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UniProtKB - Q0VD86 (INCA1_HUMAN)

Entry version 107 (12 Aug 2020)
Sequence version 1 (05 Sep 2006)
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Protein

Protein INCA1

Gene

INCA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187). Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtein kinase inhibitor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q0VD86

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein INCA1
Alternative name(s):
Inhibitor of CDK interacting with cyclin A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INCA1
ORF Names:HSD45
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000196388.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:32224, INCA1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617374, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q0VD86

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi23S → A: Loss of phosphorylation site. 1 Publication1
Mutagenesisi182T → A: Reduced phosphorylation. Phosphorylation is almost abolished; when associated with A-191. 1 Publication1
Mutagenesisi191S → A: Strongly reduced phosphorylation. Phosphorylation is almost abolished; when associated with A-182. 1 Publication1
Mutagenesisi194S → A: Reduced phosphorylation. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		388324

Open Targets

More...OpenTargetsi		ENSG00000196388

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165431930

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q0VD86, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		INCA1

Domain mapping of disease mutations (DMDM)

More...DMDMi		121940471

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003315131 – 236Protein INCA1Add BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei23Phosphoserine1 Publication1
Modified residuei182Phosphothreonine1 Publication1
Modified residuei191Phosphoserine1 Publication1
Modified residuei194Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated when part of a complex with CCNA1 and CDK2. Strongly phosphorylated by CDK2 on its C-terminal region spanning amino acid 149-221. Less intensively phosphorylated by CDK2 on its first 75 amino acid residues.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q0VD86

PeptideAtlas

More...PeptideAtlasi		Q0VD86

PRoteomics IDEntifications database

More...PRIDEi		Q0VD86

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58815 [Q0VD86-1]
58816 [Q0VD86-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q0VD86

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q0VD86

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in testis, and at lower levels in ovary. Detected at very low levels in testis tumors (PubMed:15159402). Down-regulated in bone marrow cells in acute myeloid and lymphoid leukemia patients as compared with normal bone marrow cells (PubMed:21540187).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By serum starvation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196388, Expressed in right testis and 114 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196388, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CCNA1 (PubMed:21540187, PubMed:15159402).

Interacts with CCNA2, CCNB1 and CCNE1 (PubMed:21540187).

Found in a complex with CCNA1 and CDK2 (PubMed:15159402).

Interacts with ZNF16; the interaction inhibits INCA1 activity and induces the cell cycle process (PubMed:21874239).

Interacts with SPACA9 (PubMed:18756329).

Interacts with the CCNA1/CDK2 complex (PubMed:21540187).

Interacts with ING5, DAZAP2, RNF26, USP15, SPOUT1, DPH7, TRIM26 and RAB5C (PubMed:21750715).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q0VD86
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-6509505,EBI-11096309
ACY3 [Q96HD9]5EBI-6509505,EBI-3916242
AKAP8L [Q9ULX6]3EBI-6509505,EBI-357530
ANKRD28 [O15084]3EBI-6509505,EBI-359567
ARMC7 [Q9H6L4]3EBI-6509505,EBI-742909
ASPSCR1 [Q9BZE9]3EBI-6509505,EBI-1993677
ATG5 [Q9H1Y0]3EBI-6509505,EBI-1047414
ATP6V0D2 [Q8N8Y2]3EBI-6509505,EBI-3923949
ATPAF2 [Q8N5M1]3EBI-6509505,EBI-1166928
BAG3 [O95817]3EBI-6509505,EBI-747185
BANF2 - isoform 2 [Q9H503-2]3EBI-6509505,EBI-11977289
BOLA3 [Q53S33]3EBI-6509505,EBI-12086950
BPIFA1 [Q9NP55]3EBI-6509505,EBI-953896
C10orf55 [Q5SWW7]3EBI-6509505,EBI-12809220
C19orf54 - isoform 3 [Q5BKX5-3]3EBI-6509505,EBI-11976299
C1orf50 [Q9BV19]3EBI-6509505,EBI-2874661
C22orf39 [Q6P5X5]3EBI-6509505,EBI-7317823
CABP5 [Q9NP86]10EBI-6509505,EBI-10311131
CCBE1 - isoform 3 [Q6UXH8-3]3EBI-6509505,EBI-12013534
CCDC57 - isoform 2 [Q2TAC2-2]3EBI-6509505,EBI-10961624
CCDC78 - isoform 4 [A2IDD5-4]3EBI-6509505,EBI-18205352
CDA [P32320]3EBI-6509505,EBI-9250559
CDC23 [Q9UJX2]3EBI-6509505,EBI-396137
CDK18 [Q07002]3EBI-6509505,EBI-746238
CDK4 [P11802]3EBI-6509505,EBI-295644
CDKN1A [P38936]3EBI-6509505,EBI-375077
CDKN2B [P42772]3EBI-6509505,EBI-711280
CDKN2D [P55273]9EBI-6509505,EBI-745859
CEP72 [Q9P209]3EBI-6509505,EBI-739498
CHCHD2 [Q9Y6H1]3EBI-6509505,EBI-2321769
CHCHD5 [Q9BSY4]3EBI-6509505,EBI-11521409
CHRD [Q9H2X0]3EBI-6509505,EBI-947551
CINP [Q9BW66]3EBI-6509505,EBI-739784
CKS1B [P61024]3EBI-6509505,EBI-456371
CLIC3 [O95833]3EBI-6509505,EBI-10192241
CLK3 [P49761]3EBI-6509505,EBI-745579
COL8A1 [P27658]9EBI-6509505,EBI-747133
CPSF1 [Q10570]3EBI-6509505,EBI-347859
CSDC2 [Q9Y534]3EBI-6509505,EBI-1763657
CSTF2 [P33240]3EBI-6509505,EBI-711360
CTNNBIP1 [Q9NSA3]3EBI-6509505,EBI-747082
CTTNBP2 [Q8WZ74]3EBI-6509505,EBI-1774260
CYSRT1 [A8MQ03]3EBI-6509505,EBI-3867333
DAZAP2 [Q15038]2EBI-6509505,EBI-724310
DEF6 [Q9H4E7]3EBI-6509505,EBI-745369
DMRT3 [Q9NQL9]6EBI-6509505,EBI-9679045
DMRTB1 [Q96MA1]3EBI-6509505,EBI-954466
DOK4 [Q8TEW6]3EBI-6509505,EBI-6918542
DPH7 [Q9BTV6]2EBI-6509505,EBI-11059920
DUSP13 [Q9UII6]3EBI-6509505,EBI-749800
EFEMP2 [O95967]3EBI-6509505,EBI-743414
EMD [P50402]3EBI-6509505,EBI-489887
EPHB6 - isoform 2 [O15197-2]8EBI-6509505,EBI-10182490
EXOSC8 [Q96B26]3EBI-6509505,EBI-371922
FAAP20 - isoform 4 [Q6NZ36-4]3EBI-6509505,EBI-12013806
FAIM - isoform 2 [Q9NVQ4-2]3EBI-6509505,EBI-12039347
FEM1A [Q9BSK4]3EBI-6509505,EBI-2515349
FGF16 [O43320]3EBI-6509505,EBI-11479104
FHL2 [Q14192]5EBI-6509505,EBI-701903
FRS3 [O43559]3EBI-6509505,EBI-725515
GEM [P55040]3EBI-6509505,EBI-744104
GEMIN2 [O14893]3EBI-6509505,EBI-443648
GRB2 [P62993]4EBI-6509505,EBI-401755
GRXCR1 [A8MXD5]3EBI-6509505,EBI-5235612
GSTO2 [Q9H4Y5]3EBI-6509505,EBI-10194609
GTF2H5 [Q6ZYL4]3EBI-6509505,EBI-6380438
GTPBP3 [Q969Y2]3EBI-6509505,EBI-740290
GYS1 [P13807]3EBI-6509505,EBI-740553
HAUS1 [Q96CS2]3EBI-6509505,EBI-2514791
HCK - isoform 2 [P08631-2]3EBI-6509505,EBI-9834454
HDAC4 - isoform 2 [P56524-2]3EBI-6509505,EBI-11953488
HEMK1 [Q9Y5R4]5EBI-6509505,EBI-10329202
HENMT1 [Q5T8I9]3EBI-6509505,EBI-9675710
HNRNPF [P52597]3EBI-6509505,EBI-352986
HOMER3 [Q9NSC5]3EBI-6509505,EBI-748420
HOXA1 [P49639]3EBI-6509505,EBI-740785
HR [O43593]3EBI-6509505,EBI-2880706
HSD17B14 [Q9BPX1]3EBI-6509505,EBI-742664
IL36RN [Q9UBH0]3EBI-6509505,EBI-465156
ILF2 [Q12905]3EBI-6509505,EBI-357925
itself3EBI-6509505,EBI-6509505
ING5 [Q8WYH8]4EBI-6509505,EBI-488533
KCTD7 - isoform 2 [Q96MP8-2]3EBI-6509505,EBI-11954971
KCTD9 [Q7L273]3EBI-6509505,EBI-4397613
KIAA1217 - isoform 6 [Q5T5P2-6]3EBI-6509505,EBI-10188326
KIR2DL4 [Q99706]3EBI-6509505,EBI-10294579
KLHL26 [Q53HC5]3EBI-6509505,EBI-724915
KLHL42 [Q9P2K6]3EBI-6509505,EBI-739890
KRT33B [Q14525]3EBI-6509505,EBI-1049638
KRT5 [P13647]3EBI-6509505,EBI-702187
KRT75 [O95678]3EBI-6509505,EBI-2949715
KRTAP15-1 [Q3LI76]3EBI-6509505,EBI-11992140
KRTAP19-1 [Q8IUB9]3EBI-6509505,EBI-12811111
KRTAP19-5 [Q3LI72]5EBI-6509505,EBI-1048945
KRTAP19-6 [Q3LI70]3EBI-6509505,EBI-12805508
KRTAP5-6 [Q6L8G9]3EBI-6509505,EBI-10250562
KRTAP6-2 [Q3LI66]5EBI-6509505,EBI-11962084
KRTAP9-3 [Q9BYQ3]3EBI-6509505,EBI-1043191
LENG8 [Q96PV6]3EBI-6509505,EBI-739546
LGALS3 [P17931]3EBI-6509505,EBI-1170392
LHX3 - isoform B [Q9UBR4-2]5EBI-6509505,EBI-12039345
LMNTD2 [Q8IXW0]3EBI-6509505,EBI-12028858
LMO2 - isoform 3 [P25791-3]3EBI-6509505,EBI-11959475
LMO3 - isoform 4 [Q8TAP4-4]5EBI-6509505,EBI-11742507
LSM3 [P62310]3EBI-6509505,EBI-348239
LYPLA2 [O95372]3EBI-6509505,EBI-715999
MAD2L2 [Q9UI95]3EBI-6509505,EBI-77889
MAGED4 [Q96JG8]3EBI-6509505,EBI-721864
MAGOHB [Q96A72]3EBI-6509505,EBI-746778
MALSU1 [Q96EH3]3EBI-6509505,EBI-2339737
MARF1 [Q9Y4F3]3EBI-6509505,EBI-5235902
MARK1 [Q9P0L2]3EBI-6509505,EBI-968587
MATN3 [O15232]3EBI-6509505,EBI-6262458
MENT [Q9BUN1]3EBI-6509505,EBI-12022316
METAP1 [P53582]3EBI-6509505,EBI-1051435
MMTAG2 [Q9BU76]3EBI-6509505,EBI-742459
MPP1 [Q00013]3EBI-6509505,EBI-711788
MSRB1 [Q9NZV6]3EBI-6509505,EBI-12330065
MTMR9 [Q96QG7]3EBI-6509505,EBI-744593
NATD1 [Q8N6N6]3EBI-6509505,EBI-8656665
NCK2 [O43639]3EBI-6509505,EBI-713635
NDUFAF3 [Q9BU61]3EBI-6509505,EBI-2114801
NEDD9 - isoform 2 [Q14511-2]3EBI-6509505,EBI-11746523
NEIL2 [Q969S2]3EBI-6509505,EBI-10281234
NEK6 [Q9HC98]4EBI-6509505,EBI-740364
NEK6 - isoform 4 [Q9HC98-4]3EBI-6509505,EBI-11750983
NFKBID [Q8NI38]3EBI-6509505,EBI-10271199
NHSL2 [Q5HYW2]3EBI-6509505,EBI-2859639
NME7 [Q9Y5B8]5EBI-6509505,EBI-744782
NMRK1 [Q9NWW6]3EBI-6509505,EBI-10315485
NPAS2 [Q99743]3EBI-6509505,EBI-3932727
NUBP2 [Q9Y5Y2]3EBI-6509505,EBI-1048886
NUDT16L1 [Q9BRJ7]3EBI-6509505,EBI-2949792
NUDT22 [Q9BRQ3]3EBI-6509505,EBI-10297093
OR6B1 [O95007]3EBI-6509505,EBI-12176191
OSGIN1 [Q9UJX0]6EBI-6509505,EBI-9057006
PADI3 [Q9ULW8]3EBI-6509505,EBI-10488185
PATE1 [Q8WXA2]3EBI-6509505,EBI-10277790
PCSK5 - isoform PC6A [Q92824-2]3EBI-6509505,EBI-11956269
PCYT2 [Q99447]3EBI-6509505,EBI-750317
PDP1 [Q9P0J1]3EBI-6509505,EBI-2861634
PEF1 [Q9UBV8]3EBI-6509505,EBI-724639
PFDN5 [Q99471]3EBI-6509505,EBI-357275
PHF1 [O43189]3EBI-6509505,EBI-530034
PLA2G10 [O15496]3EBI-6509505,EBI-726466
PLSCR3 [Q9NRY6]3EBI-6509505,EBI-750734
POLR1C [O15160]3EBI-6509505,EBI-1055079
POLR3C [Q9BUI4]3EBI-6509505,EBI-5452779
POP5 [Q969H6]3EBI-6509505,EBI-366525
POU4F2 [Q12837]3EBI-6509505,EBI-17236143
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-6509505,EBI-12000762
PRPH [P41219]3EBI-6509505,EBI-752074
PSMB2 [P49721]3EBI-6509505,EBI-359335
PSMB8 - isoform 2 [P28062-2]3EBI-6509505,EBI-372312
PTGER3 - isoform 12 [P43115-12]3EBI-6509505,EBI-10234038
R3HDM2 [Q9Y2K5]3EBI-6509505,EBI-948428
RAB5C [P51148]2EBI-6509505,EBI-1054923
RACK1 [P63244]2EBI-6509505,EBI-296739
RALB [P11234]3EBI-6509505,EBI-752162
RAMAC [Q9BTL3]6EBI-6509505,EBI-744023
RBPMS [Q93062]3EBI-6509505,EBI-740322
RBPMS - isoform C [Q93062-3]3EBI-6509505,EBI-740343
RECK [Q6P9E2]3EBI-6509505,EBI-10253121
RFC3 [P40938]3EBI-6509505,EBI-1055010
RIPPLY3 [P57055]3EBI-6509505,EBI-12092053
RNF26 [Q9BY78]2EBI-6509505,EBI-2129375
SAP18 [O00422]3EBI-6509505,EBI-1044156
SCNM1 [Q9BWG6]4EBI-6509505,EBI-748391
SEC14L4 [Q9UDX3]3EBI-6509505,EBI-10320311
SHFL - isoform 4 [Q9NUL5-4]3EBI-6509505,EBI-11955083
SLC22A18AS - isoform 2 [Q8N1D0-2]3EBI-6509505,EBI-12829638
SMG9 [Q9H0W8]3EBI-6509505,EBI-2872322
SMUG1 - isoform 2 [Q53HV7-2]3EBI-6509505,EBI-12275818
SNRPB - isoform SM-B [P14678-2]3EBI-6509505,EBI-372475
SPAG8 - isoform 2 [Q99932-2]3EBI-6509505,EBI-11959123
SPG21 [Q9NZD8]6EBI-6509505,EBI-742688
SPOUT1 [Q5T280]2EBI-6509505,EBI-2880213
SPRY1 [O43609]3EBI-6509505,EBI-3866665
STAMBPL1 [Q96FJ0]3EBI-6509505,EBI-745021
STK16 [O75716]6EBI-6509505,EBI-749295
STT3B [Q8TCJ2]3EBI-6509505,EBI-2256290
SUOX [P51687]5EBI-6509505,EBI-3921347
TBC1D7 [Q9P0N9]3EBI-6509505,EBI-3258000
TCL1A [P56279]3EBI-6509505,EBI-749995
TEAD4 [Q15561]3EBI-6509505,EBI-747736
TEKT4 [Q8WW24]3EBI-6509505,EBI-750487
TEX12 [Q9BXU0]3EBI-6509505,EBI-12090309
TFAP2A - isoform 2 [P05549-5]3EBI-6509505,EBI-12194905
TFAP2D [Q7Z6R9]5EBI-6509505,EBI-11952651
TFAP4 [Q01664]3EBI-6509505,EBI-2514218
TFG [Q92734]3EBI-6509505,EBI-357061
THAP6 [Q8TBB0]3EBI-6509505,EBI-3925505
THRSP [Q92748]3EBI-6509505,EBI-1749955
TIAL1 - isoform 2 [Q01085-2]3EBI-6509505,EBI-11064654
TPRX1 - isoform 2 [Q8N7U7-2]3EBI-6509505,EBI-14115717
TRAPPC2 - isoform 3 [P0DI81-3]3EBI-6509505,EBI-11961968
TRAPPC6A - isoform 2 [O75865-2]3EBI-6509505,EBI-8451480
TRIB3 [Q96RU7]3EBI-6509505,EBI-492476
TRIM26 [Q12899]2EBI-6509505,EBI-2341136
TRIM68 [Q6AZZ1]3EBI-6509505,EBI-2130449
TRIP13 [Q15645]3EBI-6509505,EBI-358993
TRIP6 [Q15654]3EBI-6509505,EBI-742327
TSEN15 [Q8WW01]3EBI-6509505,EBI-372432
TSG101 [Q99816]3EBI-6509505,EBI-346882
TSSK3 [Q96PN8]3EBI-6509505,EBI-3918381
TSTD2 [Q5T7W7]3EBI-6509505,EBI-8994397
TXNDC17 [Q9BRA2]3EBI-6509505,EBI-1055906
UBASH3B [Q8TF42]3EBI-6509505,EBI-1380492
UBE2D4 [Q9Y2X8]3EBI-6509505,EBI-745527
UBE2Z [Q9H832]3EBI-6509505,EBI-720977
UBTD2 [Q8WUN7]3EBI-6509505,EBI-12867288
UBXN2B [Q14CS0]6EBI-6509505,EBI-1993619
UFM1 [P61960]3EBI-6509505,EBI-1045061
UFSP1 [Q6NVU6]3EBI-6509505,EBI-12068150
USP15 [Q9Y4E8]2EBI-6509505,EBI-1043104
VEZF1 [Q14119]3EBI-6509505,EBI-11980193
VGLL3 - isoform 2 [A8MV65-2]3EBI-6509505,EBI-11957216
VPS26C [O14972]3EBI-6509505,EBI-7207091
VPS28 [Q548N1]3EBI-6509505,EBI-10243107
WDYHV1 [Q96HA8]5EBI-6509505,EBI-741158
WWOX - isoform 5 [Q9NZC7-5]3EBI-6509505,EBI-12040603
YIPF3 [Q9GZM5]3EBI-6509505,EBI-743787
YOD1 [Q5VVQ6]3EBI-6509505,EBI-2510804
ZDHHC24 [Q6UX98]3EBI-6509505,EBI-10254561
ZFAND3 [Q9H8U3]3EBI-6509505,EBI-725171
ZMYND12 [Q9H0C1]3EBI-6509505,EBI-12030590
ZMYND19 [Q96E35]3EBI-6509505,EBI-746595
ZNF16 [P17020]2EBI-6509505,EBI-3921553
ZNF32 [P17041]3EBI-6509505,EBI-1965483
ZNF446 - isoform 2 [Q9NWS9-2]3EBI-6509505,EBI-740232
ZNF747 [Q9BV97]3EBI-6509505,EBI-4395497
ZNF765 - isoform 2 [Q7L2R6-2]3EBI-6509505,EBI-12834294
ZNRD2 [O60232]3EBI-6509505,EBI-741415
G4XUV33EBI-6509505,EBI-10177989

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		132642, 40 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q0VD86

Protein interaction database and analysis system

More...IntActi		Q0VD86, 236 interactors

Molecular INTeraction database

More...MINTi		Q0VD86

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000458316

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q0VD86, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni75 – 99Interaction with CCNA1 and CCNA1/CDK2 complex; essential for CDK2 inhibitory activity1 PublicationAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi90 – 95Nuclear localization signalSequence analysis6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the INCA family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SX61, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000242

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_103802_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q0VD86

Identification of Orthologs from Complete Genome Data

More...OMAi		WMEEQYI

Database of Orthologous Groups

More...OrthoDBi		1275701at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q0VD86

TreeFam database of animal gene trees

More...TreeFami		TF343431

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026238, INCA1

The PANTHER Classification System

More...PANTHERi		PTHR37341, PTHR37341, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15142, INCA1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR02102, PROTEININCA1

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q0VD86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQVQDDGVNL IPFAKCSRVV SRSPPPRLPS QSLRPMPQRY GDVFWKNLNQ 
        60         70         80         90        100
RPTPTWLEEQ HIPPMLRATG CSQLGLYPPE QLPPPEMLWR RKKRRPCLEG 
       110        120        130        140        150
MQQQGLGGVP ARVRAVTYHL EDLRRRQSII NELKKAQWGS SGAASEPVVL 
       160        170        180        190        200
GEEGCGFPST NEYPDLEEER ATYPQEEDRF LTPGRAQLLW SPWSPLDQEE 
       210        220        230 
ACASRQLHSL ASFSTVTARR NPLHNPWGME LAASEE
Length:236
Mass (Da):26,817
Last modified:September 5, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9808D24144AB07D
GO
Isoform 2 (identifier: Q0VD86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-81: Missing.

Show »
Length:221
Mass (Da):25,216
Checksum:iA1070CBDD2CA4650
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti153E → D in AAT09152 (PubMed:15159402).Curated1
Sequence conflicti153E → D in AAT09153 (PubMed:15159402).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03323567 – 81Missing in isoform 2. 2 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY601906 mRNA Translation: AAT09152.1
AY601907 mRNA Translation: AAT09153.1
AY604176 mRNA Translation: AAT36739.1
BC119781 mRNA Translation: AAI19782.1
BC122873 mRNA Translation: AAI22874.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11064.1 [Q0VD86-2]
CCDS54074.1 [Q0VD86-1]

NCBI Reference Sequences

More...RefSeqi		NP_001161457.1, NM_001167985.1 [Q0VD86-2]
NP_001161458.1, NM_001167986.1 [Q0VD86-1]
NP_001161459.1, NM_001167987.1 [Q0VD86-1]
NP_998891.2, NM_213726.2 [Q0VD86-2]
XP_005256684.1, XM_005256627.3 [Q0VD86-1]
XP_005256685.1, XM_005256628.4 [Q0VD86-1]
XP_005256686.1, XM_005256629.1 [Q0VD86-2]
XP_006721580.1, XM_006721517.1 [Q0VD86-1]
XP_006721581.1, XM_006721518.2 [Q0VD86-2]
XP_006721582.1, XM_006721519.3 [Q0VD86-2]
XP_011522134.1, XM_011523832.2 [Q0VD86-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355025; ENSP00000347129; ENSG00000196388 [Q0VD86-2]
ENST00000574617; ENSP00000458316; ENSG00000196388 [Q0VD86-1]
ENST00000575780; ENSP00000461844; ENSG00000196388 [Q0VD86-2]
ENST00000576820; ENSP00000460673; ENSG00000196388 [Q0VD86-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		388324

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:388324

UCSC genome browser

More...UCSCi		uc002gal.3, human [Q0VD86-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY601906 mRNA Translation: AAT09152.1
AY601907 mRNA Translation: AAT09153.1
AY604176 mRNA Translation: AAT36739.1
BC119781 mRNA Translation: AAI19782.1
BC122873 mRNA Translation: AAI22874.1
CCDSiCCDS11064.1 [Q0VD86-2]
CCDS54074.1 [Q0VD86-1]
RefSeqiNP_001161457.1, NM_001167985.1 [Q0VD86-2]
NP_001161458.1, NM_001167986.1 [Q0VD86-1]
NP_001161459.1, NM_001167987.1 [Q0VD86-1]
NP_998891.2, NM_213726.2 [Q0VD86-2]
XP_005256684.1, XM_005256627.3 [Q0VD86-1]
XP_005256685.1, XM_005256628.4 [Q0VD86-1]
XP_005256686.1, XM_005256629.1 [Q0VD86-2]
XP_006721580.1, XM_006721517.1 [Q0VD86-1]
XP_006721581.1, XM_006721518.2 [Q0VD86-2]
XP_006721582.1, XM_006721519.3 [Q0VD86-2]
XP_011522134.1, XM_011523832.2 [Q0VD86-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi132642, 40 interactors
ELMiQ0VD86
IntActiQ0VD86, 236 interactors
MINTiQ0VD86
STRINGi9606.ENSP00000458316

PTM databases

iPTMnetiQ0VD86
PhosphoSitePlusiQ0VD86

Polymorphism and mutation databases

BioMutaiINCA1
DMDMi121940471

Proteomic databases

PaxDbiQ0VD86
PeptideAtlasiQ0VD86
PRIDEiQ0VD86
ProteomicsDBi58815 [Q0VD86-1]
58816 [Q0VD86-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		51738, 127 antibodies

Genome annotation databases

EnsembliENST00000355025; ENSP00000347129; ENSG00000196388 [Q0VD86-2]
ENST00000574617; ENSP00000458316; ENSG00000196388 [Q0VD86-1]
ENST00000575780; ENSP00000461844; ENSG00000196388 [Q0VD86-2]
ENST00000576820; ENSP00000460673; ENSG00000196388 [Q0VD86-1]
GeneIDi388324
KEGGihsa:388324
UCSCiuc002gal.3, human [Q0VD86-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		388324
DisGeNETi388324
EuPathDBiHostDB:ENSG00000196388.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		INCA1
HGNCiHGNC:32224, INCA1
HPAiENSG00000196388, Tissue enriched (testis)
MIMi617374, gene
neXtProtiNX_Q0VD86
OpenTargetsiENSG00000196388
PharmGKBiPA165431930

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SX61, Eukaryota
GeneTreeiENSGT00390000000242
HOGENOMiCLU_103802_0_0_1
InParanoidiQ0VD86
OMAiWMEEQYI
OrthoDBi1275701at2759
PhylomeDBiQ0VD86
TreeFamiTF343431

Enzyme and pathway databases

PathwayCommonsiQ0VD86

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		388324, 4 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		INCA1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		388324
PharosiQ0VD86, Tbio

Protein Ontology

More...PROi		PR:Q0VD86
RNActiQ0VD86, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196388, Expressed in right testis and 114 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR026238, INCA1
PANTHERiPTHR37341, PTHR37341, 1 hit
PfamiView protein in Pfam
PF15142, INCA1, 1 hit
PRINTSiPR02102, PROTEININCA1

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINCA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0VD86
Secondary accession number(s): Q6J273, Q6PKN9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 5, 2006
Last modified: August 12, 2020
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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