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Protein

Gamma-sarcoglycan

Gene

SGCG

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-sarcoglycan
Short name:
Gamma-SG
Gene namesi
Name:SGCG
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Organism-specific databases

VGNCiVGNC:34539 SGCG

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei38 – 58Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini59 – 291ExtracellularSequence analysisAdd BLAST233

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002851231 – 291Gamma-sarcoglycanAdd BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi265 ↔ 290Sequence analysis
Disulfide bondi267 ↔ 283Sequence analysis

Post-translational modificationi

Disulfide bonds are present.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ0VCU7

Expressioni

Gene expression databases

BgeeiENSBTAG00000001865

Interactioni

Subunit structurei

Interacts with the syntrophin SNTA1. Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans. Interacts with FLNC (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002431

Structurei

3D structure databases

SMRiQ0VCU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3950 Eukaryota
ENOG4111GCH LUCA
GeneTreeiENSGT00390000017950
HOGENOMiHOG000007853
HOVERGENiHBG008669
InParanoidiQ0VCU7
KOiK12564
OMAiDAETVCL
OrthoDBiEOG091G11VY
TreeFamiTF313538

Family and domain databases

InterProiView protein in InterPro
IPR006875 Sarcoglycan
IPR027660 SGCG
PANTHERiPTHR12939:SF4 PTHR12939:SF4, 1 hit
PfamiView protein in Pfam
PF04790 Sarcoglycan_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q0VCU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVREQYTTIT EGTHIERPEN QAVYKIGIYG WRKRCLYLFV LLLLIVLLVN
60 70 80 90 100
FALTIWILRV MWFSPVGMGH LHVTADGLHL EGESEFLFPL YVKEIRSRVD
110 120 130 140 150
SSLLLQSTQN VTMNARNTEG EVTGRLKVGP QMVEVQSQQF QIHSKDGKPL
160 170 180 190 200
FTVDEEKVMV GTDKLRVTGP EGALFEHSVE TPLVRPDPPQ DLRLESPTRS
210 220 230 240 250
LSMDAPKGIH IQAPAGKIEA LTQMDIVLQS SDGTVVLDAE TVCLPELALG
260 270 280 290
SQGPAGSSQG LYEVCVCPDG KLYLSVAGMG TTCHEHSHLC L
Length:291
Mass (Da):32,179
Last modified:September 5, 2006 - v1
Checksum:i1DA382DE5132CEDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119990 mRNA Translation: AAI19991.1
RefSeqiNP_001068712.1, NM_001075244.1
XP_010809098.1, XM_010810796.1
UniGeneiBt.2974

Genome annotation databases

EnsembliENSBTAT00000002431; ENSBTAP00000002431; ENSBTAG00000001865
GeneIDi506155
KEGGibta:506155

Similar proteinsi

Entry informationi

Entry nameiSGCG_BOVIN
AccessioniPrimary (citable) accession number: Q0VCU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 5, 2006
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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