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UniProtKB - Q0VDF9 (HSP7E_HUMAN)

Entry version 119 (10 Feb 2021)
Sequence version 1 (05 Sep 2006)
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Protein

Heat shock 70 kDa protein 14

Gene

HSPA14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.1 Publication

Miscellaneous

Acts as a potent immunoadjuvant, capable to interact with antigen-presenting cells and generating efficient CD8+ T-cell responses. May be used as adjuvant to enhance effect of vaccine G1F/M2, a candidate vaccine against respiratory syncytial virus (RSV), a major respiratory pathogen in newborns (PubMed:18851947). May also be used as adjuvant to prepare antigenic fusion protein for the therapeutics of cancers (PubMed:15930317).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q0VDF9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3371453, Regulation of HSF1-mediated heat shock response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heat shock 70 kDa protein 14
Alternative name(s):
HSP70-like protein 1
Heat shock protein HSP60
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HSPA14
Synonyms:HSP60, HSP70L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29526, HSPA14

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610369, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q0VDF9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000187522.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		51182

Open Targets

More...OpenTargetsi		ENSG00000187522

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134979057

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q0VDF9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HSPA14

Domain mapping of disease mutations (DMDM)

More...DMDMi		121948121

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002899461 – 509Heat shock 70 kDa protein 14Add BLAST509

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q0VDF9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q0VDF9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q0VDF9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q0VDF9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q0VDF9

PeptideAtlas

More...PeptideAtlasi		Q0VDF9

PRoteomics IDEntifications database

More...PRIDEi		Q0VDF9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58825

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q0VDF9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q0VDF9

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q0VDF9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000187522, Expressed in secondary oocyte and 234 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q0VDF9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q0VDF9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000187522, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119358, 41 interactors

Database of interacting proteins

More...DIPi		DIP-62114N

Protein interaction database and analysis system

More...IntActi		Q0VDF9, 24 interactors

Molecular INTeraction database

More...MINTi		Q0VDF9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000367623

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q0VDF9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q0VDF9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0101, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156380

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005965_0_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q0VDF9

Identification of Orthologs from Complete Genome Data

More...OMAi		EGKNSAN

Database of Orthologous Groups

More...OrthoDBi		646813at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q0VDF9

TreeFam database of animal gene trees

More...TreeFami		TF105045

Family and domain databases

Conserved Domains Database

More...CDDi		cd10238, HSPA14-like_NBD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.34.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043129, ATPase_NBD
IPR018181, Heat_shock_70_CS
IPR029047, HSP70_peptide-bd_sf
IPR013126, Hsp_70_fam
IPR042049, HSPA14_NBD

The PANTHER Classification System

More...PANTHERi		PTHR19375, PTHR19375, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00012, HSP70, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100920, SSF100920, 1 hit
SSF53067, SSF53067, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01036, HSP70_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q0VDF9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAIGVHLGC TSACVAVYKD GRAGVVANDA GDRVTPAVVA YSENEEIVGL 
        60         70         80         90        100
AAKQSRIRNI SNTVMKVKQI LGRSSSDPQA QKYIAESKCL VIEKNGKLRY 
       110        120        130        140        150
EIDTGEETKF VNPEDVARLI FSKMKETAHS VLGSDANDVV ITVPFDFGEK 
       160        170        180        190        200
QKNALGEAAR AAGFNVLRLI HEPSAALLAY GIGQDSPTGK SNILVFKLGG 
       210        220        230        240        250
TSLSLSVMEV NSGIYRVLST NTDDNIGGAH FTETLAQYLA SEFQRSFKHD 
       260        270        280        290        300
VRGNARAMMK LTNSAEVAKH SLSTLGSANC FLDSLYEGQD FDCNVSRARF 
       310        320        330        340        350
ELLCSPLFNK CIEAIRGLLD QNGFTADDIN KVVLCGGSSR IPKLQQLIKD 
       360        370        380        390        400
LFPAVELLNS IPPDEVIPIG AAIEAGILIG KENLLVEDSL MIECSARDIL 
       410        420        430        440        450
VKGVDESGAS RFTVLFPSGT PLPARRQHTL QAPGSISSVC LELYESDGKN 
       460        470        480        490        500
SAKEETKFAQ VVLQDLDKKE NGLRDILAVL TMKRDGSLHV TCTDQETGKC 

EAISIEIAS
Length:509
Mass (Da):54,794
Last modified:September 5, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC3B685C7192B95C3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C2A1H7C2A1_HUMAN
Heat shock 70 kDa protein 14
HSPA14
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6V → A in BAF85012 (PubMed:14702039).Curated1
Sequence conflicti15V → E in AAF66640 (PubMed:14592822).Curated1
Sequence conflicti282L → P in AAF17198 (PubMed:10931946).Curated1
Sequence conflicti312I → L in AAF17198 (PubMed:10931946).Curated1
Sequence conflicti350D → G in BAF85012 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03634785A → V in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs374837716Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF143723 mRNA Translation: AAF66640.1
AF112210 mRNA Translation: AAF17198.1
AK292323 mRNA Translation: BAF85012.1
EF444968 Genomic DNA Translation: ACA05969.1
EF444968 Genomic DNA Translation: ACA05970.1
AC069544 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86258.1
BC119690 mRNA Translation: AAI19691.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7103.1

NCBI Reference Sequences

More...RefSeqi		NP_057383.2, NM_016299.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000378372; ENSP00000367623; ENSG00000187522

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51182

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51182

UCSC genome browser

More...UCSCi		uc001inf.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143723 mRNA Translation: AAF66640.1
AF112210 mRNA Translation: AAF17198.1
AK292323 mRNA Translation: BAF85012.1
EF444968 Genomic DNA Translation: ACA05969.1
EF444968 Genomic DNA Translation: ACA05970.1
AC069544 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86258.1
BC119690 mRNA Translation: AAI19691.1
CCDSiCCDS7103.1
RefSeqiNP_057383.2, NM_016299.3

3D structure databases

SMRiQ0VDF9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119358, 41 interactors
DIPiDIP-62114N
IntActiQ0VDF9, 24 interactors
MINTiQ0VDF9
STRINGi9606.ENSP00000367623

PTM databases

iPTMnetiQ0VDF9
PhosphoSitePlusiQ0VDF9
SwissPalmiQ0VDF9

Genetic variation databases

BioMutaiHSPA14
DMDMi121948121

Proteomic databases

EPDiQ0VDF9
jPOSTiQ0VDF9
MassIVEiQ0VDF9
MaxQBiQ0VDF9
PaxDbiQ0VDF9
PeptideAtlasiQ0VDF9
PRIDEiQ0VDF9
ProteomicsDBi58825

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		37843, 137 antibodies

Genome annotation databases

EnsembliENST00000378372; ENSP00000367623; ENSG00000187522
GeneIDi51182
KEGGihsa:51182
UCSCiuc001inf.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51182
DisGeNETi51182

GeneCards: human genes, protein and diseases

More...GeneCardsi		HSPA14
HGNCiHGNC:29526, HSPA14
HPAiENSG00000187522, Low tissue specificity
MIMi610369, gene
neXtProtiNX_Q0VDF9
OpenTargetsiENSG00000187522
PharmGKBiPA134979057
VEuPathDBiHostDB:ENSG00000187522.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0101, Eukaryota
GeneTreeiENSGT00940000156380
HOGENOMiCLU_005965_0_3_1
InParanoidiQ0VDF9
OMAiEGKNSAN
OrthoDBi646813at2759
PhylomeDBiQ0VDF9
TreeFamiTF105045

Enzyme and pathway databases

PathwayCommonsiQ0VDF9
ReactomeiR-HSA-3371453, Regulation of HSF1-mediated heat shock response

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51182, 261 hits in 885 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HSPA14, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HSPA14

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51182
PharosiQ0VDF9, Tbio

Protein Ontology

More...PROi		PR:Q0VDF9
RNActiQ0VDF9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000187522, Expressed in secondary oocyte and 234 other tissues
ExpressionAtlasiQ0VDF9, baseline and differential
GenevisibleiQ0VDF9, HS

Family and domain databases

CDDicd10238, HSPA14-like_NBD, 1 hit
Gene3Di2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR043129, ATPase_NBD
IPR018181, Heat_shock_70_CS
IPR029047, HSP70_peptide-bd_sf
IPR013126, Hsp_70_fam
IPR042049, HSPA14_NBD
PANTHERiPTHR19375, PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012, HSP70, 1 hit
SUPFAMiSSF100920, SSF100920, 1 hit
SSF53067, SSF53067, 2 hits
PROSITEiView protein in PROSITE
PS01036, HSP70_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHSP7E_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0VDF9
Secondary accession number(s): A8K8F8
, B0YIY9, Q9P0X2, Q9UI07
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 5, 2006
Last modified: February 10, 2021
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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