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Protein

Alkaline phosphatase

Gene

Alpi

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
LigandMagnesiumUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline phosphataseUniRule annotation (EC:3.1.3.1UniRule annotation)
Gene namesi
Name:AlpiImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1924018 Alpi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500417882820 – 553Alkaline phosphataseSequence analysisAdd BLAST534

Proteomic databases

PeptideAtlasiQ0VD75
PRIDEiQ0VD75

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ0VD75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alkaline phosphatase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG4126 Eukaryota
COG1785 LUCA
HOGENOMiHOG000099118
HOVERGENiHBG007345

Family and domain databases

CDDicd16012 ALP, 1 hit
Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR001952 Alkaline_phosphatase
IPR018299 Alkaline_phosphatase_AS
IPR017850 Alkaline_phosphatase_core_sf
PANTHERiPTHR11596 PTHR11596, 1 hit
PfamiView protein in Pfam
PF00245 Alk_phosphatase, 1 hit
PRINTSiPR00113 ALKPHPHTASE
SMARTiView protein in SMART
SM00098 alkPPc, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit
PROSITEiView protein in PROSITE
PS00123 ALKALINE_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Fragment.

Q0VD75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
QGDWVLLLFL GLRIHLSFGI IPAEEENPAF WNKKAAEALD AVKKLQPIQT
60 70 80 90 100
SAKNLIIFLG DGMGVPTVTA TRILKGQLEG HLGPETPLAM DLFPYMALSK
110 120 130 140 150
TYNVDRQVPD SAGTATAYLC GVKANYKTIG LSAAARLDQC NTTFGNEVFS
160 170 180 190 200
VMYRAKKAGK SVGVVTTTRV QHASPAGTYA HTVNRNWYSD AEMPASALQD
210 220 230 240 250
GCKDIATQLI SNMDIDVILG GGRKFMFPKG TPDPEYPSDS NQSGTRLDDQ
260 270 280 290 300
NLVQTWLSKH QGARYVWNRS ELIQASQDPA VTHLMGLFEP TEMKYDANRN
310 320 330 340 350
PSVDPSLAEM TEVAVRMLSR NPQGFYLFVE GGRIDQGHHA GTAYLALTEA
360 370 380 390 400
VMFDSAIEKA SQLTNEKDTL ILITADHSHV FAFGGYTLRG TSIFGLAPLK
410 420 430 440 450
ALDDKSYTSI LYGNGPGYEL KSGNRPNVTE AQSVDPNYKQ QAAVPLSSET
460 470 480 490 500
HGGEDVAIFA RGPQAHLVHG VQEQNYIAHV MAFAGCLEPY TDCGLAPPAG
510 520 530 540 550
QSPVITPGQA TTTNNAAGQA TTTNNAAGQA TVLLSLQLLV SMLLLVGTAM

VVS
Length:553
Mass (Da):59,429
Last modified:September 5, 2006 - v1
Checksum:i4F8F24AD4F761EFE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119800 mRNA Translation: AAI19801.1
UniGeneiMm.58068

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119800 mRNA Translation: AAI19801.1
UniGeneiMm.58068

3D structure databases

ProteinModelPortaliQ0VD75
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ0VD75
PRIDEiQ0VD75

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1924018 Alpi

Phylogenomic databases

eggNOGiKOG4126 Eukaryota
COG1785 LUCA
HOGENOMiHOG000099118
HOVERGENiHBG007345

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

CDDicd16012 ALP, 1 hit
Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR001952 Alkaline_phosphatase
IPR018299 Alkaline_phosphatase_AS
IPR017850 Alkaline_phosphatase_core_sf
PANTHERiPTHR11596 PTHR11596, 1 hit
PfamiView protein in Pfam
PF00245 Alk_phosphatase, 1 hit
PRINTSiPR00113 ALKPHPHTASE
SMARTiView protein in SMART
SM00098 alkPPc, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit
PROSITEiView protein in PROSITE
PS00123 ALKALINE_PHOSPHATASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ0VD75_MOUSE
AccessioniPrimary (citable) accession number: Q0VD75
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: June 20, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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