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Protein

Adenosine receptor A3

Gene

ADORA3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-417973 Adenosine P1 receptors
R-BTA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A3
Gene namesi
Name:ADORA3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:54876 ADORA3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14ExtracellularBy similarityAdd BLAST14
Transmembranei15 – 37Helical; Name=1By similarityAdd BLAST23
Topological domaini38 – 48CytoplasmicBy similarityAdd BLAST11
Transmembranei49 – 72Helical; Name=2By similarityAdd BLAST24
Topological domaini73 – 84ExtracellularBy similarityAdd BLAST12
Transmembranei85 – 106Helical; Name=3By similarityAdd BLAST22
Topological domaini107 – 126CytoplasmicBy similarityAdd BLAST20
Transmembranei127 – 148Helical; Name=4By similarityAdd BLAST22
Topological domaini149 – 176ExtracellularBy similarityAdd BLAST28
Transmembranei177 – 197Helical; Name=5By similarityAdd BLAST21
Topological domaini198 – 230CytoplasmicBy similarityAdd BLAST33
Transmembranei231 – 254Helical; Name=6By similarityAdd BLAST24
Topological domaini255 – 260ExtracellularBy similarity6
Transmembranei261 – 283Helical; Name=7By similarityAdd BLAST23
Topological domaini284 – 317CytoplasmicBy similarityAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1287626

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002900081 – 317Adenosine receptor A3Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi83 ↔ 165PROSITE-ProRule annotation
Lipidationi302S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

Phosphorylation on Thr-315 and Ser-316 may be crucial for rapid desensitization. Phosphorylation on Thr-315 may be necessary for phosphorylation on Ser-316 to occur.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ0VC81
PRIDEiQ0VC81

Expressioni

Gene expression databases

BgeeiENSBTAG00000007642 Expressed in 10 organ(s), highest expression level in spleen

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010057

Chemistry databases

BindingDBiQ0VC81

Structurei

3D structure databases

ProteinModelPortaliQ0VC81
SMRiQ0VC81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00550000074524
HOGENOMiHOG000015770
HOVERGENiHBG106962
InParanoidiQ0VC81
KOiK04268
OMAiTTQRRIW
OrthoDBiEOG091G0I3U
TreeFamiTF325296

Family and domain databases

InterProiView protein in InterPro
IPR000466 Adeno_A3_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00555 ADENOSINEA3R
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q0VC81-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVNSTAVSL ASVTYISVEI LIGLCAIVGN VLVIWVVKLN PSLQTTTFYF
60 70 80 90 100
IVSLALADIA VGVLVMPLAI VISLGVTIHF YSCLLMTCLL MIFTHASIMS
110 120 130 140 150
LLAIAVDRYL RVKLTVRYRR VTTQRRIWLA LGLCWLVSFL VGLTPMFGWN
160 170 180 190 200
MKLSSADKNL TFLPCQFRSV MRMDYMVYFS FFTWILIPLV VMCAIYFDIF
210 220 230 240 250
YVIRNRLSQN FSGSKETGAF YGREFKTAKS LSLVLFLFAL SWLPLSIINC
260 270 280 290 300
IIYFNGEVPQ IVLYLGILLS HANSMMNPIV YAYKIKKFKE TYLLILKACV
310
ICQPSKSMDP SIEQTSE
Length:317
Mass (Da):35,911
Last modified:September 5, 2006 - v1
Checksum:i4843F7A27DDF0907
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120305 mRNA Translation: AAI20306.1
RefSeqiNP_001098081.1, NM_001104611.2
NP_001289697.1, NM_001302768.1
UniGeneiBt.40521

Genome annotation databases

EnsembliENSBTAT00000010057; ENSBTAP00000010057; ENSBTAG00000007642
GeneIDi780806
KEGGibta:780806

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120305 mRNA Translation: AAI20306.1
RefSeqiNP_001098081.1, NM_001104611.2
NP_001289697.1, NM_001302768.1
UniGeneiBt.40521

3D structure databases

ProteinModelPortaliQ0VC81
SMRiQ0VC81
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010057

Chemistry databases

BindingDBiQ0VC81
ChEMBLiCHEMBL1287626

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ0VC81
PRIDEiQ0VC81

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010057; ENSBTAP00000010057; ENSBTAG00000007642
GeneIDi780806
KEGGibta:780806

Organism-specific databases

CTDi140
VGNCiVGNC:54876 ADORA3

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00550000074524
HOGENOMiHOG000015770
HOVERGENiHBG106962
InParanoidiQ0VC81
KOiK04268
OMAiTTQRRIW
OrthoDBiEOG091G0I3U
TreeFamiTF325296

Enzyme and pathway databases

ReactomeiR-BTA-417973 Adenosine P1 receptors
R-BTA-418594 G alpha (i) signalling events

Gene expression databases

BgeeiENSBTAG00000007642 Expressed in 10 organ(s), highest expression level in spleen

Family and domain databases

InterProiView protein in InterPro
IPR000466 Adeno_A3_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00555 ADENOSINEA3R
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAA3R_BOVIN
AccessioniPrimary (citable) accession number: Q0VC81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: September 5, 2006
Last modified: November 7, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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