UniProtKB - Q0VDF9 (HSP7E_HUMAN)
Protein
Heat shock 70 kDa protein 14
Gene
HSPA14
Organism
Homo sapiens (Human)
Status
Functioni
Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.1 Publication
Miscellaneous
Acts as a potent immunoadjuvant, capable to interact with antigen-presenting cells and generating efficient CD8+ T-cell responses. May be used as adjuvant to enhance effect of vaccine G1F/M2, a candidate vaccine against respiratory syncytial virus (RSV), a major respiratory pathogen in newborns (PubMed:18851947). May also be used as adjuvant to prepare antigenic fusion protein for the therapeutics of cancers (PubMed:15930317).2 Publications
GO - Molecular functioni
- ATPase activity Source: GO_Central
- ATP binding Source: GO_Central
- heat shock protein binding Source: GO_Central
- misfolded protein binding Source: GO_Central
- protein folding chaperone Source: GO_Central
- unfolded protein binding Source: GO_Central
GO - Biological processi
- 'de novo' cotranslational protein folding Source: UniProtKB
- cellular response to unfolded protein Source: GO_Central
- chaperone cofactor-dependent protein refolding Source: GO_Central
- protein refolding Source: GO_Central
- response to unfolded protein Source: GO_Central
- vesicle-mediated transport Source: GO_Central
Keywordsi
Molecular function | Chaperone |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q0VDF9 |
Reactomei | R-HSA-3371453, Regulation of HSF1-mediated heat shock response |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock 70 kDa protein 14Alternative name(s): HSP70-like protein 1 Heat shock protein HSP60 |
Gene namesi | Name:HSPA14 Synonyms:HSP60, HSP70L1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29526, HSPA14 |
MIMi | 610369, gene |
neXtProti | NX_Q0VDF9 |
VEuPathDBi | HostDB:ENSG00000187522.13 |
Subcellular locationi
Cytosol
- cytosol 1 Publication
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 51182 |
OpenTargetsi | ENSG00000187522 |
PharmGKBi | PA134979057 |
Miscellaneous databases
Pharosi | Q0VDF9, Tbio |
Genetic variation databases
BioMutai | HSPA14 |
DMDMi | 121948121 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000289946 | 1 – 509 | Heat shock 70 kDa protein 14Add BLAST | 509 |
Proteomic databases
EPDi | Q0VDF9 |
jPOSTi | Q0VDF9 |
MassIVEi | Q0VDF9 |
MaxQBi | Q0VDF9 |
PaxDbi | Q0VDF9 |
PeptideAtlasi | Q0VDF9 |
PRIDEi | Q0VDF9 |
ProteomicsDBi | 58825 |
PTM databases
iPTMneti | Q0VDF9 |
PhosphoSitePlusi | Q0VDF9 |
SwissPalmi | Q0VDF9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000187522, Expressed in secondary oocyte and 234 other tissues |
ExpressionAtlasi | Q0VDF9, baseline and differential |
Genevisiblei | Q0VDF9, HS |
Organism-specific databases
HPAi | ENSG00000187522, Low tissue specificity |
Interactioni
Subunit structurei
Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
1 PublicationGO - Molecular functioni
- heat shock protein binding Source: GO_Central
- misfolded protein binding Source: GO_Central
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 119358, 41 interactors |
DIPi | DIP-62114N |
IntActi | Q0VDF9, 24 interactors |
MINTi | Q0VDF9 |
STRINGi | 9606.ENSP00000367623 |
Miscellaneous databases
RNActi | Q0VDF9, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the heat shock protein 70 family.Curated
Phylogenomic databases
eggNOGi | KOG0101, Eukaryota |
GeneTreei | ENSGT00940000156380 |
HOGENOMi | CLU_005965_0_3_1 |
InParanoidi | Q0VDF9 |
OMAi | EGKNSAN |
OrthoDBi | 646813at2759 |
PhylomeDBi | Q0VDF9 |
TreeFami | TF105045 |
Family and domain databases
CDDi | cd10238, HSPA14-like_NBD, 1 hit |
Gene3Di | 2.60.34.10, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam IPR042049, HSPA14_NBD |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 1 hit |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS01036, HSP70_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q0VDF9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAIGVHLGC TSACVAVYKD GRAGVVANDA GDRVTPAVVA YSENEEIVGL
60 70 80 90 100
AAKQSRIRNI SNTVMKVKQI LGRSSSDPQA QKYIAESKCL VIEKNGKLRY
110 120 130 140 150
EIDTGEETKF VNPEDVARLI FSKMKETAHS VLGSDANDVV ITVPFDFGEK
160 170 180 190 200
QKNALGEAAR AAGFNVLRLI HEPSAALLAY GIGQDSPTGK SNILVFKLGG
210 220 230 240 250
TSLSLSVMEV NSGIYRVLST NTDDNIGGAH FTETLAQYLA SEFQRSFKHD
260 270 280 290 300
VRGNARAMMK LTNSAEVAKH SLSTLGSANC FLDSLYEGQD FDCNVSRARF
310 320 330 340 350
ELLCSPLFNK CIEAIRGLLD QNGFTADDIN KVVLCGGSSR IPKLQQLIKD
360 370 380 390 400
LFPAVELLNS IPPDEVIPIG AAIEAGILIG KENLLVEDSL MIECSARDIL
410 420 430 440 450
VKGVDESGAS RFTVLFPSGT PLPARRQHTL QAPGSISSVC LELYESDGKN
460 470 480 490 500
SAKEETKFAQ VVLQDLDKKE NGLRDILAVL TMKRDGSLHV TCTDQETGKC
EAISIEIAS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C2A1 | H7C2A1_HUMAN | Heat shock 70 kDa protein 14 | HSPA14 | 128 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 | V → A in BAF85012 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 15 | V → E in AAF66640 (PubMed:14592822).Curated | 1 | |
Sequence conflicti | 282 | L → P in AAF17198 (PubMed:10931946).Curated | 1 | |
Sequence conflicti | 312 | I → L in AAF17198 (PubMed:10931946).Curated | 1 | |
Sequence conflicti | 350 | D → G in BAF85012 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036347 | 85 | A → V in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs374837716Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF143723 mRNA Translation: AAF66640.1 AF112210 mRNA Translation: AAF17198.1 AK292323 mRNA Translation: BAF85012.1 EF444968 Genomic DNA Translation: ACA05969.1 EF444968 Genomic DNA Translation: ACA05970.1 AC069544 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86258.1 BC119690 mRNA Translation: AAI19691.1 |
CCDSi | CCDS7103.1 |
RefSeqi | NP_057383.2, NM_016299.3 |
Genome annotation databases
Ensembli | ENST00000378372; ENSP00000367623; ENSG00000187522 |
GeneIDi | 51182 |
KEGGi | hsa:51182 |
UCSCi | uc001inf.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF143723 mRNA Translation: AAF66640.1 AF112210 mRNA Translation: AAF17198.1 AK292323 mRNA Translation: BAF85012.1 EF444968 Genomic DNA Translation: ACA05969.1 EF444968 Genomic DNA Translation: ACA05970.1 AC069544 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86258.1 BC119690 mRNA Translation: AAI19691.1 |
CCDSi | CCDS7103.1 |
RefSeqi | NP_057383.2, NM_016299.3 |
3D structure databases
SMRi | Q0VDF9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119358, 41 interactors |
DIPi | DIP-62114N |
IntActi | Q0VDF9, 24 interactors |
MINTi | Q0VDF9 |
STRINGi | 9606.ENSP00000367623 |
PTM databases
iPTMneti | Q0VDF9 |
PhosphoSitePlusi | Q0VDF9 |
SwissPalmi | Q0VDF9 |
Genetic variation databases
BioMutai | HSPA14 |
DMDMi | 121948121 |
Proteomic databases
EPDi | Q0VDF9 |
jPOSTi | Q0VDF9 |
MassIVEi | Q0VDF9 |
MaxQBi | Q0VDF9 |
PaxDbi | Q0VDF9 |
PeptideAtlasi | Q0VDF9 |
PRIDEi | Q0VDF9 |
ProteomicsDBi | 58825 |
Protocols and materials databases
Antibodypediai | 37843, 137 antibodies |
Genome annotation databases
Ensembli | ENST00000378372; ENSP00000367623; ENSG00000187522 |
GeneIDi | 51182 |
KEGGi | hsa:51182 |
UCSCi | uc001inf.5, human |
Organism-specific databases
CTDi | 51182 |
DisGeNETi | 51182 |
GeneCardsi | HSPA14 |
HGNCi | HGNC:29526, HSPA14 |
HPAi | ENSG00000187522, Low tissue specificity |
MIMi | 610369, gene |
neXtProti | NX_Q0VDF9 |
OpenTargetsi | ENSG00000187522 |
PharmGKBi | PA134979057 |
VEuPathDBi | HostDB:ENSG00000187522.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0101, Eukaryota |
GeneTreei | ENSGT00940000156380 |
HOGENOMi | CLU_005965_0_3_1 |
InParanoidi | Q0VDF9 |
OMAi | EGKNSAN |
OrthoDBi | 646813at2759 |
PhylomeDBi | Q0VDF9 |
TreeFami | TF105045 |
Enzyme and pathway databases
PathwayCommonsi | Q0VDF9 |
Reactomei | R-HSA-3371453, Regulation of HSF1-mediated heat shock response |
Miscellaneous databases
BioGRID-ORCSi | 51182, 261 hits in 885 CRISPR screens |
ChiTaRSi | HSPA14, human |
GeneWikii | HSPA14 |
GenomeRNAii | 51182 |
Pharosi | Q0VDF9, Tbio |
PROi | PR:Q0VDF9 |
RNActi | Q0VDF9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000187522, Expressed in secondary oocyte and 234 other tissues |
ExpressionAtlasi | Q0VDF9, baseline and differential |
Genevisiblei | Q0VDF9, HS |
Family and domain databases
CDDi | cd10238, HSPA14-like_NBD, 1 hit |
Gene3Di | 2.60.34.10, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam IPR042049, HSPA14_NBD |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 1 hit |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS01036, HSP70_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HSP7E_HUMAN | |
Accessioni | Q0VDF9Primary (citable) accession number: Q0VDF9 Secondary accession number(s): A8K8F8 Q9UI07 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | September 5, 2006 | |
Last modified: | February 10, 2021 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families