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Entry version 86 (18 Sep 2019)
Sequence version 2 (26 Nov 2014)
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Protein

Uncharacterized protein KIAA2012

Gene

KIAA2012

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein KIAA2012Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIAA2012Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:51250 KIAA2012

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q0VF49

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KIAA2012

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121940491

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003322001 – 1180Uncharacterized protein KIAA2012Add BLAST1180

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q0VF49

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q0VF49

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q0VF49

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q0VF49

PeptideAtlas

More...
PeptideAtlasi
Q0VF49

PRoteomics IDEntifications database

More...
PRIDEi
Q0VF49

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58831 [Q0VF49-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q0VF49

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q0VF49

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182329 Expressed in 45 organ(s), highest expression level in right uterine tube

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q0VF49 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000437957

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili988 – 1171Sequence analysisAdd BLAST184

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQDB Eukaryota
ENOG410Y0AJ LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q0VF49

Database of Orthologous Groups

More...
OrthoDBi
668013at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031440 DUF4670

The PANTHER Classification System

More...
PANTHERi
PTHR21937 PTHR21937, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15709 DUF4670, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q0VF49-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFTLSLLSRG HGKLGQDKQK LEVYFEPEDY LNWRSPEDYV PVSKPQDKNN
60 70 80 90 100
ASQHSWSLFL PKTFSTRKGA LILYSEGFAI SAWTPKERRK GPYCPRGPWR
110 120 130 140 150
KLDLELHTLQ DLKEAILAYG RQQGEQDRAW QPYLHFRSQL ESQAQRQIQP
160 170 180 190 200
GHSAKRYLRG LLRTWPPDAM YRLWCAGYIK DSVLLQDSQL NVPKKLRPQQ
210 220 230 240 250
DLSGVPPKYH LLPVFPSFWI QQGKSFEQRQ QGLDEGEAGA AGHVDQGPLA
260 270 280 290 300
KNHGSQGTRL PPRRKQPWQE DETQAEDTSI ENHLCLYASK ESYNEKTQQT
310 320 330 340 350
SRKAFGHGRI DHSWLPSDKS HITFCGGAFP NRKADLSDKQ RNVKLHKARS
360 370 380 390 400
SHLLQVLPAE RSLFPPVASA TGSRIITPGE VKKKKAPKAL KLPPISEEPP
410 420 430 440 450
RVLEPLKSQF KANEPPTELF ILPVEIHYHT KQPPKEKAHR RGAPHPESEP
460 470 480 490 500
ESSEESTPVW RPPLKHASLE TPWELTVHLP VDASRDTLSP QGSSSLPPAS
510 520 530 540 550
LGNLTLKGSK ARHTRVHSQG KGVWKGDDDA PPHDVAPPLD LLPPIKGKKS
560 570 580 590 600
PESQKGVDSP RTSDHNSPPS LPNMRVPRRA LPAAQEDSSD PTLGHFLLGP
610 620 630 640 650
DGEKVCLSLP GHTQTEALPS GKAYESVNSN ISHEEEGPSS QHFLKANTEP
660 670 680 690 700
RANLHMNLYE TSPLTQTTEK QGAQQSLEAA AQKTGEPQSC INKALICSNR
710 720 730 740 750
KEFYTRKLHI DMTPFLKESG NALDYQEEAG RPLRETHHND QDPEPRSMTL
760 770 780 790 800
DSPRASRTEH IQTPEADIVQ KVGRDYDVHH LHRGLLGYGP ESPERLSAVY
810 820 830 840 850
TSLLPREREG KAEPRLFSQE TSANISHERD LINEAKRKEK PKKDKTKGPK
860 870 880 890 900
SEREGKVYGQ AEAAIGKSKD SKAKKKLEKK TRPQRKRTQK ERNLEIAAEL
910 920 930 940 950
SGPDVSYEET EDTSNRGSFA SDSFVEDPWL SPKYDAQESQ VSLDGRSSPS
960 970 980 990 1000
QIATVTGNME SKEERRCEDP SKALLTKREQ EKASWDRLRA ERAEMRWLEV
1010 1020 1030 1040 1050
EKKRREQEEQ RQLQQEQLER AKKMEEELEL EQQRRTEEIR LRKQRLQEEQ
1060 1070 1080 1090 1100
QRQEEEERKQ QLRLKAAQER ARQQQEEFRR KLRELQRKKQ QEEAERAEAE
1110 1120 1130 1140 1150
KQRQEELEMQ LEEEQKHLME MAEEERLEYQ RRKQEAEEKA RLEAEERRQK
1160 1170 1180
EEEAARLALE EATKQAQEQA RYWIFGQQLP
Length:1,180
Mass (Da):135,305
Last modified:November 26, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3DD908BD7D101BC
GO
Isoform 2 (identifier: Q0VF49-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-627: Missing.
     628-645: NSNISHEEEGPSSQHFLK → MRSRSDHLDLFSSLIFTT

Note: No experimental confirmation available.Curated
Show »
Length:553
Mass (Da):65,141
Checksum:iB5A290EF3C25C1E0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C5G6H7C5G6_HUMAN
Uncharacterized protein KIAA2012
KIAA2012
1,181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GV91A0A1B0GV91_HUMAN
Uncharacterized protein KIAA2012
KIAA2012
599Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC23108 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0571401 – 627Missing in isoform 2. Add BLAST627
Alternative sequenceiVSP_057141628 – 645NSNIS…QHFLK → MRSRSDHLDLFSSLIFTT in isoform 2. Add BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB095932 mRNA Translation: BAC23108.1 Different initiation.
AC069148 Genomic DNA No translation available.
AC079354 Genomic DNA No translation available.
BC118982 mRNA Translation: AAI18983.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000541917; ENSP00000437957; ENSG00000182329

UCSC genome browser

More...
UCSCi
uc031rqt.1 human [Q0VF49-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB095932 mRNA Translation: BAC23108.1 Different initiation.
AC069148 Genomic DNA No translation available.
AC079354 Genomic DNA No translation available.
BC118982 mRNA Translation: AAI18983.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000437957

PTM databases

iPTMnetiQ0VF49
PhosphoSitePlusiQ0VF49

Polymorphism and mutation databases

BioMutaiKIAA2012
DMDMi121940491

Proteomic databases

EPDiQ0VF49
jPOSTiQ0VF49
MassIVEiQ0VF49
PaxDbiQ0VF49
PeptideAtlasiQ0VF49
PRIDEiQ0VF49
ProteomicsDBi58831 [Q0VF49-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000541917; ENSP00000437957; ENSG00000182329
UCSCiuc031rqt.1 human [Q0VF49-1]

Organism-specific databases

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KIAA2012
HGNCiHGNC:51250 KIAA2012
neXtProtiNX_Q0VF49

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQDB Eukaryota
ENOG410Y0AJ LUCA
InParanoidiQ0VF49
OrthoDBi668013at2759

Miscellaneous databases

Pharos

More...
Pharosi
Q0VF49

Protein Ontology

More...
PROi
PR:Q0VF49

Gene expression databases

BgeeiENSG00000182329 Expressed in 45 organ(s), highest expression level in right uterine tube
GenevisibleiQ0VF49 HS

Family and domain databases

InterProiView protein in InterPro
IPR031440 DUF4670
PANTHERiPTHR21937 PTHR21937, 1 hit
PfamiView protein in Pfam
PF15709 DUF4670, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK2012_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0VF49
Secondary accession number(s): Q8IVF9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 26, 2014
Last modified: September 18, 2019
This is version 86 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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