVGIE DPVRPEVPEA IRKCQRAGIT
710 720 730 740 750
VRMVTGDNIN TARAIAAKCG IIQPGEDFLC LEGKEFNRRI RNEKGEIEQE
760 770 780 790 800
RLDKVWPKLR VLARSSPTDK HTLVKGIIDS TTGEQRQVVA VTGDGTNDGP
810 820 830 840 850
ALKKADVGFA MGIAGTDVAK EASDIILTDD NFTSIVKAVM WGRNVYDSIS
860 870 880 890 900
KFLQFQLTVN VVAVIVAFTG ACITQDSPLK AVQMLWVNLI MDTFASLALA
910 920 930 940 950
TEPPTESLLL RKPYGRDKPL ISRTMMKNIL GHAVYQLTII FTLLFVGELF
960 970 980 990 1000
FDIDSGRNAP LHSPPSEHYT IIFNTFVMMQ LFNEINARKI HGERNVFDGI
1010 1020 1030 1040 1050
FSNPIFCTIV LGTFGIQIVI VQFGGKPFSC SPLSTEQWLW CLFVGVGELV
1060 1070 1080 1090 1100
WGQVIATIPT SQLKCLKEAG HGPGKDEMTD EELAEGEEEI DHAERELRRG
1110 1120 1130 1140 1150
QILWFRGLNR IQTQIRVVKA FRSSLYEGLE KPESKSCIHN FMATPEFLIN
1160 1170 1180 1190 1200
DYTHNIPLID DTDVDENEER LRAPPPPPPN QNNNAIDSGI YLTTHATKSA
1210 1220
TSSAFSSRPG SPLHSMETSL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2ALL9 | A2ALL9_MOUSE | Calcium-transporting ATPase | Atp2b3 | 1,173 | Annotation score: | ||
Q8C048 | Q8C048_MOUSE | Calcium-transporting ATPase | Atp2b3 | 1,144 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL732461 Genomic DNA No translation available. AL805924 Genomic DNA No translation available. BC118975 mRNA Translation: AAI18976.1 |
RefSeqi | NP_796210.2, NM_177236.4 |
Genome annotation databases
Ensembli | ENSMUST00000088429; ENSMUSP00000085775; ENSMUSG00000031376 |
GeneIDi | 320707 |
UCSCi | uc009tlz.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL732461 Genomic DNA No translation available. AL805924 Genomic DNA No translation available. BC118975 mRNA Translation: AAI18976.1 |
RefSeqi | NP_796210.2, NM_177236.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q0VF55, 1 interactor |
STRINGi | 10090.ENSMUSP00000085775 |
Protocols and materials databases
Antibodypediai | 443, 67 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000088429; ENSMUSP00000085775; ENSMUSG00000031376 |
GeneIDi | 320707 |
UCSCi | uc009tlz.2, mouse |
Organism-specific databases
CTDi | 492 |
MGIi | MGI:1347353, Atp2b3 |
Phylogenomic databases
eggNOGi | KOG0204, Eukaryota |
GeneTreei | ENSGT00940000160765 |
OrthoDBi | 115892at2759 |
TreeFami | TF300330 |
Enzyme and pathway databases
Reactomei | R-MMU-418359, Reduction of cytosolic Ca++ levels R-MMU-5578775, Ion homeostasis R-MMU-936837, Ion transport by P-type ATPases |
Miscellaneous databases
BioGRID-ORCSi | 320707, 3 hits in 18 CRISPR screens |
ChiTaRSi | Atp2b3, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031376, Expressed in cerebellar cortex and 83 other tissues |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR030325, ATP2B3 IPR022141, ATP_Ca_trans_C IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006408, P-type_ATPase_IIB IPR001757, P_typ_ATPase |
PANTHERi | PTHR24093:SF284, PTHR24093:SF284, 1 hit |
Pfami | View protein in Pfam PF12424, ATP_Ca_trans_C, 1 hit PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01517, ATPase-IIB_Ca, 1 hit TIGR01494, ATPase_P-type, 3 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q0VF55_MOUSE | |
Accessioni | Q0VF55Primary (citable) accession number: Q0VF55 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 5, 2006 |
Last sequence update: | September 5, 2006 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |