UniProtKB - Q0VD84 (Q0VD84_MOUSE)
Protein
Submitted name:
Latent-transforming growth factor beta-binding protein 2
Gene
Ltbp2
Organism
Mus musculus (Mouse)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- calcium ion binding Source: InterPro
GO - Biological processi
- supramolecular fiber organization Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: Latent-transforming growth factor beta-binding protein 2ImportedSubmitted name: Ltbp2 proteinImported |
Gene namesi | Name:Ltbp2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99502, Ltbp2 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix ARBA annotation
Keywords - Cellular componenti
Extracellular matrixARBA annotation, SecretedPTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 205 ↔ 215 | PROSITE-ProRule annotation | ||
Disulfide bondi | 223 ↔ 232 | PROSITE-ProRule annotation | ||
Disulfide bondi | 405 ↔ 415 | PROSITE-ProRule annotation | ||
Disulfide bondi | 423 ↔ 432 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1497 ↔ 1507 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000002020, Expressed in fibroblast and 154 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 201 – 233 | EGF-likeInterPro annotationAdd BLAST | 33 | |
Domaini | 401 – 433 | EGF-likeInterPro annotationAdd BLAST | 33 | |
Domaini | 556 – 599 | TBInterPro annotationAdd BLAST | 44 | |
Domaini | 626 – 666 | EGF-likeInterPro annotationAdd BLAST | 41 | |
Domaini | 676 – 728 | TBInterPro annotationAdd BLAST | 53 | |
Domaini | 852 – 894 | EGF-likeInterPro annotationAdd BLAST | 43 | |
Domaini | 895 – 934 | EGF-likeInterPro annotationAdd BLAST | 40 | |
Domaini | 975 – 1015 | EGF-likeInterPro annotationAdd BLAST | 41 | |
Domaini | 1100 – 1140 | EGF-likeInterPro annotationAdd BLAST | 41 | |
Domaini | 1141 – 1182 | EGF-likeInterPro annotationAdd BLAST | 42 | |
Domaini | 1183 – 1223 | EGF-likeInterPro annotationAdd BLAST | 41 | |
Domaini | 1268 – 1309 | EGF-likeInterPro annotationAdd BLAST | 42 | |
Domaini | 1376 – 1428 | TBInterPro annotationAdd BLAST | 53 | |
Domaini | 1450 – 1492 | EGF-likeInterPro annotationAdd BLAST | 43 | |
Domaini | 1493 – 1532 | EGF-likeInterPro annotationAdd BLAST | 40 | |
Domaini | 1549 – 1601 | TBInterPro annotationAdd BLAST | 53 | |
Domaini | 1698 – 1734 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 1739 – 1783 | EGF-likeInterPro annotationAdd BLAST | 45 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 100 – 172 | DisorderedSequence analysisAdd BLAST | 73 | |
Regioni | 240 – 325 | DisorderedSequence analysisAdd BLAST | 86 | |
Regioni | 509 – 544 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 747 – 778 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 804 – 835 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 1643 – 1677 | DisorderedSequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 133 – 148 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 276 – 290 | Pro-richSequence analysisAdd BLAST | 15 |
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotationARBA annotation, SignalARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000160884 |
OrthoDBi | 1174178at2759 |
Family and domain databases
Gene3Di | 3.90.290.10, 4 hits |
InterProi | View protein in InterPro IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR017878, TB_dom IPR036773, TB_dom_sf |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF07645, EGF_CA, 15 hits PF12661, hEGF, 1 hit PF00683, TB, 4 hits |
SMARTi | View protein in SMART SM00181, EGF, 19 hits SM00179, EGF_CA, 17 hits |
SUPFAMi | SSF57184, SSF57184, 5 hits SSF57581, SSF57581, 4 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 10 hits PS00022, EGF_1, 2 hits PS01186, EGF_2, 10 hits PS50026, EGF_3, 14 hits PS01187, EGF_CA, 7 hits PS51364, TB, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
Q0VD84-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESTSPRGLR CPQLCSHSGA MRAPTTARCS GCIRRVRWRG FLPLVLAVLM
60 70 80 90 100
GTSHAQRDSI GRYEPASRDA NRLWHPVGSH PAAAAAKVYS LFREPDAPVP
110 120 130 140 150
GLSPSEWNQP AQGNPGRLAE AEARRPPRTQ QLRRVQPPVQ TRRSHPRGQQ
160 170 180 190 200
QIAARAAPSV ARLETPQRPA AARRGRLTGR NVCGGQCCPG WTTSNSTNHC
210 220 230 240 250
IKPVCQPPCQ NRGSCSRPQV CICRSGFRGA RCEEVIPEEE FDPQNARPVP
260 270 280 290 300
RRSVERAPGP HRSSEARGSL VTRIQPLVPP PSPPPSRRLS QPWPLQQHSG
310 320 330 340 350
PSRTVRRYPA TGANGQLMSN ALPSGLELRD SSPQAAHVNH LSPPWGLNLT
360 370 380 390 400
EKIKKIKVVF TPTICKQTCA RGRCANSCEK GDTTTLYSQG GHGHDPKSGF
410 420 430 440 450
RIYFCQIPCL NGGRCIGRDE CWCPANSTGK FCHLPVPQPD REPAGRGSRH
460 470 480 490 500
RTLLEGPLKQ STFTLPLSNQ LASVNPSLVK VQIHHPPEAS VQIHQVARVR
510 520 530 540 550
GELDPVLEDN SVETRASRRP HGNLGHSPWA SNSIPARAGE APRPPPVLSR
560 570 580 590 600
HYGLLGQCYL STVNGQCANP LGELTSQEDC CGSVGTFWGV TSCAPCPPRP
610 620 630 640 650
AFPVIENGQL ECPQGYKRLN LSHCQDINEC LTLGLCKDSE CVNTRGSYLC
660 670 680 690 700
TCRPGLMLDP SRSRCVSDKA VSMQQGLCYR SLGSGTCTLP LVHRITKQIC
710 720 730 740 750
CCSRVGKAWG STCEQCPLPG TEAFREICPA GHGYTYSSSD IRLSMRKAEE
760 770 780 790 800
EELASPLREQ TEQSTAPPPG QAERQPLRAA TATWIEAETL PDKGDSRAVQ
810 820 830 840 850
ITTSAPHLPA RVPGDATGRP APSLPGQGIP ESPAEEQVIP SSDVLVTHSP
860 870 880 890 900
PDFDPCFAGA SNICGPGTCV SLPNGYRCVC SPGYQLHPSQ DYCTDIDECE
910 920 930 940 950
QPGVCSGGRC SNTEGSYHCE CDRGYIMVRK GHCQDINECR HPGTCPDGRC
960 970 980 990 1000
VNSPGSYTCL ACEEGYVGQS GSCVDVNECL TPGICTHGRC INMEGSFRCS
1010 1020 1030 1040 1050
CEPGYEVTPD KKGCRDVDEC ASRASCPTGL CLNTEGSFTC SACQSGYWVN
1060 1070 1080 1090 1100
EDGTACEDLD ECAFPGVCPT GVCTNTVGSF SCKDCDRGYR PNPLGNRCED
1110 1120 1130 1140 1150
VDECEGPQSS CRGGECKNTE GSYQCLCHQG FQLVNGTMCE DVNECVGEEH
1160 1170 1180 1190 1200
CAPHGECLNS LGSFFCLCAP GFASAEGGTR CQDVDECAAT DPCPGGHCVN
1210 1220 1230 1240 1250
TEGSFSCLCE TGFQPSPDSG ECLDIDECED REDPVCGAWR CENSPGSYRC
1260 1270 1280 1290 1300
ILDCQPGFYV APNGDCIDID ECANDTVCGN HGFCDNTDGS FRCLCDQGFE
1310 1320 1330 1340 1350
TSPSGWECVD VNECELMMAV CGDALCENVE GSFLCLCASD LEEYDAEEGH
1360 1370 1380 1390 1400
CRPRVAGAQR IPEVRTEDQA PSLIRMECYS EHNGGPPCSQ ILGQNSTQAE
1410 1420 1430 1440 1450
CCCTQGARWG KACAPCPSED SVEFSQLCPS GQGYIPVEGA WTFGQTMYTD
1460 1470 1480 1490 1500
ADECVLFGPA LCQNGRCLNI VPGYICLCNP GYHYDASSRK CQDHNECQDL
1510 1520 1530 1540 1550
ACENGECVNT EGSFHCLCNP PLTLDLSGQR CVNSTSSTED FPDHDIHMDI
1560 1570 1580 1590 1600
CWKKVTNDVC SQPLRGHHTT YTECCCQDGE AWSQQCALCP PRSSEVYAQL
1610 1620 1630 1640 1650
CNVARIEAER GAGIHFRPGY EYGPGLDDLP ENLYGPDGAP FYNYLGPEDT
1660 1670 1680 1690 1700
APEPPFSNPA SQPGDNTPVL EPPLQPSELQ PHYLASHSEP LASFEGLQAE
1710 1720 1730 1740 1750
ECGILNGCEN GRCVRVREGY TCDCFEGFQL DAAHMACVDV NECEDLNGPA
1760 1770 1780
ALCAHGHCEN TEGSYRCHCS PGYVAEPGPP HCAAKE
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO08999 | LTBP2_MOUSE | Latent-transforming growth factor b... | Ltbp2 | 1,813 | Annotation score: | ||
E9Q1D6 | E9Q1D6_MOUSE | Latent-transforming growth factor b... | Ltbp2 | 1,766 | Annotation score: | ||
E9QNQ3 | E9QNQ3_MOUSE | Latent-transforming growth factor b... | Ltbp2 | 1,809 | Annotation score: | ||
F6UFW9 | F6UFW9_MOUSE | Latent-transforming growth factor b... | Ltbp2 | 204 | Annotation score: | ||
F6XGT5 | F6XGT5_MOUSE | Latent-transforming growth factor b... | Ltbp2 | 307 | Annotation score: | ||
F6WSP3 | F6WSP3_MOUSE | Latent-transforming growth factor b... | Ltbp2 | 183 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC122310 Genomic DNA No translation available. BC119785 mRNA Translation: AAI19786.1 |
RefSeqi | NP_038617.3, NM_013589.3 |
Genome annotation databases
Ensembli | ENSMUST00000110254; ENSMUSP00000105883; ENSMUSG00000002020 |
GeneIDi | 16997 |
KEGGi | mmu:16997 |
UCSCi | uc011ypd.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC122310 Genomic DNA No translation available. BC119785 mRNA Translation: AAI19786.1 |
RefSeqi | NP_038617.3, NM_013589.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 157, 129 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000110254; ENSMUSP00000105883; ENSMUSG00000002020 |
GeneIDi | 16997 |
KEGGi | mmu:16997 |
UCSCi | uc011ypd.1, mouse |
Organism-specific databases
CTDi | 4053 |
MGIi | MGI:99502, Ltbp2 |
Phylogenomic databases
GeneTreei | ENSGT00940000160884 |
OrthoDBi | 1174178at2759 |
Miscellaneous databases
BioGRID-ORCSi | 16997, 0 hits in 12 CRISPR screens |
ChiTaRSi | Ltbp2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000002020, Expressed in fibroblast and 154 other tissues |
Family and domain databases
Gene3Di | 3.90.290.10, 4 hits |
InterProi | View protein in InterPro IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR017878, TB_dom IPR036773, TB_dom_sf |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF07645, EGF_CA, 15 hits PF12661, hEGF, 1 hit PF00683, TB, 4 hits |
SMARTi | View protein in SMART SM00181, EGF, 19 hits SM00179, EGF_CA, 17 hits |
SUPFAMi | SSF57184, SSF57184, 5 hits SSF57581, SSF57581, 4 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 10 hits PS00022, EGF_1, 2 hits PS01186, EGF_2, 10 hits PS50026, EGF_3, 14 hits PS01187, EGF_CA, 7 hits PS51364, TB, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q0VD84_MOUSE | |
Accessioni | Q0VD84Primary (citable) accession number: Q0VD84 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 5, 2006 |
Last sequence update: | September 5, 2006 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |