UniProtKB - Q0VD22 (STK33_BOVIN)
Protein
Serine/threonine-protein kinase 33
Gene
STK33
Organism
Bos taurus (Bovine)
Status
Functioni
Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity).By similarity
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 145 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 238 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 122 – 130 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
GO - Biological processi
- mitotic DNA damage checkpoint Source: GO_Central
- signal transduction in response to DNA damage Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:STK33 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Other locations
- perinuclear region By similarity
Nucleus
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000278476 | 1 – 486 | Serine/threonine-protein kinase 33Add BLAST | 486 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 407 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Autophosphorylated.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q0VD22 |
PRIDEi | Q0VD22 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000011910, Expressed in spermatid and 10 other tissues |
Interactioni
Subunit structurei
Interacts with VIME.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000042938 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 116 – 381 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 266 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0032, Eukaryota |
HOGENOMi | CLU_000288_63_0_1 |
InParanoidi | Q0VD22 |
OMAi | HIRMDNG |
OrthoDBi | 330091at2759 |
TreeFami | TF314166 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
Q0VD22-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADSSCGKKS TKCPHCSSAS QKNALCICSC KTKLSPMSVV EMSQTSSTGS
60 70 80 90 100
SEFIVSPEKR KEKGASKDVT SGKDSPSKSS NIERKPSQQQ WGRGNFTEGK
110 120 130 140 150
VPHIRMDNGA ALQEIYTFGR ILGQGSFGMV IEAIDKERET KWAIKKVNKE
160 170 180 190 200
KAGSSAVKLL EREVDILKSV KHEHIIHLEQ VFETPKKMYL VMELCEDGEL
210 220 230 240 250
KEILERKGHF SENETRWIIQ SLASAIAYLH NKDIVHRDLK LENIMVKSSF
260 270 280 290 300
IDANNEMNLN IKVTDFGLAV KKHGRSEVML QTTCGTPIYM APEVINAHDY
310 320 330 340 350
SQQCDIWSIG VIMYILLCGK APFMASSEEK LFELIKKGEL HFKNSIWNSI
360 370 380 390 400
SDCAKSVLKQ LMKVDPAHRI TAKELLDNQW LTGNTVSSAR PTNVLEMMKE
410 420 430 440 450
WKNNPESDEE STTDQRDSRS GQEESKVYQP SRNVPDVSNS SDEEEGKQVG
460 470 480
RTNKTCRKNN CFISPNCEIP SQHLEHFCNS FFVVGL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC119877 mRNA Translation: AAI19878.1 |
RefSeqi | NP_001069376.1, NM_001075908.1 |
Genome annotation databases
GeneIDi | 528309 |
KEGGi | bta:528309 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC119877 mRNA Translation: AAI19878.1 |
RefSeqi | NP_001069376.1, NM_001075908.1 |
3D structure databases
SMRi | Q0VD22 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000042938 |
Proteomic databases
PaxDbi | Q0VD22 |
PRIDEi | Q0VD22 |
Genome annotation databases
GeneIDi | 528309 |
KEGGi | bta:528309 |
Organism-specific databases
CTDi | 65975 |
Phylogenomic databases
eggNOGi | KOG0032, Eukaryota |
HOGENOMi | CLU_000288_63_0_1 |
InParanoidi | Q0VD22 |
OMAi | HIRMDNG |
OrthoDBi | 330091at2759 |
TreeFami | TF314166 |
Gene expression databases
Bgeei | ENSBTAG00000011910, Expressed in spermatid and 10 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STK33_BOVIN | |
Accessioni | Q0VD22Primary (citable) accession number: Q0VD22 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 20, 2007 |
Last sequence update: | September 5, 2006 | |
Last modified: | February 10, 2021 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families