UniProtKB - Q0VDD8 (DYH14_HUMAN)
Dynein axonemal heavy chain 14
DNAH14
Functioni
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 1164 – 1171 | ATPSequence analysis | 8 | |
Nucleotide bindingi | 1427 – 1434 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: InterPro
- dynein intermediate chain binding Source: GO_Central
- dynein light intermediate chain binding Source: GO_Central
- minus-end-directed microtubule motor activity Source: GO_Central
GO - Biological processi
- cilium-dependent cell motility Source: InterPro
- microtubule-based movement Source: GO_Central
Keywordsi
Molecular function | Motor protein |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q0VDD8 |
SignaLinki | Q0VDD8 |
Names & Taxonomyi
Protein namesi | Recommended name: Dynein axonemal heavy chain 14Alternative name(s): Axonemal beta dynein heavy chain 14 Ciliary dynein heavy chain 14 |
Gene namesi | Name:DNAH14 Synonyms:C1orf67 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2945, DNAH14 |
MIMi | 603341, gene |
neXtProti | NX_Q0VDD8 |
VEuPathDBi | HostDB:ENSG00000185842 |
Subcellular locationi
Cytoskeleton
- cilium axoneme Curated
Cytoskeleton
- axonemal dynein complex Source: InterPro
- dynein complex Source: GO_Central
- microtubule Source: UniProtKB-KW
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 127602 |
OpenTargetsi | ENSG00000185842 |
PharmGKBi | PA27399 |
Miscellaneous databases
Pharosi | Q0VDD8, Tdark |
Genetic variation databases
BioMutai | DNAH14 |
DMDMi | 172046085 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000286560 | 1 – 3507 | Dynein axonemal heavy chain 14Add BLAST | 3507 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 1818 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q0VDD8 |
jPOSTi | Q0VDD8 |
MassIVEi | Q0VDD8 |
MaxQBi | Q0VDD8 |
PeptideAtlasi | Q0VDD8 |
PRIDEi | Q0VDD8 |
PTM databases
GlyGeni | Q0VDD8, 1 site |
iPTMneti | Q0VDD8 |
PhosphoSitePlusi | Q0VDD8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000185842, Expressed in intestine and 133 other tissues |
ExpressionAtlasi | Q0VDD8, baseline and differential |
Genevisiblei | Q0VDD8, HS |
Organism-specific databases
HPAi | ENSG00000185842, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Consists of at least two heavy chains and a number of intermediate and light chains.
GO - Molecular functioni
- dynein intermediate chain binding Source: GO_Central
- dynein light intermediate chain binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 126070, 27 interactors |
IntActi | Q0VDD8, 11 interactors |
Miscellaneous databases
RNActi | Q0VDD8, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 91 – 126 | DisorderedSequence analysisAdd BLAST | 36 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 354 – 381 | Sequence analysisAdd BLAST | 28 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1164 – 1171 | GPAGTGKT motifBy similarity | 8 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
GeneTreei | ENSGT00940000160505 |
HOGENOMi | CLU_000038_6_0_1 |
InParanoidi | Q0VDD8 |
OMAi | MFYNDCI |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q0VDD8 |
TreeFami | TF342240 |
Family and domain databases
Gene3Di | 1.10.8.710, 1 hit 3.10.490.20, 1 hit 3.40.50.300, 6 hits |
InterProi | View protein in InterPro IPR035699, AAA_6 IPR035706, AAA_9 IPR026980, DNAH6/14 IPR043157, Dynein_AAA1S IPR041466, Dynein_AAA5_ext IPR041228, Dynein_C IPR043160, Dynein_C_barrel IPR024743, Dynein_HC_stalk IPR024317, Dynein_heavy_chain_D4_dom IPR027417, P-loop_NTPase |
PANTHERi | PTHR46454:SF6, PTHR46454:SF6, 6 hits |
Pfami | View protein in Pfam PF12774, AAA_6, 2 hits PF12780, AAA_8, 1 hit PF12781, AAA_9, 2 hits PF17852, Dynein_AAA_lid, 1 hit PF18199, Dynein_C, 1 hit PF12777, MT, 1 hit |
SUPFAMi | SSF52540, SSF52540, 4 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGRRSQWIWA MRCQMLVPVL SLHIGLARAL GCGCIASKIE CLIRCNAPFP
60 70 80 90 100
LLDAVGSVAS QELQSLTGTV GVTSGAAAYP RWNLARARAP PHLPGTQDPL
110 120 130 140 150
RRVRDPTPIV ASSPGRRRGS WSGGYGQEAS EPGVVGLCCA VLPIHPSLAL
160 170 180 190 200
AGVGGPDLRR FQEGPQRPSD HGAAEKHMET FIPIDLTTEN QEMDKEETKT
210 220 230 240 250
KPRLLRYEEK KYEDVKPLET QPAEIAEKET LEYKTVRTFS ESLKSEKTEE
260 270 280 290 300
PKDDDVIRNI IRLREKLGWQ TILPQHSLKY GSSKIAIQKI TLKKPLEDDG
310 320 330 340 350
EFVYCLPRKS PKSLYNPYDL QVVSAHTAKH CKEFWVITAS FISKLDSSRT
360 370 380 390 400
YSLDEFCEEQ LQQATQALKQ LEDIRNKAIS EMKSTFLKVA EKNEIKEYFE
410 420 430 440 450
SKLSEDDTTH FKLPKYRRLL ETFFKFVMLV DYIFQELIRQ LMNTAVTLLL
460 470 480 490 500
ELFNGSAGMP FSVEKKNENL IRTFKDNSFP TGKTTNDCEE LVDNSKLHAI
510 520 530 540 550
SVQKSEVKTD TDINEILNSV EVGKDLRKTY APIFEVNLCL RIPAESDSSE
560 570 580 590 600
NSKENFHESD QCPEECVMFE DEMSENKDNC VKKHSSEELL PKAKKSKEIS
610 620 630 640 650
YNLEDIISAT ITPLCQDPQL SIFIDLVSIM DLPNKTGSII HYKEQTRWPD
660 670 680 690 700
CHILFETDPA YQNIIVNLLT IIGNSMGLVN AYSHKFIKYC TMTEKAKIMS
710 720 730 740 750
MKISSMGELT SKEFEAILNR FRNYFRHIVN MAIEKRIGIF NVVVESSLQQ
760 770 780 790 800
LECDPTEIEE FLEHFIFLNA ISSKISKLEK EFLTMSQLYS VAKHHQIHIS
810 820 830 840 850
EEQIAIFQVL LLKFSQLKSS MKLSKINKDT AITKFRDNLE ACISGLHVDV
860 870 880 890 900
GNLKAKIRTP LLLCAGTQVS TAMEMIQTLS GEAASLTNKA KAYSHYQDCF
910 920 930 940 950
SDSQSHMHSV NVEEITQIVL SEISDIEGDL TLRKKLWEAQ EEWKRASWEW
960 970 980 990 1000
RNSSLQSIDV ESVQRNVSKL MHIISVLEKE IYSIFIIPSI DDISAQLEES
1010 1020 1030 1040 1050
QVILATIKGS PHIGPIKSQI MFYNDCVKSF VSSYSREKLE KVHAGLMCHL
1060 1070 1080 1090 1100
EEVADLVVLD TSNSRTKAIL GALLILYVHC RDIVINLLLK NIFNAEDFEW
1110 1120 1130 1140 1150
TRHLQYKWNE KQKLCYVSQG NASFTYGYEY LGCTSRLVIT PLTDRCWLTL
1160 1170 1180 1190 1200
MEALHLNLGG CPAGPAGTGK TETVKDLAKC ALFAFKCNTA LIKLPNSLIV
1210 1220 1230 1240 1250
LTCFGLEKTV LVMNTVMSFR FVLEGKEIRI NMSCAVFITM NPRYGGGVEL
1260 1270 1280 1290 1300
PDNLKSLFRP VAMMVPHYQM IAEIILFSFG FKSANSLSGK LTNLYELARK
1310 1320 1330 1340 1350
QLSQQDHYNF GLRSLKIVLI MAGTKKREFK CDTSDSLSEA DETLIVIEAI
1360 1370 1380 1390 1400
REASLPKCPP EDVPLFENII GDIFPEVTVL KVNQLALEKV IYTATQQLGL
1410 1420 1430 1440 1450
QNWSSQKEKI IQFYNQLQVC VGVMLVGPTG GGKTTVRRIL EKALTLLPIA
1460 1470 1480 1490 1500
DFLSVAERKS ASKISERKGK VDICVLNPKC VTLSELYGQL DPNTMEWTDG
1510 1520 1530 1540 1550
LLSATIRSYV YFNTPKNTKK DIDLRLKSRI SDLSNVFKLD SSDTTETDDN
1560 1570 1580 1590 1600
IFEEIEKVVK IPENHNFDWQ WIILDGPVDT FWVENLNSVL DDTRTLCLAN
1610 1620 1630 1640 1650
SERIALTNKI RVIFEVDNLS QASPATVSRC AMVYMDPVDL GWEPYVKSWL
1660 1670 1680 1690 1700
LKTSKIISQS GVDCLEFMIK NSVTDGLQFI RNRQKFQPYP MEDITVVITL
1710 1720 1730 1740 1750
CRILDAFFDF MGKNGGFEQS DDLNDTSSKE ANSQRESVTF KDIEKRDENT
1760 1770 1780 1790 1800
WYPEKNPDKL TKIIQKLFVF AFTWAFGGAL NREDEHRENI PFCPSLEPDS
1810 1820 1830 1840 1850
LAKVTYDFDK LVHELFGNSS QVGINLPTGE CSIFGYFVDI EQCEFIPWSD
1860 1870 1880 1890 1900
LVPNDQTLIQ RDNPTKKPEV RTNKKLLKNN DHKGVVVSTI NFSTNVTAAK
1910 1920 1930 1940 1950
TKEMILKKLI RRTKDTLGAP KNNRILIFID DMNMPVSDMY GAQPPLELIR
1960 1970 1980 1990 2000
QLLDLGGVYD TEKNTWKNIQ DLSIVAACVP VVNDISPRLL KHFSMLVLPH
2010 2020 2030 2040 2050
PSQDILCTIF QIGIDGCGKK TCATLACYLT DNKLYRVPIS HKCAYIEFKE
2060 2070 2080 2090 2100
VFKKVFIHAG LKGKPTVLMV PNLNIEQDSF LEDLNYIISS GRIPDLFENV
2110 2120 2130 2140 2150
ELDSIAMKIR YLTEQSGHMD NRQSLLSFFQ KRIYKNLHIF VIMSPEGPSF
2160 2170 2180 2190 2200
RQNCRVYPSM ISSCTIDWYE RWPEEALLIV ANSFLKEKVN FENRENLKEK
2210 2220 2230 2240 2250
LAPTCVQIHK SMKDLNRKYF EETGRFYYTT PNSYLQFMET FAHILRAREE
2260 2270 2280 2290 2300
EMQTKRDRFH MGLSTILEAT TLVTEMQEEL LILGPQVEQK TKETETLMEK
2310 2320 2330 2340 2350
LRKDSQVVEK VQMLVKQDEE IVAEEVRIVE DYAQKTANEL KSVLPAFDKA
2360 2370 2380 2390 2400
IVALNALDKA DVAELRVYTR PPFLVLTVMN AVCILLQKKP NWATAKLLLS
2410 2420 2430 2440 2450
ETGFLKKLIN LDKDSIPDKV FVKLKKIVTL PDFNPHKISL VSVACCSLCQ
2460 2470 2480 2490 2500
WVIALNNYHE VQKVVGPKQI QVAEAQNVLK IARQRLAEKQ RGLQLISRWH
2510 2520 2530 2540 2550
NQGLPHGQYS VENAILIKNG QQWPLLIDPH RQAHKWIRQM EGSRLQKLSI
2560 2570 2580 2590 2600
EDSNYTKKIE NAMKTGGSVL LQSCQASTWR KKLYLSTEID NPHFLPSVYN
2610 2620 2630 2640 2650
FVTMINFTVT FQGLQDQLLS TVVTHEVPHL EDQRSKLLES ISLDAITLEE
2660 2670 2680 2690 2700
LEEKTLNLLQ KALGSILDDD KIVDTLRKSK MTSNEISKRI EATKKAESEI
2710 2720 2730 2740 2750
QAIRKNYLPI ATRGALLYFL VADLTQINYM YQFSLDWFHQ VFVSSVVSKS
2760 2770 2780 2790 2800
KEQEHSFKRE KVSPKEVHEF ISISKEPNLE NEKNLLDKHI KSAIDMLTKS
2810 2820 2830 2840 2850
IFKVVSSALF NEDKLCFSFR LCTVIMQNNA NGNLIQDDIG FLPEEEWNIF
2860 2870 2880 2890 2900
LYSGILINIK SALSQSRLTS TFEIGESQHL QWLSDSRWRQ CQYVSTHLEP
2910 2920 2930 2940 2950
FSLLCKSLLS NVSQWDTFKN SKAVYSLIST PFSSENASLE ENTKPPEEKH
2960 2970 2980 2990 3000
TFCLLLRAIN HTGTDLGPVG RGQWLTSTAC DRHTDVCSFS FALNDGVPDV
3010 3020 3030 3040 3050
EHVQDIFYGH CVDKYHVKVL RPESLNNSVR KFITEKMGNK YLQRTGVNLK
3060 3070 3080 3090 3100
DAYKGSNART PLILIQTHGS ASIKDYIHII QSLPDDDLPE VLGIHPEAIR
3110 3120 3130 3140 3150
SCWETQGEKF IENLIAMQPK TTTANLMIRP EQSKDELVME ILSDLLKRLP
3160 3170 3180 3190 3200
LTVEKEEIAV GTPSTLKSMM SSSIWESLSK NLKDHDPLIH CVLLTFLKQE
3210 3220 3230 3240 3250
IKRFDKLLFV IHKSLKDLQL AIKGEIILTQ ELEEIFNSFL NMRVPTLWQK
3260 3270 3280 3290 3300
HAYRSCKPLS SWIDDLIQRL NFFNTWAKVA YTAIQRRYMR FVTVWKQSIP
3310 3320 3330 3340 3350
STSQKCKHPE DSENNFFEGF PSRYWLPAFF FPQAFLAAVL QDYGRSRGIA
3360 3370 3380 3390 3400
VDALTFTHHV ISNTTDKDEK FSVFMPKKLN IVRRAFKGSA SSHTGVYIFG
3410 3420 3430 3440 3450
LFIEGARWNR EQKILEDSLP LEMCCDFPDI YFLPTKISTK TPNASNQTDS
3460 3470 3480 3490 3500
ELYAFECPVY QTPERSRILA TTGLPTNFLT SVYLSTKKPP SHWITMRVAL
LCEKNEK
The sequence of this isoform differs from the canonical sequence as follows:
1-177: Missing.
249-249: E → EDYLRESIIQQHMVSPEPASLKEKGKSRRKKDQTHACPNVRKARPVSYDRT
344-344: K → KVINIVGSVK...NNLSAICLVK
609-609: A → DTEIETEFENKYMYYEFPEFPTNLFIDPNRLEFSVKIQNMLTNMEKCIT
744-744: V → SLDYQSECLLYIDNVIHMSHTLIQSVIEKKNKNLLEVV
979-979: K → KGLPKSDMVT...TPLPLILHHT
1017-1017: K → KDLVNEWDQN...YIYNIILLFQ
1180-1219: CALFAFKCNT...VLVMNTVMSF → SLGKHCVVFN...IKAAKDNYSA
1332-1336: Missing.
1823-1823: G → GWKHWGQSQGRRRKGNC
1861-1861: R → RGTSLLTNLQ...ETHKTATGSS
2011-2011: Q → QAHLGIYFSI...LSRELENCFQ
2495-2495: L → LVEEHLLFLQ...LIKVMAQKYE
2573-2582: SCQASTWRKK → NLLETLAPGLKAILKKDIYQKKGHYFIRVGDAEFEYNSNFR
2949-3016: KHTFCLLLRA...FYGHCVDKYH → TELLNENKETCNPINFPWEKLTSFQRLIL
3069-3069: G → GIDLTNILLR...VLKDDFSFSR
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A804HLD3 | A0A804HLD3_HUMAN | Dynein axonemal heavy chain 14 | DNAH14 | 4,617 | Annotation score: | ||
H7BXS7 | H7BXS7_HUMAN | Dynein axonemal heavy chain 14 | DNAH14 | 1,481 | Annotation score: | ||
A0A1W2PR53 | A0A1W2PR53_HUMAN | Dynein axonemal heavy chain 14 | DNAH14 | 1,477 | Annotation score: | ||
H9KV43 | H9KV43_HUMAN | Dynein axonemal heavy chain 14 | DNAH14 | 204 | Annotation score: | ||
H7C3Z3 | H7C3Z3_HUMAN | Dynein axonemal heavy chain 14 | DNAH14 | 219 | Annotation score: | ||
H0YBI3 | H0YBI3_HUMAN | Dynein axonemal heavy chain 14 | DNAH14 | 130 | Annotation score: | ||
H7C164 | H7C164_HUMAN | Dynein axonemal heavy chain 14 | DNAH14 | 299 | Annotation score: | ||
M9MMK7 | M9MMK7_HUMAN | Dynein axonemal heavy chain 14 | DNAH14 hCG_22803 | 430 | Annotation score: | ||
H7C374 | H7C374_HUMAN | Dynein axonemal heavy chain 14 | DNAH14 | 126 | Annotation score: | ||
H0YBB1 | H0YBB1_HUMAN | Dynein axonemal heavy chain 14 | DNAH14 | 68 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 424 | F → L in AAI19718 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032116 | 220 | T → S1 PublicationCorresponds to variant dbSNP:rs41267347Ensembl. | 1 | |
Natural variantiVAR_032117 | 274 | P → L1 PublicationCorresponds to variant dbSNP:rs41267349Ensembl. | 1 | |
Natural variantiVAR_057764 | 2671 | K → E. Corresponds to variant dbSNP:rs6667999Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031314 | 1 – 177 | Missing in isoform 2, isoform 3 and isoform 4. 1 PublicationAdd BLAST | 177 | |
Alternative sequenceiVSP_031315 | 249 | E → EDYLRESIIQQHMVSPEPAS LKEKGKSRRKKDQTHACPNV RKARPVSYDRT in isoform 2, isoform 3 and isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_031316 | 344 | K → KVINIVGSVKEVELIPTLEW LSERRHYYLLRQFKIFSDFR MNKAFVTWKLNVKRIKTEKS RSFLYHHLFLADDLFQTCLV YIRGLCEDAINLKNYNDHEN NLSAICLVK in isoform 2 and isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_038241 | 345 – 355 | LDSSRTYSLDE → RYLVICGAVYI in isoform 3. CuratedAdd BLAST | 11 | |
Alternative sequenceiVSP_038242 | 356 – 3507 | Missing in isoform 3. CuratedAdd BLAST | 3152 | |
Alternative sequenceiVSP_031317 | 473 – 3507 | Missing in isoform 2. 1 PublicationAdd BLAST | 3035 | |
Alternative sequenceiVSP_038243 | 609 | A → DTEIETEFENKYMYYEFPEF PTNLFIDPNRLEFSVKIQNM LTNMEKCIT in isoform 4. Curated | 1 | |
Alternative sequenceiVSP_038244 | 744 | V → SLDYQSECLLYIDNVIHMSH TLIQSVIEKKNKNLLEVV in isoform 4. Curated | 1 | |
Alternative sequenceiVSP_038245 | 979 | K → KGLPKSDMVTHLKQVVTEFK QELPIIIALGNPCLKPRHWE ALQEIIGKSVPLDKNCKVEN LLALKMFQYENEINDMSTSA TNEAALEKMLFKIIDFWNTT PLPLILHHT in isoform 4. Curated | 1 | |
Alternative sequenceiVSP_038246 | 1017 | K → KDLVNEWDQNLTLFSYTLEE WMNCQRNWLYLEPVFHSSEI RRQLPAETELFSQVISMWKK IMSKIQNKQNALQITTSAGV LEILQNCNIHLEHIKKSLED YLEVKRLIFPRFYFLSNAEL LDILADSRNPESVQPHLVKC FENIKQLLIWKQDIGPPAVK MLISAEGEGLVLPKKIRVRS AVEQWLVNVEKSMFDVLKKE RYIYNIILLFQ in isoform 4. Curated | 1 | |
Alternative sequenceiVSP_038247 | 1180 – 1219 | CALFA…TVMSF → SLGKHCVVFNCFEDLDYKIV RKFFFGLVQSGAWSCFDEFN LIDLEVLSVIASQILTIKAA KDNYSA in isoform 4. CuratedAdd BLAST | 40 | |
Alternative sequenceiVSP_038248 | 1332 – 1336 | Missing in isoform 4. Curated | 5 | |
Alternative sequenceiVSP_038249 | 1823 | G → GWKHWGQSQGRRRKGNC in isoform 4. Curated | 1 | |
Alternative sequenceiVSP_038250 | 1861 | R → RGTSLLTNLQRSGGNFLKIT ECGECINYTATRDTTCLSFL MSLLLKNSCPVLLTGESGVG KTAAINQMLEKLEGPGAFDI KHGSILGDTLLYSEIKKSSS LKQNITILIPETHKTATGSS in isoform 4. Curated | 1 | |
Alternative sequenceiVSP_038251 | 2011 | Q → QAHLGIYFSINNFTPEVQKS KDQIISCSLAIYHQVRQNML PTPTKCHYMFNLRDMFKLLL GLLQADRTVVNSKEMAALLF VHEATRVFHDRLIDFTDKSL FYRLLSRELENCFQ in isoform 4. Curated | 1 | |
Alternative sequenceiVSP_038252 | 2495 | L → LVEEHLLFLQAAYKDTVAEK QLLANRKTMASRRFQCASVL LTVLEDEKTRWQETINQIDN KLEGILGDILLSAACIVYSG ILTPEFRQLIVNKWETFCIE NGISLSSKFSLIKVMAQKYE in isoform 4. Curated | 1 | |
Alternative sequenceiVSP_038253 | 2573 – 2582 | SCQASTWRKK → NLLETLAPGLKAILKKDIYQ KKGHYFIRVGDAEFEYNSNF R in isoform 4. Curated | 10 | |
Alternative sequenceiVSP_038254 | 2949 – 3016 | KHTFC…VDKYH → TELLNENKETCNPINFPWEK LTSFQRLIL in isoform 4. CuratedAdd BLAST | 68 | |
Alternative sequenceiVSP_038255 | 3069 | G → GIDLTNILLRFAQELKGTTH HVTIISLGRDQAAKAEDLIL KALTKTQQWVFLQNCHLATS FMPRLCTIVESFNSPNVTID PEFRLWLSSKSYSSFPIPVL KKGLKIAVESPQGLKSNLLQ TFGCTGSGEVTEEIFENPDC GQWWKKLLFSLCFFNAVINE RKNYGILGWNIAYKFNSSDL GVAIKVLENSLRGQPSISWQ ALRYLIGEVIYGGRVIDNWD KRCLKTLLYKFCNPEVLKDD FSFSR in isoform 4. Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC093560 Genomic DNA No translation available. AL590547 Genomic DNA No translation available. AL596134 Genomic DNA No translation available. AL645769 Genomic DNA No translation available. AC092811 Genomic DNA No translation available. AL162738 Genomic DNA No translation available. AL357912 Genomic DNA No translation available. CH471098 Genomic DNA Translation: EAW69735.1 Sequence problems. BC119716 mRNA Translation: AAI19717.1 Different initiation. BC119717 mRNA Translation: AAI19718.1 Different initiation. |
CCDSi | CCDS41472.1 [Q0VDD8-3] CCDS44322.1 [Q0VDD8-2] |
RefSeqi | NP_001138626.1, NM_001145154.1 [Q0VDD8-2] NP_001364.1, NM_001373.1 NP_659426.2, NM_144989.2 [Q0VDD8-3] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC093560 Genomic DNA No translation available. AL590547 Genomic DNA No translation available. AL596134 Genomic DNA No translation available. AL645769 Genomic DNA No translation available. AC092811 Genomic DNA No translation available. AL162738 Genomic DNA No translation available. AL357912 Genomic DNA No translation available. CH471098 Genomic DNA Translation: EAW69735.1 Sequence problems. BC119716 mRNA Translation: AAI19717.1 Different initiation. BC119717 mRNA Translation: AAI19718.1 Different initiation. |
CCDSi | CCDS41472.1 [Q0VDD8-3] CCDS44322.1 [Q0VDD8-2] |
RefSeqi | NP_001138626.1, NM_001145154.1 [Q0VDD8-2] NP_001364.1, NM_001373.1 NP_659426.2, NM_144989.2 [Q0VDD8-3] |
3D structure databases
SMRi | Q0VDD8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126070, 27 interactors |
IntActi | Q0VDD8, 11 interactors |
PTM databases
GlyGeni | Q0VDD8, 1 site |
iPTMneti | Q0VDD8 |
PhosphoSitePlusi | Q0VDD8 |
Genetic variation databases
BioMutai | DNAH14 |
DMDMi | 172046085 |
Proteomic databases
EPDi | Q0VDD8 |
jPOSTi | Q0VDD8 |
MassIVEi | Q0VDD8 |
MaxQBi | Q0VDD8 |
PeptideAtlasi | Q0VDD8 |
PRIDEi | Q0VDD8 |
Protocols and materials databases
Antibodypediai | 34641, 78 antibodies from 14 providers |
DNASUi | 127602 |
Genome annotation databases
Organism-specific databases
CTDi | 127602 |
DisGeNETi | 127602 |
GeneCardsi | DNAH14 |
HGNCi | HGNC:2945, DNAH14 |
HPAi | ENSG00000185842, Tissue enhanced (testis) |
MIMi | 603341, gene |
neXtProti | NX_Q0VDD8 |
OpenTargetsi | ENSG00000185842 |
PharmGKBi | PA27399 |
VEuPathDBi | HostDB:ENSG00000185842 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000160505 |
HOGENOMi | CLU_000038_6_0_1 |
InParanoidi | Q0VDD8 |
OMAi | MFYNDCI |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q0VDD8 |
TreeFami | TF342240 |
Enzyme and pathway databases
PathwayCommonsi | Q0VDD8 |
SignaLinki | Q0VDD8 |
Miscellaneous databases
BioGRID-ORCSi | 127602, 11 hits in 1079 CRISPR screens |
ChiTaRSi | DNAH14, human |
GenomeRNAii | 127602 |
Pharosi | Q0VDD8, Tdark |
PROi | PR:Q0VDD8 |
RNActi | Q0VDD8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000185842, Expressed in intestine and 133 other tissues |
ExpressionAtlasi | Q0VDD8, baseline and differential |
Genevisiblei | Q0VDD8, HS |
Family and domain databases
Gene3Di | 1.10.8.710, 1 hit 3.10.490.20, 1 hit 3.40.50.300, 6 hits |
InterProi | View protein in InterPro IPR035699, AAA_6 IPR035706, AAA_9 IPR026980, DNAH6/14 IPR043157, Dynein_AAA1S IPR041466, Dynein_AAA5_ext IPR041228, Dynein_C IPR043160, Dynein_C_barrel IPR024743, Dynein_HC_stalk IPR024317, Dynein_heavy_chain_D4_dom IPR027417, P-loop_NTPase |
PANTHERi | PTHR46454:SF6, PTHR46454:SF6, 6 hits |
Pfami | View protein in Pfam PF12774, AAA_6, 2 hits PF12780, AAA_8, 1 hit PF12781, AAA_9, 2 hits PF17852, Dynein_AAA_lid, 1 hit PF18199, Dynein_C, 1 hit PF12777, MT, 1 hit |
SUPFAMi | SSF52540, SSF52540, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | DYH14_HUMAN | |
Accessioni | Q0VDD8Primary (citable) accession number: Q0VDD8 Secondary accession number(s): A6NG62 Q5VU34 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | February 26, 2008 | |
Last modified: | May 25, 2022 | |
This is version 126 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families