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Entry version 89 (23 Feb 2022)
Sequence version 1 (05 Sep 2006)
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Protein

RUN domain-containing protein 1

Gene

Rundc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RUN domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rundc1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2144506, Rundc1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000035007

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002845121 – 615RUN domain-containing protein 1Add BLAST615

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei73PhosphoserineBy similarity1
Modified residuei499PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q0VDN7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q0VDN7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q0VDN7

PRoteomics IDEntifications database

More...
PRIDEi
Q0VDN7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
260958

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q0VDN7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q0VDN7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000035007, Expressed in ear vesicle and 260 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q0VDN7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000042151

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q0VDN7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q0VDN7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini423 – 604RUNPROSITE-ProRule annotationAdd BLAST182

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni15 – 41DisorderedSequence analysisAdd BLAST27
Regioni147 – 180DisorderedSequence analysisAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili76 – 102Sequence analysisAdd BLAST27
Coiled coili163 – 238Sequence analysisAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi154 – 180Basic and acidic residuesSequence analysisAdd BLAST27

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3759, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007311

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020366_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q0VDN7

Identification of Orthologs from Complete Genome Data

More...
OMAi
ASILMQM

Database of Orthologous Groups

More...
OrthoDBi
556116at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q0VDN7

TreeFam database of animal gene trees

More...
TreeFami
TF105949

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.900, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004012, Run_dom
IPR037213, Run_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02759, RUN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00593, RUN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140741, SSF140741, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50826, RUN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q0VDN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATVEVATEL GTVVTAVGPK AKDEEEEEEE EESLPPCETV RWAPVGAVAE
60 70 80 90 100
AGPGAATFSE AAAAEEPGAA PGSPSDATVR TLRRLEAERR QLDSALLALS
110 120 130 140 150
SHFAQVQFRL RQVVRGAPAE QQRLLRELED FAFRGCPHVL GYEGLADPCG
160 170 180 190 200
GDESDVLPGD RPRVRGEDQS EQEKRERLET QREKQKELIL QLKTQLDDLE
210 220 230 240 250
TFAYQEGSYD SLPQSVVLER QRVIIDELIK KLDMNLNEDI SSLSTEELRQ
260 270 280 290 300
RVDAAVAQIV NPVRVKEQLV EQLKTQIRDL EMFISFIQDE VGSPLQTGGH
310 320 330 340 350
CECQASGKVG IGSTRVGGST LPPGPGKAKA EDAKRARETG LHLMRRALAV
360 370 380 390 400
LQIFTVSQLG CATGQIPQTL WQRSQADRDY SHLLKRLEVS VDRVKQLALR
410 420 430 440 450
HQPHDHVITS ANLQDLSLGG KDELTTVVRK ELTVAVRDLL AHGLYASSSG
460 470 480 490 500
MSLVMAPLAC LLPVFSSAPE TMHPWELFVK YYHAKNGRAY VESPARKLSQ
510 520 530 540 550
SFALPIMGDT AVTPKQSLLT AIHLVLTEHD PFKRSADSEL KALVCMALNE
560 570 580 590 600
QRLVSWVNLI CKSGSLIEPH YQPWSYMAHT GFESALNLLS RLSSLKFSLP
610
VDLAVRQLKN IKDAF
Length:615
Mass (Da):67,865
Last modified:September 5, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65DCB4F235CFFF37
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti144G → R in BAE33983 (PubMed:16141072).Curated1
Sequence conflicti174K → E in BAE33983 (PubMed:16141072).Curated1
Sequence conflicti174K → E in AAI19594 (PubMed:15489334).Curated1
Sequence conflicti332D → G in BAC39654 (PubMed:16141072).Curated1
Sequence conflicti449S → A in BAE33983 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK086362 mRNA Translation: BAC39654.1
AK157156 mRNA Translation: BAE33983.1
AL590996 Genomic DNA No translation available.
BC119592 mRNA Translation: AAI19593.1
BC119593 mRNA Translation: AAI19594.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25469.1

NCBI Reference Sequences

More...
RefSeqi
NP_766154.2, NM_172566.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000040561; ENSMUSP00000042151; ENSMUSG00000035007

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
217201

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:217201

UCSC genome browser

More...
UCSCi
uc007lov.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK086362 mRNA Translation: BAC39654.1
AK157156 mRNA Translation: BAE33983.1
AL590996 Genomic DNA No translation available.
BC119592 mRNA Translation: AAI19593.1
BC119593 mRNA Translation: AAI19594.1
CCDSiCCDS25469.1
RefSeqiNP_766154.2, NM_172566.4

3D structure databases

SMRiQ0VDN7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042151

PTM databases

iPTMnetiQ0VDN7
PhosphoSitePlusiQ0VDN7

Proteomic databases

EPDiQ0VDN7
MaxQBiQ0VDN7
PaxDbiQ0VDN7
PRIDEiQ0VDN7
ProteomicsDBi260958

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
17190, 61 antibodies from 18 providers

Genome annotation databases

EnsembliENSMUST00000040561; ENSMUSP00000042151; ENSMUSG00000035007
GeneIDi217201
KEGGimmu:217201
UCSCiuc007lov.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
146923
MGIiMGI:2144506, Rundc1
VEuPathDBiHostDB:ENSMUSG00000035007

Phylogenomic databases

eggNOGiKOG3759, Eukaryota
GeneTreeiENSGT00390000007311
HOGENOMiCLU_020366_0_0_1
InParanoidiQ0VDN7
OMAiASILMQM
OrthoDBi556116at2759
PhylomeDBiQ0VDN7
TreeFamiTF105949

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
217201, 2 hits in 62 CRISPR screens

Protein Ontology

More...
PROi
PR:Q0VDN7
RNActiQ0VDN7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000035007, Expressed in ear vesicle and 260 other tissues
GenevisibleiQ0VDN7, MM

Family and domain databases

Gene3Di1.20.58.900, 1 hit
InterProiView protein in InterPro
IPR004012, Run_dom
IPR037213, Run_dom_sf
PfamiView protein in Pfam
PF02759, RUN, 1 hit
SMARTiView protein in SMART
SM00593, RUN, 1 hit
SUPFAMiSSF140741, SSF140741, 1 hit
PROSITEiView protein in PROSITE
PS50826, RUN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRUND1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0VDN7
Secondary accession number(s): Q0VDN6, Q3U072, Q8C3C0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: September 5, 2006
Last modified: February 23, 2022
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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