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Protein

Centrosomal protein of 126 kDa

Gene

Cep126

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Participate in cytokinesis (By similarity). Necessary for microtubules and mitotic spindle organization (By similarity). Involved in primary cilium formation (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 126 kDaImported
Gene namesi
Name:Cep126Imported
Synonyms:Kiaa1377
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2680221 Cep126

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951721 – 1103Centrosomal protein of 126 kDaAdd BLAST1103

Proteomic databases

MaxQBiQ0VBV7
PaxDbiQ0VBV7
PRIDEiQ0VBV7

PTM databases

iPTMnetiQ0VBV7
PhosphoSitePlusiQ0VBV7

Expressioni

Gene expression databases

BgeeiENSMUSG00000040729 Expressed in 178 organ(s), highest expression level in testis
CleanExiMM_AK129341
GenevisibleiQ0VBV7 MM

Interactioni

Subunit structurei

Interacts with DCTN1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042904

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili43 – 116Sequence analysisAdd BLAST74
Coiled coili182 – 222Sequence analysisAdd BLAST41

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFM4 Eukaryota
ENOG4111KUI LUCA
GeneTreeiENSGT00390000013786
HOGENOMiHOG000113165
HOVERGENiHBG081836
InParanoidiQ0VBV7
OMAiGTLYCTQ
OrthoDBiEOG091G0215
PhylomeDBiQ0VBV7
TreeFamiTF336632

Family and domain databases

InterProiView protein in InterPro
IPR028257 CEP126
PANTHERiPTHR31191 PTHR31191, 1 hit
PfamiView protein in Pfam
PF15352 K1377, 1 hit

Sequencei

Sequence statusi: Complete.

Q0VBV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAGRPGAQS AGAGVGAGPP DAPGARDGGG RPRPGAYLDM KIHLEKNLEE
60 70 80 90 100
ERQMLLQQQK LCRNRARKYF MESNRRRKAF EEKRQKQEER EYQIRERILQ
110 120 130 140 150
QRKQKFEEVT EKFQRAHVPV SQRRRAVFQN PVPPLEEALK QIQESNLKSE
160 170 180 190 200
VNIPLFHRPA TNWRAIDSAL PSTLSKNDHK HQKHLVRRIN RNKEMKENNI
210 220 230 240 250
ANLATNKNVF QLKLEETQKL LEDQHLSDLQ KFCDEVNQIT NSETLSSIDS
260 270 280 290 300
LEAGEREEIY ITLSMKPSTS TQQNSVPLQS ANLQAAHLDC FDEDKLSFSK
310 320 330 340 350
TQHINNWLTN LDAQNSQPVA SFSDILIKSN VLPSWECLNS KEQNPPALSR
360 370 380 390 400
TVGRTTRTTS DSMVFVCSPS VVALDKKGEN TAESNVVRAS DPTEGAVQRE
410 420 430 440 450
RPAQMESPTF KVSRAWTTAE SLTQETASFS VQERPSELTW ESRTASIPAS
460 470 480 490 500
SVTVLSPNLQ AGGPLAENNT QIKEIDPVQC SDKLDELKNM EHERINHLNC
510 520 530 540 550
NKEKYLFSPN FQTTCALQNS NSNDRKQKES GPSAALCNNP PDCDLPEQHS
560 570 580 590 600
IKHSVHEQNG VRLLKSILKK ESRYEHNYLR ALVMKQGFKF RHQKAETVRD
610 620 630 640 650
SIELTKQKGK GAEISKTSKK LRWFDESANL ENAVDDCHPV RNRAGMAPRW
660 670 680 690 700
LQRCHTNSGT YNLTSIPECP VHSAAGKKAK ADSVPENATD LGRYEIDSVP
710 720 730 740 750
LNSSVSLGFS FAKQAWSACR RGESKAPVHA SDSKTQKTKP QRGVKFTRRT
760 770 780 790 800
GSSKVQKGLV QNRKPTVSQP QTSSKANTVA QTQGKLIITH PPPKPPTNIK
810 820 830 840 850
SGKNMQVSPG QSAIPEHSQN VMTQSCLSPA SVLPTEYHLN QGTQESSLPF
860 870 880 890 900
SDTCSNLPAV SPALPTPYSS ECQTLAKANS NGTAFLKDGA VYCTHRSPVC
910 920 930 940 950
EESYQSFTHR NTEEESILPW RRRINGHQNE RTTDSTVTRR KQIVENKWKR
960 970 980 990 1000
LLEQKRKTSG SIGMKYTEQI THFGQNVPPS TTEQIQAPRG VKTEEVSDST
1010 1020 1030 1040 1050
SEFLVAENLM NSSVPEDEIL TAINSKHLQK PNLSQPTNVC ALSAEEQKIL
1060 1070 1080 1090 1100
KSLHHLDERL YYVQEAIRKN PSIKNTLQLI PLLSSQPRAS LSPDVGSTVQ

RKY
Length:1,103
Mass (Da):123,685
Last modified:September 5, 2006 - v1
Checksum:iAF5C4D62101FC7D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119072 mRNA Translation: AAI19073.1
BC120489 mRNA Translation: AAI20490.1
AK129341 mRNA Translation: BAC98151.1
CCDSiCCDS40534.1
RefSeqiNP_001038989.1, NM_001045524.1
UniGeneiMm.101341

Genome annotation databases

EnsembliENSMUST00000037397; ENSMUSP00000042904; ENSMUSG00000040729
GeneIDi234915
KEGGimmu:234915
UCSCiuc009odj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119072 mRNA Translation: AAI19073.1
BC120489 mRNA Translation: AAI20490.1
AK129341 mRNA Translation: BAC98151.1
CCDSiCCDS40534.1
RefSeqiNP_001038989.1, NM_001045524.1
UniGeneiMm.101341

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042904

PTM databases

iPTMnetiQ0VBV7
PhosphoSitePlusiQ0VBV7

Proteomic databases

MaxQBiQ0VBV7
PaxDbiQ0VBV7
PRIDEiQ0VBV7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037397; ENSMUSP00000042904; ENSMUSG00000040729
GeneIDi234915
KEGGimmu:234915
UCSCiuc009odj.1 mouse

Organism-specific databases

CTDi57562
MGIiMGI:2680221 Cep126
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IFM4 Eukaryota
ENOG4111KUI LUCA
GeneTreeiENSGT00390000013786
HOGENOMiHOG000113165
HOVERGENiHBG081836
InParanoidiQ0VBV7
OMAiGTLYCTQ
OrthoDBiEOG091G0215
PhylomeDBiQ0VBV7
TreeFamiTF336632

Miscellaneous databases

PROiPR:Q0VBV7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040729 Expressed in 178 organ(s), highest expression level in testis
CleanExiMM_AK129341
GenevisibleiQ0VBV7 MM

Family and domain databases

InterProiView protein in InterPro
IPR028257 CEP126
PANTHERiPTHR31191 PTHR31191, 1 hit
PfamiView protein in Pfam
PF15352 K1377, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCE126_MOUSE
AccessioniPrimary (citable) accession number: Q0VBV7
Secondary accession number(s): Q6ZPS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: September 5, 2006
Last modified: September 12, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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