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Protein

Fez family zinc finger protein 1

Gene

Fezf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri260 – 282C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 423C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Fez family zinc finger protein 1
Gene namesi
Name:Fezf1
Synonyms:Fez
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1920441 Fezf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Null mutants were born alive but most of them died within one day. The olfactory bulbs were smaller than those of their wild-type at E18.5 and at postnatal day 0. At E14.5 and E18 no abnormalities in the morphology of the telencephalon or diencephalon were detected. There seems to be a redundant role for FEZF1 and FEZF2 in diencephalon development.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951151 – 475Fez family zinc finger protein 1Add BLAST475

Proteomic databases

PaxDbiQ0VDQ9
PRIDEiQ0VDQ9

PTM databases

iPTMnetiQ0VDQ9
PhosphoSitePlusiQ0VDQ9

Expressioni

Developmental stagei

At E8.0 expressed in prospective forebrain region. At E12.5, detected in the olfactory epithelium, septum, roof of the telencephalon, amygdala, prethalamus and hypothalamus. Expression was barely detected in the vomeronasal organs at E12.5. At E15.5, detected weakly in the olfactory epithelium, amygdala and hypothalamusat E15.5. Expression was not detected in the olfactory bulb or in the ganglionic eminences, where the interneuron progenitors of the olfactory bulb are generated.2 Publications

Gene expression databases

BgeeiENSMUSG00000029697 Expressed in 42 organ(s), highest expression level in anterior naris (mouse)
CleanExiMM_FEZF1
GenevisibleiQ0VDQ9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031709

Structurei

3D structure databases

ProteinModelPortaliQ0VDQ9
SMRiQ0VDQ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi28 – 43Engrailed homology 1 repressorAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi433 – 467Pro-richAdd BLAST35

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri260 – 282C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 423C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00740000115096
HOGENOMiHOG000013052
HOVERGENiHBG098441
InParanoidiQ0VDQ9
OMAiCHNATAK
OrthoDBiEOG091G0ISJ
PhylomeDBiQ0VDQ9
TreeFamiTF316780

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequencei

Sequence statusi: Complete.

Q0VDQ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSSCLNATT KMLATAPARG NVMSTSKPLA FSIERIMART PEPKALPVPH
60 70 80 90 100
FLQGAVPKGD PKHSLHLNSS IPCMIPFVPV AYDTNSKAGV NGSEPRKASL
110 120 130 140 150
EVPAPPAVAP SAPAFSCSDL LNCALSLKGD LARDALPLQQ YKLVRPRVVN
160 170 180 190 200
HSSFHAMGAL CYLNRGDGPC HPAASVNIHP VASYFLSSPL HPQPKTYLAE
210 220 230 240 250
RNKLVVPAVE KLPSGVAFKD LSQAQLQHYM KESAQLLSEK IAFKTSDFSR
260 270 280 290 300
GSPNAKPKVF TCEVCGKVFN AHYNLTRHMP VHTGARPFVC KVCGKGFRQA
310 320 330 340 350
STLCRHKIIH TQEKPHKCNQ CGKAFNRSST LNTHTRIHAG YKPFVCEFCG
360 370 380 390 400
KGFHQKGNYK NHKLTHSGEK QFKCNICNKA FHQVYNLTFH MHTHNDKKPF
410 420 430 440 450
TCPTCGKGFC RNFDLKKHVR KLHDSSLGLT RTPTGEPSSD PPPQLQQPPP
460 470
APLPPLQPTL PPPGPLPSGL HQGHQ
Length:475
Mass (Da):52,006
Last modified:September 5, 2006 - v1
Checksum:iA4DC07D1BA3DE2D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178I → M in BAB29221 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014242 mRNA Translation: BAB29221.1
BC119565 mRNA Translation: AAI19566.1
BC119566 mRNA Translation: AAI19567.1
CCDSiCCDS51725.1
RefSeqiNP_082738.1, NM_028462.1
XP_006505238.1, XM_006505175.3
UniGeneiMm.55115

Genome annotation databases

EnsembliENSMUST00000031709; ENSMUSP00000031709; ENSMUSG00000029697
GeneIDi73191
KEGGimmu:73191
UCSCiuc009bbd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014242 mRNA Translation: BAB29221.1
BC119565 mRNA Translation: AAI19566.1
BC119566 mRNA Translation: AAI19567.1
CCDSiCCDS51725.1
RefSeqiNP_082738.1, NM_028462.1
XP_006505238.1, XM_006505175.3
UniGeneiMm.55115

3D structure databases

ProteinModelPortaliQ0VDQ9
SMRiQ0VDQ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031709

PTM databases

iPTMnetiQ0VDQ9
PhosphoSitePlusiQ0VDQ9

Proteomic databases

PaxDbiQ0VDQ9
PRIDEiQ0VDQ9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031709; ENSMUSP00000031709; ENSMUSG00000029697
GeneIDi73191
KEGGimmu:73191
UCSCiuc009bbd.2 mouse

Organism-specific databases

CTDi389549
MGIiMGI:1920441 Fezf1

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00740000115096
HOGENOMiHOG000013052
HOVERGENiHBG098441
InParanoidiQ0VDQ9
OMAiCHNATAK
OrthoDBiEOG091G0ISJ
PhylomeDBiQ0VDQ9
TreeFamiTF316780

Miscellaneous databases

PROiPR:Q0VDQ9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029697 Expressed in 42 organ(s), highest expression level in anterior naris (mouse)
CleanExiMM_FEZF1
GenevisibleiQ0VDQ9 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFEZF1_MOUSE
AccessioniPrimary (citable) accession number: Q0VDQ9
Secondary accession number(s): Q9CXM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: September 5, 2006
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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