Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Centrosomal protein of 76 kDa

Gene

Cep76

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 76 kDa
Short name:
Cep76
Gene namesi
Name:Cep76
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1923401 Cep76

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789491 – 659Centrosomal protein of 76 kDaAdd BLAST659

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ0VEJ0
MaxQBiQ0VEJ0
PaxDbiQ0VEJ0
PeptideAtlasiQ0VEJ0
PRIDEiQ0VEJ0

PTM databases

iPTMnetiQ0VEJ0
PhosphoSitePlusiQ0VEJ0

Expressioni

Gene expression databases

BgeeiENSMUSG00000073542 Expressed in 220 organ(s), highest expression level in cerebellum
GenevisibleiQ0VEJ0 MM

Interactioni

Subunit structurei

Interacts with CCP110 and CEP97.By similarity

Protein-protein interaction databases

BioGridi230419, 19 interactors
IntActiQ0VEJ0, 19 interactors
STRINGi10090.ENSMUSP00000095149

Structurei

3D structure databases

ProteinModelPortaliQ0VEJ0
SMRiQ0VEJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CEP76 family.Curated

Phylogenomic databases

eggNOGiENOG410IFDB Eukaryota
ENOG410XWNZ LUCA
GeneTreeiENSGT00390000000781
HOGENOMiHOG000008143
InParanoidiQ0VEJ0
KOiK16457
OMAiPKQPVCF
OrthoDBiEOG091G02SF
PhylomeDBiQ0VEJ0
TreeFamiTF329324

Family and domain databases

InterProiView protein in InterPro
IPR028926 CEP76-C2
IPR038765 Papain_like_cys_pep_sf
PfamiView protein in Pfam
PF15627 CEP76-C2, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit

Sequencei

Sequence statusi: Complete.

Q0VEJ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLPPEKASE LKQLIHQQLS KMDVHGRIRE ILAETIREEL APDQQHLSTE
60 70 80 90 100
DLIKALRRRG IIDDVMKELN FVTDSVDQEL PSSPKQTVGF DKQSTLKKTN
110 120 130 140 150
VDPTRRYLYL QVLGGKAFLE HLQEPEPLPG QICSTFTLCL HYRNQRFRSK
160 170 180 190 200
PVPCACEPDF HDGFLLEVHR ESLGDGTRMA DSTTMLSISD PIHMVLIKTD
210 220 230 240 250
IFGETTLVAS YFLEWRSVLG SENGVTNLTV ELMGVGTESK VSVGILNIKL
260 270 280 290 300
EMYPPLSQTL SQEVVNTQLA LERQKTAEKE RLFLVYAKQW WREYLQIRPS
310 320 330 340 350
HNSRLVKIFA QDENGINRPV CSYVKPLRAG RLLDTPRQAA RFVNVLGYER
360 370 380 390 400
APVIGGGGKQ EQWCTLLAFL CRNKGDCEDH ANLLCSLLLG YGLEAFVCVG
410 420 430 440 450
TKAKGAPHAW VMTCGTDGTI MFWESLTGHR YIHKPTNPDG PPLAEQPKPL
460 470 480 490 500
YPYRTIGCVF NHQMFLGNCQ PSDAVETCIF DLNDESKWKP MSEEAIKSVC
510 520 530 540 550
APGATTSLPP FPPLCASTID ASVTSNEIEM QLRLLVSEHR KDLGLTTVWE
560 570 580 590 600
DQLSYLLSPA LASYEFERTT SISAGNEEFQ DAIRRAVPDG HTFKGFPIHF
610 620 630 640 650
VYRNARRAFA TCLRSPFCEE IICCRGDQVR LAVRVRVFTY PESACAVWIM

FACKYRSVL
Length:659
Mass (Da):74,303
Last modified:September 5, 2006 - v1
Checksum:i658CF10C0C3A74B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466528 Genomic DNA Translation: EDL09636.1
BC119216 mRNA Translation: AAI19217.1
BC119218 mRNA Translation: AAI19219.1
CCDSiCCDS37850.1
RefSeqiNP_001074542.1, NM_001081073.1
UniGeneiMm.111928

Genome annotation databases

EnsembliENSMUST00000097542; ENSMUSP00000095149; ENSMUSG00000073542
GeneIDi225659
KEGGimmu:225659
UCSCiuc008fmq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466528 Genomic DNA Translation: EDL09636.1
BC119216 mRNA Translation: AAI19217.1
BC119218 mRNA Translation: AAI19219.1
CCDSiCCDS37850.1
RefSeqiNP_001074542.1, NM_001081073.1
UniGeneiMm.111928

3D structure databases

ProteinModelPortaliQ0VEJ0
SMRiQ0VEJ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230419, 19 interactors
IntActiQ0VEJ0, 19 interactors
STRINGi10090.ENSMUSP00000095149

PTM databases

iPTMnetiQ0VEJ0
PhosphoSitePlusiQ0VEJ0

Proteomic databases

EPDiQ0VEJ0
MaxQBiQ0VEJ0
PaxDbiQ0VEJ0
PeptideAtlasiQ0VEJ0
PRIDEiQ0VEJ0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097542; ENSMUSP00000095149; ENSMUSG00000073542
GeneIDi225659
KEGGimmu:225659
UCSCiuc008fmq.1 mouse

Organism-specific databases

CTDi79959
MGIiMGI:1923401 Cep76

Phylogenomic databases

eggNOGiENOG410IFDB Eukaryota
ENOG410XWNZ LUCA
GeneTreeiENSGT00390000000781
HOGENOMiHOG000008143
InParanoidiQ0VEJ0
KOiK16457
OMAiPKQPVCF
OrthoDBiEOG091G02SF
PhylomeDBiQ0VEJ0
TreeFamiTF329324

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Miscellaneous databases

PROiPR:Q0VEJ0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073542 Expressed in 220 organ(s), highest expression level in cerebellum
GenevisibleiQ0VEJ0 MM

Family and domain databases

InterProiView protein in InterPro
IPR028926 CEP76-C2
IPR038765 Papain_like_cys_pep_sf
PfamiView protein in Pfam
PF15627 CEP76-C2, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCEP76_MOUSE
AccessioniPrimary (citable) accession number: Q0VEJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 5, 2006
Last modified: November 7, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again