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UniProtKB - Q0VDC6 (Q0VDC6_HUMAN)

Entry version 100 (07 Apr 2021)
Sequence version 1 (05 Sep 2006)
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Protein

Peptidylprolyl isomerase

Gene

FKBP1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, RotamasePROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptidylprolyl isomerasePROSITE-ProRule annotation (EC:5.2.1.8PROSITE-ProRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FKBP1AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28153

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q0VDC6

PeptideAtlas

More...PeptideAtlasi		Q0VDC6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q0VDC6, HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q0VDC6
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-10226858,EBI-11096309
ADAL - isoform 2 [Q6DHV7-2]3EBI-10226858,EBI-18899653
AK8 [Q96MA6]3EBI-10226858,EBI-8466265
ANXA4 [Q6LES2]3EBI-10226858,EBI-10250835
ARL6IP4 - isoform 4 [Q66PJ3-4]3EBI-10226858,EBI-5280499
ASB9 [Q96DX5]3EBI-10226858,EBI-745641
ASH2L [Q9UBL3]3EBI-10226858,EBI-540797
ASIC4 - isoform 3 [Q96FT7-4]3EBI-10226858,EBI-9089489
BAHD1 [Q8TBE0]3EBI-10226858,EBI-742750
BEX5 [Q5H9J7]3EBI-10226858,EBI-10243741
CBWD1 [Q9BRT8]3EBI-10226858,EBI-1054417
CCDC26 [Q8TAB7]3EBI-10226858,EBI-10271580
CD209 - isoform 10 [Q9NNX6-10]3EBI-10226858,EBI-12300031
CDKN1A [P38936]3EBI-10226858,EBI-375077
CEP170B - isoform 3 [Q9Y4F5-3]3EBI-10226858,EBI-12950757
CEP76 [Q8TAP6]3EBI-10226858,EBI-742887
CHMP7 [Q8WUX9]3EBI-10226858,EBI-749253
CITED1 [Q99966]3EBI-10226858,EBI-2624951
COMMD10 [Q9Y6G5]3EBI-10226858,EBI-1550310
DNAJA3 - isoform 3 [Q96EY1-3]3EBI-10226858,EBI-11526226
DOM3Z [A0A024RCP2]3EBI-10226858,EBI-25847826
DPF1 - isoform 2 [Q92782-2]3EBI-10226858,EBI-23669343
FGF21 [Q9NSA1]3EBI-10226858,EBI-3909329
FOSL1 [P15407]3EBI-10226858,EBI-744510
GABPB1 - isoform 2 [Q06547-2]3EBI-10226858,EBI-618189
GABPB1 - isoform 3 [Q06547-3]3EBI-10226858,EBI-9088619
GTF2A1 [P52655]3EBI-10226858,EBI-389518
HAGHL [Q6PII5]3EBI-10226858,EBI-6255752
INCA1 [Q0VD86]3EBI-10226858,EBI-6509505
KCTD17 [Q8N5Z5]3EBI-10226858,EBI-743960
KLC3 [Q6P597]3EBI-10226858,EBI-1643885
LAMTOR5 [A0A0C4DGV4]3EBI-10226858,EBI-10173304
LARP4B [Q92615]3EBI-10226858,EBI-1052558
MAP3K5 [Q99683]3EBI-10226858,EBI-476263
METTL15 - isoform 4 [A6NJ78-4]3EBI-10226858,EBI-10174029
MID1 [O15344]6EBI-10226858,EBI-2340316
MIP [P30301]3EBI-10226858,EBI-8449636
NEUROD1 [Q13562]3EBI-10226858,EBI-3908303
NR2C2 [Q6PHZ7]3EBI-10226858,EBI-2802743
OTUD7B - isoform 2 [Q6GQQ9-2]3EBI-10226858,EBI-25830200
PELI3 - isoform 4 [Q8N2H9-4]3EBI-10226858,EBI-25852006
PER1 [O15534]3EBI-10226858,EBI-2557276
PLEKHG4 - isoform 2 [Q58EX7-2]3EBI-10226858,EBI-21503705
PLEKHS1 - isoform 1 [Q5SXH7-1]3EBI-10226858,EBI-26412802
POLA2 [Q14181]3EBI-10226858,EBI-712752
POLR3F [Q9H1D9]3EBI-10226858,EBI-710067
PRPS1 [P60891]3EBI-10226858,EBI-749195
PRR3 [P79522]3EBI-10226858,EBI-2803328
PSMF1 [Q92530]3EBI-10226858,EBI-945916
RANGRF - isoform 3 [Q9HD47-3]3EBI-10226858,EBI-9089733
SERTAD4 [Q9NUC0]3EBI-10226858,EBI-1773811
SF3B4 [Q15427]3EBI-10226858,EBI-348469
SLC7A8 [Q9UHI5]3EBI-10226858,EBI-13292283
SNCA [P37840]3EBI-10226858,EBI-985879
SOCS6 [O14544]3EBI-10226858,EBI-3929549
SPATA12 [Q7Z6I5]3EBI-10226858,EBI-10696971
SPATS1 [Q496A3]3EBI-10226858,EBI-3923692
SYNCRIP - isoform 4 [O60506-4]3EBI-10226858,EBI-11123832
TAF8 - isoform 2 [Q7Z7C8-2]3EBI-10226858,EBI-9089028
TMEM61 [Q8N0U2]3EBI-10226858,EBI-25830583
TMTC1 - isoform 4 [Q8IUR5-4]3EBI-10226858,EBI-9089156
TSPAN2 [O60636]3EBI-10226858,EBI-3914288
UBE2A [P49459]3EBI-10226858,EBI-2339348
WBP1L [Q9NX94]3EBI-10226858,EBI-10316321
ZKSCAN3 [Q9BRR0]3EBI-10226858,EBI-1965777
ZNF124 [Q15973]3EBI-10226858,EBI-2555767
ZNF296 [Q8WUU4]3EBI-10226858,EBI-8834821
ZNF341 - isoform 2 [Q9BYN7-2]3EBI-10226858,EBI-16435478
ZNF829 - isoform 3 [Q3KNS6-3]3EBI-10226858,EBI-18036029

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q0VDC6, 68 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q0VDC6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 145PPIase FKBP-typeInterPro annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 35DisorderedSequence analysisAdd BLAST35

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001179, PPIase_FKBP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00254, FKBP_C, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50059, FKBP_PPIASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q0VDC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRQRAEGLG RAVEPPPGRC WSTPPVAPPA RSASAAAMGV QVETISPGDG 
        60         70         80         90        100
RTFPKRGQTC VVHYTGMLED GKKFDSSRDR NKPFKFMLGK QEVIRGWEEG 
       110        120        130        140 
VAQMSVGQRA KLTISPDYAY GATGHPGIIP PHATLVFDVE LLKLE
Length:145
Mass (Da):15,689
Last modified:September 5, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDFB0CDCB1F74A847
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC119732 mRNA Translation: AAI19733.1

NCBI Reference Sequences

More...RefSeqi		NP_000792.1, NM_000801.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2280

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2280

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119732 mRNA Translation: AAI19733.1
RefSeqiNP_000792.1, NM_000801.4

3D structure databases

SMRiQ0VDC6
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ0VDC6, 68 interactors

Proteomic databases

MaxQBiQ0VDC6
PeptideAtlasiQ0VDC6

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		2280

Genome annotation databases

GeneIDi2280
KEGGihsa:2280

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2280
PharmGKBiPA28153

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2280, 235 hits in 927 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FKBP1A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2280

Gene expression databases

GenevisibleiQ0VDC6, HS

Family and domain databases

InterProiView protein in InterPro
IPR001179, PPIase_FKBP_dom
PfamiView protein in Pfam
PF00254, FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059, FKBP_PPIASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ0VDC6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0VDC6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: April 7, 2021
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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