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Protein

Suppressor of cytokine signaling 4

Gene

SOCS4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processGrowth regulation, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 4
Short name:
SOCS-4
Gene namesi
Name:SOCS4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Organism-specific databases

VGNCiVGNC:35122 SOCS4

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002630671 – 440Suppressor of cytokine signaling 4Add BLAST440

Proteomic databases

PaxDbiQ0VC91
PRIDEiQ0VC91

Expressioni

Gene expression databases

BgeeiENSBTAG00000021988

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029320

Structurei

3D structure databases

ProteinModelPortaliQ0VC91
SMRiQ0VC91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini286 – 381SH2PROSITE-ProRule annotationAdd BLAST96
Domaini376 – 425SOCS boxPROSITE-ProRule annotationAdd BLAST50

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000027791
HOVERGENiHBG054138
InParanoidiQ0VC91
KOiK04697
OMAiESCSDAE
OrthoDBiEOG091G0EQ0
TreeFamiTF321368

Family and domain databases

CDDicd10385 SH2_SOCS4, 1 hit
cd03738 SOCS_SOCS4, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR028416 SOCS4
IPR022252 SOCS4/SOCS5_dom
IPR035864 SOCS4_SH2
IPR037342 SOCS4_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44282:SF2 PTHR44282:SF2, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF12610 SOCS, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q0VC91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENSESNSK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESCSDAE
60 70 80 90 100
TVSAIEKTEV PLRSQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG
110 120 130 140 150
QCFPIKNCSS RHSSGLPSKR KIHISELMLD KCPFPPRSDL AFRWHFIKRH
160 170 180 190 200
TAPISPKSDE WVSTDLSQSE LRDGQLKQRR NMEEVSCFSH TSVQPCVITS
210 220 230 240 250
NNSSGRGGPG TDSIVNLASN NSIEDSDMDS DDEIITLCTS SRKRNKPKWE
260 270 280 290 300
IDEEILQLET PPKYHTQIDY VHCLVPDLLQ INNNPCYWGV MDKYAAEALL
310 320 330 340 350
EGKPEGTFLL RDSAQEDYLF SVSFRRYSRS LHARIEQWNH NFSFDAHDPC
360 370 380 390 400
VFHSPDITGL LEHYKDPSAC MFFEPLLSTP LIRTFPFSLQ HICRTVICNC
410 420 430 440
TTYDGIDALP IPSSMKLYLK EYHYKSKVRV LRIDAPEQQC
Length:440
Mass (Da):50,218
Last modified:September 5, 2006 - v1
Checksum:i51CD9ABC1758A54A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120292 mRNA Translation: AAI20293.1
RefSeqiNP_001069686.1, NM_001076218.2
UniGeneiBt.22739

Genome annotation databases

EnsembliENSBTAT00000029320; ENSBTAP00000029320; ENSBTAG00000021988
GeneIDi540412
KEGGibta:540412

Similar proteinsi

Entry informationi

Entry nameiSOCS4_BOVIN
AccessioniPrimary (citable) accession number: Q0VC91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 5, 2006
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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