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Protein

Palmitoyltransferase ZDHHC20

Gene

ZDHHC20

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation. Has a preference for acyl-CoA with C16 fatty acid chains. Can also utilize acyl-CoA with C14 and C18 fatty acid chains.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei29Important for selectivity toward medium-length fatty acidsBy similarity1
Metal bindingi128Zinc 1By similarity1
Metal bindingi131Zinc 1By similarity1
Binding sitei135SubstrateBy similarity1
Metal bindingi141Zinc 1By similarity1
Metal bindingi142Zinc 2By similarity1
Metal bindingi145Zinc 2By similarity1
Metal bindingi148Zinc 1By similarity1
Metal bindingi155Zinc 2By similarity1
Active sitei156S-palmitoyl cysteine intermediateBy similarity1
Metal bindingi162Zinc 2By similarity1
Sitei181Important for selectivity toward medium-length fatty acidsBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC20 (EC:2.3.1.225By similarity)
Alternative name(s):
Zinc finger DHHC domain-containing protein 20
Short name:
DHHC-20
Gene namesi
Name:ZDHHC20
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Organism-specific databases

VGNCiVGNC:37136 ZDHHC20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14LumenalBy similarityAdd BLAST14
Transmembranei15 – 35HelicalBy similarityAdd BLAST21
Topological domaini36 – 53CytoplasmicBy similarityAdd BLAST18
Transmembranei54 – 74HelicalBy similarityAdd BLAST21
Topological domaini75 – 169LumenalBy similarityAdd BLAST95
Transmembranei170 – 190HelicalBy similarityAdd BLAST21
Topological domaini191 – 207CytoplasmicBy similarityAdd BLAST17
Transmembranei208 – 231HelicalBy similarityAdd BLAST24
Topological domaini232 – 365LumenalBy similarityAdd BLAST134

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002692301 – 365Palmitoyltransferase ZDHHC20Add BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei305PhosphoserineBy similarity1
Modified residuei330PhosphoserineBy similarity1

Post-translational modificationi

Autopalmitoylated (in vitro).By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ0VC89
PRIDEiQ0VC89

Expressioni

Gene expression databases

BgeeiENSBTAG00000006177

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008119

Structurei

3D structure databases

SMRiQ0VC89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 176DHHCPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni140 – 143Substrate bindingBy similarity4

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1315 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00880000137864
HOGENOMiHOG000234777
HOVERGENiHBG055108
InParanoidiQ0VC89
KOiK20028
OMAiSRTIRYC
OrthoDBiEOG091G0AXR
TreeFamiTF316044

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q0VC89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPCTLWRCC QRTVGWVPVL FITFVVVWSY YAYVVELCVF TLSGNGENGK
60 70 80 90 100
AVVYLVAFHL FFVMFVWSYW MTIFTSPASP SKEFCLSNSE KERYEKEFSQ
110 120 130 140 150
ERQQEILRRA ARDLPIYTTS ASKTVRYCER CQLIKPDRAH HCSACDMCIL
160 170 180 190 200
KMDHHCPWVN NCVGFSNYKF FLLFLFYSLL YCLFVATTVL QYFIKFWTNE
210 220 230 240 250
LTDTRAKFHV LFLFFVSTMF FISVLSLLSY HCWLVGKNRT TIESFRAPMF
260 270 280 290 300
SYGTDGNGFS LGCSKNWRQV FGDEKKYWLL PVFSSQGDGC SFPTRLVGTD
310 320 330 340 350
PEQASVSNQS ESARSIGSNQ PFPIKPLSES KNRLLDSDPQ WLESGSEEGV
360
GGSGTNNHVT VAIEN
Length:365
Mass (Da):41,907
Last modified:September 5, 2006 - v1
Checksum:iB6C65283C2308463
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120294 mRNA Translation: AAI20295.1
RefSeqiNP_001069856.1, NM_001076388.2
XP_005213858.1, XM_005213801.1
XP_005213859.1, XM_005213802.1
UniGeneiBt.74269

Genome annotation databases

EnsembliENSBTAT00000008119; ENSBTAP00000008119; ENSBTAG00000006177
GeneIDi615659
KEGGibta:615659

Similar proteinsi

Entry informationi

Entry nameiZDH20_BOVIN
AccessioniPrimary (citable) accession number: Q0VC89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 5, 2006
Last modified: June 20, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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