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UniProtKB - Q0VCA7 (OXSM_BOVIN)
Protein
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
Gene
OXSM
Organism
Bos taurus (Bovine)
Status
Functioni
May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
By similarityCatalytic activityi
- EC:2.3.1.41By similarityThis reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
Activity regulationi
Inhibited by cerulenin.By similarity
: fatty acid biosynthesis Pathwayi
This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC
GO - Biological processi
- fatty acid biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
UniPathwayi | UPA00094 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrialCurated (EC:2.3.1.41By similarity)Alternative name(s): Beta-ketoacyl-ACP synthase |
Gene namesi | Name:OXSM |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 28 | MitochondrionSequence analysisAdd BLAST | 28 | |
ChainiPRO_0000310304 | 29 – 460 | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrialAdd BLAST | 432 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 110 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 110 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 114 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 175 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 175 | N6-succinyllysine; alternateBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | Q0VCA7 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1394, Eukaryota |
InParanoidi | Q0VCA7 |
OrthoDBi | 1014523at2759 |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR017568, 3-oxoacyl-ACP_synth-2 IPR000794, Beta-ketoacyl_synthase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
PIRSFi | PIRSF000447, KAS_II, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR03150, fabF, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q0VCA7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSDGLQIFL RITKCHLIHA RSCQRLVNER RFLATAPAPG LRRRVVITGI
60 70 80 90 100
GLVTPLGVGT QLVWDRLVRG ESGIVSLVGD EYQSIPCSVA AYVPRGCDEG
110 120 130 140 150
QFNEQNFVPK SDTKSMSPPT VMAIAAAELA LKDAGWHPQS EADQAATGVA
160 170 180 190 200
IGMGMVPLEV ISETALTFQT KGYSKVSPFF VPKILVNMAS GQVSIRHKLK
210 220 230 240 250
GPNHAVSTAC TTGAHAVGDS FRFVAHGDAD VMVAGGTDSC ISPLSLAGFA
260 270 280 290 300
RARALSTNTD PKSACRPFHP QRDGFVMGEG AAVLVLEEHR HALRRGARVY
310 320 330 340 350
AEIVGYGLSG DAGHITAPDP GGEGAFRCMA AAVKDAGIQP EEVSYINAHA
360 370 380 390 400
TSTPLGDAAE NKAIKQLFKD HAHVLAVSST KGATGHLLGT AGAAEAAFTA
410 420 430 440 450
LACYHRKLPP TLNLDCTEPH FDLNYVPLKA QEWKAENRRI ALTNSFGFGG
460
TNATLCIAGM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC120268 mRNA Translation: AAI20269.1 |
RefSeqi | NP_001069092.1, NM_001075624.2 |
Genome annotation databases
GeneIDi | 513530 |
KEGGi | bta:513530 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC120268 mRNA Translation: AAI20269.1 |
RefSeqi | NP_001069092.1, NM_001075624.2 |
3D structure databases
SMRi | Q0VCA7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000009250 |
Proteomic databases
PaxDbi | Q0VCA7 |
Genome annotation databases
GeneIDi | 513530 |
KEGGi | bta:513530 |
Organism-specific databases
CTDi | 54995 |
Phylogenomic databases
eggNOGi | KOG1394, Eukaryota |
InParanoidi | Q0VCA7 |
OrthoDBi | 1014523at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00094 |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR017568, 3-oxoacyl-ACP_synth-2 IPR000794, Beta-ketoacyl_synthase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
PIRSFi | PIRSF000447, KAS_II, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR03150, fabF, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OXSM_BOVIN | |
Accessioni | Q0VCA7Primary (citable) accession number: Q0VCA7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | September 5, 2006 | |
Last modified: | December 2, 2020 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families