Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q0VD86 (INCA1_HUMAN)

Protein

Protein INCA1

Gene

INCA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187). Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cyclin binding Source: MGI
  • cyclin-dependent protein serine/threonine kinase inhibitor activity Source: MGI
  • protein-containing complex binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtein kinase inhibitor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein INCA1
Alternative name(s):
Inhibitor of CDK interacting with cyclin A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INCA1
ORF Names:HSD45
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000196388.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:32224 INCA1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617374 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q0VD86

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi23S → A: Loss of phosphorylation site. 1 Publication1
Mutagenesisi182T → A: Reduced phosphorylation. Phosphorylation is almost abolished; when associated with A-191. 1 Publication1
Mutagenesisi191S → A: Strongly reduced phosphorylation. Phosphorylation is almost abolished; when associated with A-182. 1 Publication1
Mutagenesisi194S → A: Reduced phosphorylation. 1 Publication1

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000196388

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165431930

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		INCA1

Domain mapping of disease mutations (DMDM)

More...DMDMi		121940471

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003315131 – 236Protein INCA1Add BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei23Phosphoserine1 Publication1
Modified residuei182Phosphothreonine1 Publication1
Modified residuei191Phosphoserine1 Publication1
Modified residuei194Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated when part of a complex with CCNA1 and CDK2. Strongly phosphorylated by CDK2 on its C-terminal region spanning amino acid 149-221. Less intensively phosphorylated by CDK2 on its first 75 amino acid residues.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q0VD86

PeptideAtlas

More...PeptideAtlasi		Q0VD86

PRoteomics IDEntifications database

More...PRIDEi		Q0VD86

ProteomicsDB human proteome resource

More...ProteomicsDBi		58815
58816 [Q0VD86-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q0VD86

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q0VD86

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in testis, and at lower levels in ovary. Detected at very low levels in testis tumors (PubMed:15159402). Down-regulated in bone marrow cells in acute myeloid and lymphoid leukemia patients as compared with normal bone marrow cells (PubMed:21540187).2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By serum starvation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196388 Expressed in 88 organ(s), highest expression level in right testis

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA044359
HPA052401

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CCNA1 (PubMed:21540187, PubMed:15159402). Interacts with CCNA2, CCNB1 and CCNE1 (PubMed:21540187). Found in a complex with CCNA1 and CDK2 (PubMed:15159402). Interacts with ZNF16; the interaction inhibits INCA1 activity and induces the cell cycle process (PubMed:21874239). Interacts with SPACA9 (PubMed:18756329). Interacts with the CCNA1/CDK2 complex (PubMed:21540187). Interacts with ING5, DAZAP2, RNF26, USP15, SPOUT1, DPH7, TRIM26 and RAB5C (PubMed:21750715).5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		132642, 33 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q0VD86

Protein interaction database and analysis system

More...IntActi		Q0VD86, 233 interactors

Molecular INTeraction database

More...MINTi		Q0VD86

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000380041

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q0VD86

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni75 – 99Interaction with CCNA1 and CCNA1/CDK2 complex; essential for CDK2 inhibitory activity1 PublicationAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi90 – 95Nuclear localization signalSequence analysis6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the INCA family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IVSD Eukaryota
ENOG4111D98 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000242

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000113068

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG095410

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q0VD86

Identification of Orthologs from Complete Genome Data

More...OMAi		WSPLGQE

Database of Orthologous Groups

More...OrthoDBi		1275701at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q0VD86

TreeFam database of animal gene trees

More...TreeFami		TF343431

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026238 INCA1

The PANTHER Classification System

More...PANTHERi		PTHR37341 PTHR37341, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15142 INCA1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR02102 PROTEININCA1

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q0VD86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQVQDDGVNL IPFAKCSRVV SRSPPPRLPS QSLRPMPQRY GDVFWKNLNQ 
        60         70         80         90        100
RPTPTWLEEQ HIPPMLRATG CSQLGLYPPE QLPPPEMLWR RKKRRPCLEG 
       110        120        130        140        150
MQQQGLGGVP ARVRAVTYHL EDLRRRQSII NELKKAQWGS SGAASEPVVL 
       160        170        180        190        200
GEEGCGFPST NEYPDLEEER ATYPQEEDRF LTPGRAQLLW SPWSPLDQEE 
       210        220        230 
ACASRQLHSL ASFSTVTARR NPLHNPWGME LAASEE
Length:236
Mass (Da):26,817
Last modified:September 5, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9808D24144AB07D
GO
Isoform 2 (identifier: Q0VD86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-81: Missing.

Show »
Length:221
Mass (Da):25,216
Checksum:iA1070CBDD2CA4650
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti153E → D in AAT09152 (PubMed:15159402).Curated1
Sequence conflicti153E → D in AAT09153 (PubMed:15159402).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03323567 – 81Missing in isoform 2. 2 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY601906 mRNA Translation: AAT09152.1
AY601907 mRNA Translation: AAT09153.1
AY604176 mRNA Translation: AAT36739.1
BC119781 mRNA Translation: AAI19782.1
BC122873 mRNA Translation: AAI22874.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11064.1 [Q0VD86-2]
CCDS54074.1 [Q0VD86-1]

NCBI Reference Sequences

More...RefSeqi		NP_001161457.1, NM_001167985.1 [Q0VD86-2]
NP_001161458.1, NM_001167986.1 [Q0VD86-1]
NP_001161459.1, NM_001167987.1 [Q0VD86-1]
NP_998891.2, NM_213726.2 [Q0VD86-2]
XP_005256684.1, XM_005256627.3 [Q0VD86-1]
XP_005256685.1, XM_005256628.4 [Q0VD86-1]
XP_005256686.1, XM_005256629.1 [Q0VD86-2]
XP_006721580.1, XM_006721517.1 [Q0VD86-1]
XP_006721581.1, XM_006721518.2 [Q0VD86-2]
XP_006721582.1, XM_006721519.3 [Q0VD86-2]
XP_011522134.1, XM_011523832.2 [Q0VD86-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.658926

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355025; ENSP00000347129; ENSG00000196388 [Q0VD86-2]
ENST00000574617; ENSP00000458316; ENSG00000196388 [Q0VD86-1]
ENST00000575780; ENSP00000461844; ENSG00000196388 [Q0VD86-2]
ENST00000576820; ENSP00000460673; ENSG00000196388 [Q0VD86-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		388324

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:388324

UCSC genome browser

More...UCSCi		uc002gal.3 human [Q0VD86-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY601906 mRNA Translation: AAT09152.1
AY601907 mRNA Translation: AAT09153.1
AY604176 mRNA Translation: AAT36739.1
BC119781 mRNA Translation: AAI19782.1
BC122873 mRNA Translation: AAI22874.1
CCDSiCCDS11064.1 [Q0VD86-2]
CCDS54074.1 [Q0VD86-1]
RefSeqiNP_001161457.1, NM_001167985.1 [Q0VD86-2]
NP_001161458.1, NM_001167986.1 [Q0VD86-1]
NP_001161459.1, NM_001167987.1 [Q0VD86-1]
NP_998891.2, NM_213726.2 [Q0VD86-2]
XP_005256684.1, XM_005256627.3 [Q0VD86-1]
XP_005256685.1, XM_005256628.4 [Q0VD86-1]
XP_005256686.1, XM_005256629.1 [Q0VD86-2]
XP_006721580.1, XM_006721517.1 [Q0VD86-1]
XP_006721581.1, XM_006721518.2 [Q0VD86-2]
XP_006721582.1, XM_006721519.3 [Q0VD86-2]
XP_011522134.1, XM_011523832.2 [Q0VD86-1]
UniGeneiHs.658926

3D structure databases

ProteinModelPortaliQ0VD86
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132642, 33 interactors
ELMiQ0VD86
IntActiQ0VD86, 233 interactors
MINTiQ0VD86
STRINGi9606.ENSP00000380041

PTM databases

iPTMnetiQ0VD86
PhosphoSitePlusiQ0VD86

Polymorphism and mutation databases

BioMutaiINCA1
DMDMi121940471

Proteomic databases

PaxDbiQ0VD86
PeptideAtlasiQ0VD86
PRIDEiQ0VD86
ProteomicsDBi58815
58816 [Q0VD86-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355025; ENSP00000347129; ENSG00000196388 [Q0VD86-2]
ENST00000574617; ENSP00000458316; ENSG00000196388 [Q0VD86-1]
ENST00000575780; ENSP00000461844; ENSG00000196388 [Q0VD86-2]
ENST00000576820; ENSP00000460673; ENSG00000196388 [Q0VD86-1]
GeneIDi388324
KEGGihsa:388324
UCSCiuc002gal.3 human [Q0VD86-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		388324
EuPathDBiHostDB:ENSG00000196388.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		INCA1

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0027201
HGNCiHGNC:32224 INCA1
HPAiHPA044359
HPA052401
MIMi617374 gene
neXtProtiNX_Q0VD86
OpenTargetsiENSG00000196388
PharmGKBiPA165431930

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IVSD Eukaryota
ENOG4111D98 LUCA
GeneTreeiENSGT00390000000242
HOGENOMiHOG000113068
HOVERGENiHBG095410
InParanoidiQ0VD86
OMAiWSPLGQE
OrthoDBi1275701at2759
PhylomeDBiQ0VD86
TreeFamiTF343431

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		INCA1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		388324

Protein Ontology

More...PROi		PR:Q0VD86

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196388 Expressed in 88 organ(s), highest expression level in right testis

Family and domain databases

InterProiView protein in InterPro
IPR026238 INCA1
PANTHERiPTHR37341 PTHR37341, 1 hit
PfamiView protein in Pfam
PF15142 INCA1, 1 hit
PRINTSiPR02102 PROTEININCA1

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINCA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0VD86
Secondary accession number(s): Q6J273, Q6PKN9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 5, 2006
Last modified: January 16, 2019
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again