UniProtKB - Q0VD86 (INCA1_HUMAN)
Protein INCA1
INCA1
Functioni
Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187).
Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity).
Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity).
By similarity1 PublicationGO - Molecular functioni
- cyclin binding Source: MGI
- cyclin-dependent protein serine/threonine kinase inhibitor activity Source: MGI
- identical protein binding Source: IntAct
- protein-containing complex binding Source: UniProtKB
GO - Biological processi
- negative regulation of cell population proliferation Source: GO_Central
- negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
- positive regulation of apoptotic signaling pathway Source: Ensembl
Keywordsi
Molecular function | Protein kinase inhibitor |
Enzyme and pathway databases
PathwayCommonsi | Q0VD86 |
SignaLinki | Q0VD86 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein INCA1Alternative name(s): Inhibitor of CDK interacting with cyclin A1 |
Gene namesi | Name:INCA1 ORF Names:HSD45 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:32224, INCA1 |
MIMi | 617374, gene |
neXtProti | NX_Q0VD86 |
VEuPathDBi | HostDB:ENSG00000196388 |
Subcellular locationi
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 23 | S → A: Loss of phosphorylation site. 1 Publication | 1 | |
Mutagenesisi | 182 | T → A: Reduced phosphorylation. Phosphorylation is almost abolished; when associated with A-191. 1 Publication | 1 | |
Mutagenesisi | 191 | S → A: Strongly reduced phosphorylation. Phosphorylation is almost abolished; when associated with A-182. 1 Publication | 1 | |
Mutagenesisi | 194 | S → A: Reduced phosphorylation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 388324 |
MalaCardsi | INCA1 |
OpenTargetsi | ENSG00000196388 |
PharmGKBi | PA165431930 |
Miscellaneous databases
Pharosi | Q0VD86, Tbio |
Genetic variation databases
BioMutai | INCA1 |
DMDMi | 121940471 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000331513 | 1 – 236 | Protein INCA1Add BLAST | 236 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 23 | Phosphoserine1 Publication | 1 | |
Modified residuei | 182 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 191 | Phosphoserine1 Publication | 1 | |
Modified residuei | 194 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q0VD86 |
PeptideAtlasi | Q0VD86 |
PRIDEi | Q0VD86 |
PTM databases
iPTMneti | Q0VD86 |
PhosphoSitePlusi | Q0VD86 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000196388, Expressed in right testis and 115 other tissues |
Organism-specific databases
HPAi | ENSG00000196388, Tissue enriched (testis) |
Interactioni
Subunit structurei
Interacts with CCNA1 (PubMed:21540187, PubMed:15159402).
Interacts with CCNA2, CCNB1 and CCNE1 (PubMed:21540187).
Found in a complex with CCNA1 and CDK2 (PubMed:15159402).
Interacts with ZNF16; the interaction inhibits INCA1 activity and induces the cell cycle process (PubMed:21874239).
Interacts with SPACA9 (PubMed:18756329).
Interacts with the CCNA1/CDK2 complex (PubMed:21540187).
Interacts with ING5, DAZAP2, RNF26, USP15, SPOUT1, DPH7, TRIM26 and RAB5C (PubMed:21750715).
5 PublicationsBinary interactionsi
Q0VD86
GO - Molecular functioni
- cyclin binding Source: MGI
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 132642, 239 interactors |
ELMi | Q0VD86 |
IntActi | Q0VD86, 252 interactors |
MINTi | Q0VD86 |
STRINGi | 9606.ENSP00000458316 |
Miscellaneous databases
RNActi | Q0VD86, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 75 – 99 | Interaction with CCNA1 and CCNA1/CDK2 complex; essential for CDK2 inhibitory activity1 PublicationAdd BLAST | 25 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 90 – 95 | Nuclear localization signalSequence analysis | 6 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502SX61, Eukaryota |
GeneTreei | ENSGT00390000000242 |
HOGENOMi | CLU_103802_0_0_1 |
InParanoidi | Q0VD86 |
OMAi | WMEEQYI |
OrthoDBi | 1275701at2759 |
PhylomeDBi | Q0VD86 |
TreeFami | TF343431 |
Family and domain databases
InterProi | View protein in InterPro IPR026238, INCA1 |
PANTHERi | PTHR37341, PTHR37341, 1 hit |
Pfami | View protein in Pfam PF15142, INCA1, 1 hit |
PRINTSi | PR02102, PROTEININCA1 |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQVQDDGVNL IPFAKCSRVV SRSPPPRLPS QSLRPMPQRY GDVFWKNLNQ
60 70 80 90 100
RPTPTWLEEQ HIPPMLRATG CSQLGLYPPE QLPPPEMLWR RKKRRPCLEG
110 120 130 140 150
MQQQGLGGVP ARVRAVTYHL EDLRRRQSII NELKKAQWGS SGAASEPVVL
160 170 180 190 200
GEEGCGFPST NEYPDLEEER ATYPQEEDRF LTPGRAQLLW SPWSPLDQEE
210 220 230
ACASRQLHSL ASFSTVTARR NPLHNPWGME LAASEE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 153 | E → D in AAT09152 (PubMed:15159402).Curated | 1 | |
Sequence conflicti | 153 | E → D in AAT09153 (PubMed:15159402).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033235 | 67 – 81 | Missing in isoform 2. 2 PublicationsAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY601906 mRNA Translation: AAT09152.1 AY601907 mRNA Translation: AAT09153.1 AY604176 mRNA Translation: AAT36739.1 BC119781 mRNA Translation: AAI19782.1 BC122873 mRNA Translation: AAI22874.1 |
CCDSi | CCDS11064.1 [Q0VD86-2] CCDS54074.1 [Q0VD86-1] |
RefSeqi | NP_001161457.1, NM_001167985.1 [Q0VD86-2] NP_001161458.1, NM_001167986.1 [Q0VD86-1] NP_001161459.1, NM_001167987.1 [Q0VD86-1] NP_998891.2, NM_213726.2 [Q0VD86-2] XP_005256684.1, XM_005256627.3 [Q0VD86-1] XP_005256685.1, XM_005256628.4 [Q0VD86-1] XP_005256686.1, XM_005256629.1 [Q0VD86-2] XP_006721580.1, XM_006721517.1 [Q0VD86-1] XP_006721581.1, XM_006721518.2 [Q0VD86-2] XP_006721582.1, XM_006721519.3 [Q0VD86-2] XP_011522134.1, XM_011523832.2 [Q0VD86-1] |
Genome annotation databases
Ensembli | ENST00000355025; ENSP00000347129; ENSG00000196388 [Q0VD86-2] ENST00000574617; ENSP00000458316; ENSG00000196388 ENST00000575780; ENSP00000461844; ENSG00000196388 [Q0VD86-2] ENST00000576820; ENSP00000460673; ENSG00000196388 |
GeneIDi | 388324 |
KEGGi | hsa:388324 |
UCSCi | uc002gal.3, human [Q0VD86-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY601906 mRNA Translation: AAT09152.1 AY601907 mRNA Translation: AAT09153.1 AY604176 mRNA Translation: AAT36739.1 BC119781 mRNA Translation: AAI19782.1 BC122873 mRNA Translation: AAI22874.1 |
CCDSi | CCDS11064.1 [Q0VD86-2] CCDS54074.1 [Q0VD86-1] |
RefSeqi | NP_001161457.1, NM_001167985.1 [Q0VD86-2] NP_001161458.1, NM_001167986.1 [Q0VD86-1] NP_001161459.1, NM_001167987.1 [Q0VD86-1] NP_998891.2, NM_213726.2 [Q0VD86-2] XP_005256684.1, XM_005256627.3 [Q0VD86-1] XP_005256685.1, XM_005256628.4 [Q0VD86-1] XP_005256686.1, XM_005256629.1 [Q0VD86-2] XP_006721580.1, XM_006721517.1 [Q0VD86-1] XP_006721581.1, XM_006721518.2 [Q0VD86-2] XP_006721582.1, XM_006721519.3 [Q0VD86-2] XP_011522134.1, XM_011523832.2 [Q0VD86-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 132642, 239 interactors |
ELMi | Q0VD86 |
IntActi | Q0VD86, 252 interactors |
MINTi | Q0VD86 |
STRINGi | 9606.ENSP00000458316 |
PTM databases
iPTMneti | Q0VD86 |
PhosphoSitePlusi | Q0VD86 |
Genetic variation databases
BioMutai | INCA1 |
DMDMi | 121940471 |
Proteomic databases
PaxDbi | Q0VD86 |
PeptideAtlasi | Q0VD86 |
PRIDEi | Q0VD86 |
Protocols and materials databases
Antibodypediai | 51738, 135 antibodies from 20 providers |
DNASUi | 388324 |
Genome annotation databases
Ensembli | ENST00000355025; ENSP00000347129; ENSG00000196388 [Q0VD86-2] ENST00000574617; ENSP00000458316; ENSG00000196388 ENST00000575780; ENSP00000461844; ENSG00000196388 [Q0VD86-2] ENST00000576820; ENSP00000460673; ENSG00000196388 |
GeneIDi | 388324 |
KEGGi | hsa:388324 |
UCSCi | uc002gal.3, human [Q0VD86-1] |
Organism-specific databases
CTDi | 388324 |
DisGeNETi | 388324 |
GeneCardsi | INCA1 |
HGNCi | HGNC:32224, INCA1 |
HPAi | ENSG00000196388, Tissue enriched (testis) |
MalaCardsi | INCA1 |
MIMi | 617374, gene |
neXtProti | NX_Q0VD86 |
OpenTargetsi | ENSG00000196388 |
PharmGKBi | PA165431930 |
VEuPathDBi | HostDB:ENSG00000196388 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SX61, Eukaryota |
GeneTreei | ENSGT00390000000242 |
HOGENOMi | CLU_103802_0_0_1 |
InParanoidi | Q0VD86 |
OMAi | WMEEQYI |
OrthoDBi | 1275701at2759 |
PhylomeDBi | Q0VD86 |
TreeFami | TF343431 |
Enzyme and pathway databases
PathwayCommonsi | Q0VD86 |
SignaLinki | Q0VD86 |
Miscellaneous databases
BioGRID-ORCSi | 388324, 7 hits in 1040 CRISPR screens |
ChiTaRSi | INCA1, human |
GenomeRNAii | 388324 |
Pharosi | Q0VD86, Tbio |
PROi | PR:Q0VD86 |
RNActi | Q0VD86, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196388, Expressed in right testis and 115 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR026238, INCA1 |
PANTHERi | PTHR37341, PTHR37341, 1 hit |
Pfami | View protein in Pfam PF15142, INCA1, 1 hit |
PRINTSi | PR02102, PROTEININCA1 |
MobiDBi | Search... |
Entry informationi
Entry namei | INCA1_HUMAN | |
Accessioni | Q0VD86Primary (citable) accession number: Q0VD86 Secondary accession number(s): Q6J273, Q6PKN9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | September 5, 2006 | |
Last modified: | February 23, 2022 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families