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UniProtKB - Q0VDI3 (TM267_HUMAN)

Entry version 101 (10 Feb 2021)
Sequence version 1 (05 Sep 2006)
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Protein

Transmembrane protein 267

Gene

TMEM267

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q0VDI3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 267Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM267Imported
Synonyms:C5orf28
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26139, TMEM267

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q0VDI3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000151881.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		64417

Open Targets

More...OpenTargetsi		ENSG00000151881

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162380004

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q0VDI3, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM267

Domain mapping of disease mutations (DMDM)

More...DMDMi		121940485

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002819211 – 215Transmembrane protein 267Add BLAST215

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q0VDI3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q0VDI3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q0VDI3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q0VDI3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q0VDI3

PeptideAtlas

More...PeptideAtlasi		Q0VDI3

PRoteomics IDEntifications database

More...PRIDEi		Q0VDI3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58829

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000151881, Expressed in thyroid gland and 201 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q0VDI3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q0VDI3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000151881, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122166, 12 interactors

Protein interaction database and analysis system

More...IntActi		Q0VDI3, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000426067

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q0VDI3, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQ1U, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003050

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q0VDI3

Identification of Orthologs from Complete Genome Data

More...OMAi		LCSVLMY

Database of Orthologous Groups

More...OrthoDBi		1326580at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q0VDI3

TreeFam database of animal gene trees

More...TreeFami		TF323520

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026572, TMEM267

The PANTHER Classification System

More...PANTHERi		PTHR13628, PTHR13628, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q0VDI3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASETEKTHA LLQTCSTESL ISSLGLGAFC LVADRLLQFS TIQQNDWLRA 
        60         70         80         90        100
LSDNAVHCVI GMWSWAVVTG IKKKTDFGEI ILAGFLASVI DVDHFFLAGS 
       110        120        130        140        150
MSLKAALTLP RRPFLHCSTV IPVVVLTLKF TMHLFKLKDS WCFLPWMLFI 
       160        170        180        190        200
SWTSHHIRDG IRHGLWICPF GKTSPLPFWL YVIITSSLPH ICSFVMYLTG 
       210 
TRQMMSSKHG VRIDV
Length:215
Mass (Da):24,217
Last modified:September 5, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E18288823B3BDE6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PBX6E9PBX6_HUMAN
Transmembrane protein 267
TMEM267
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAV6D6RAV6_HUMAN
Transmembrane protein 267
TMEM267
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti86L → F in BAB15108 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK025310 mRNA Translation: BAB15108.1
AK315466 mRNA Translation: BAG37853.1
CH471119 Genomic DNA Translation: EAW56061.1
BC063832 mRNA Translation: AAH63832.1
BC013351 mRNA Translation: AAH13351.1
BC119658 mRNA Translation: AAI19659.1
BC119659 mRNA Translation: AAI19660.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3945.1

NCBI Reference Sequences

More...RefSeqi		NP_071928.2, NM_022483.4
XP_005248390.1, XM_005248333.4
XP_005248392.1, XM_005248335.3
XP_006714549.1, XM_006714486.3
XP_011512376.1, XM_011514074.2
XP_011512377.1, XM_011514075.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000397080; ENSP00000380270; ENSG00000151881
ENST00000500337; ENSP00000426067; ENSG00000151881
ENST00000512085; ENSP00000422881; ENSG00000151881

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64417

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:64417

UCSC genome browser

More...UCSCi		uc003jnv.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025310 mRNA Translation: BAB15108.1
AK315466 mRNA Translation: BAG37853.1
CH471119 Genomic DNA Translation: EAW56061.1
BC063832 mRNA Translation: AAH63832.1
BC013351 mRNA Translation: AAH13351.1
BC119658 mRNA Translation: AAI19659.1
BC119659 mRNA Translation: AAI19660.1
CCDSiCCDS3945.1
RefSeqiNP_071928.2, NM_022483.4
XP_005248390.1, XM_005248333.4
XP_005248392.1, XM_005248335.3
XP_006714549.1, XM_006714486.3
XP_011512376.1, XM_011514074.2
XP_011512377.1, XM_011514075.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi122166, 12 interactors
IntActiQ0VDI3, 9 interactors
STRINGi9606.ENSP00000426067

Genetic variation databases

BioMutaiTMEM267
DMDMi121940485

Proteomic databases

EPDiQ0VDI3
jPOSTiQ0VDI3
MassIVEiQ0VDI3
MaxQBiQ0VDI3
PaxDbiQ0VDI3
PeptideAtlasiQ0VDI3
PRIDEiQ0VDI3
ProteomicsDBi58829

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		67211, 28 antibodies

Genome annotation databases

EnsembliENST00000397080; ENSP00000380270; ENSG00000151881
ENST00000500337; ENSP00000426067; ENSG00000151881
ENST00000512085; ENSP00000422881; ENSG00000151881
GeneIDi64417
KEGGihsa:64417
UCSCiuc003jnv.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64417
DisGeNETi64417

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMEM267
HGNCiHGNC:26139, TMEM267
HPAiENSG00000151881, Low tissue specificity
neXtProtiNX_Q0VDI3
OpenTargetsiENSG00000151881
PharmGKBiPA162380004
VEuPathDBiHostDB:ENSG00000151881.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QQ1U, Eukaryota
GeneTreeiENSGT00390000003050
InParanoidiQ0VDI3
OMAiLCSVLMY
OrthoDBi1326580at2759
PhylomeDBiQ0VDI3
TreeFamiTF323520

Enzyme and pathway databases

PathwayCommonsiQ0VDI3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		64417, 3 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TMEM267, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		64417
PharosiQ0VDI3, Tdark

Protein Ontology

More...PROi		PR:Q0VDI3
RNActiQ0VDI3, protein

Gene expression databases

BgeeiENSG00000151881, Expressed in thyroid gland and 201 other tissues
ExpressionAtlasiQ0VDI3, baseline and differential
GenevisibleiQ0VDI3, HS

Family and domain databases

InterProiView protein in InterPro
IPR026572, TMEM267
PANTHERiPTHR13628, PTHR13628, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM267_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0VDI3
Secondary accession number(s): B2RDA6, Q9H6Z2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 5, 2006
Last modified: February 10, 2021
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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