Hif3a

Functionⁱ

Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:9840812, PubMed:11734856, PubMed:21546903). Plays a role in the development of the cardiorespiratory system (PubMed:18070924).4 Publications

Isoform 1: Acts as positive regulator of hypoxia-inducible gene expression. Associates to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters in a ARNT-dependent manner, and hence also participates in the transcriptional activation of reporter genes driven by HRE (PubMed:9840812).1 Publication

Isoform 2: Attenuates the ability of transcription factor HIF1A, EPAS1 and the HIF1A-ARNT complex to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. May act as a tumor suppressor (PubMed:11734856). May also be involved in apoptosis (PubMed:21546903).2 Publications

Isoform 3: Attenuates the ability of transcription factor HIF1A, EPAS1 and the HIF1A-ARNT complex to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation (PubMed:18070924). Plays also a role in the development of the lung and heart during embryonic and neonatal stages (PubMed:18070924).1 Publication

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from physical interactionⁱ
- 9840812
DNA-binding transcription factor activity
Source: MGI
Inferred from physical interactionⁱ
- 9840812
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein dimerization activity Source: InterPro
transcription coactivator activity Source: UniProtKB
transcription corepressor activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis Source: UniProtKB-KW
apoptotic process Source: UniProtKB-KW
positive regulation of transcription by RNA polymerase II Source: MGI
regulation of transcription by RNA polymerase II Source: MGI
response to hypoxia
Source: MGI
Inferred from direct assayⁱ
- 9840812
transcription by RNA polymerase II
Source: MGI
Inferred from physical interactionⁱ
- 9840812

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Repressor
Biological process	Angiogenesis, Apoptosis, Stress response, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1234158 Regulation of gene expression by Hypoxia-inducible Factor R-MMU-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-MMU-8951664 Neddylation

Reactomeⁱ

R-MMU-1234158 Regulation of gene expression by Hypoxia-inducible Factor
R-MMU-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-8951664 Neddylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hypoxia-inducible factor 3-alpha1 Publication Short name: HIF-3-alpha Short name: HIF3-alpha Alternative name(s): Basic-helix-loop-helix-PAS protein MOP7 HIF3-alpha-1 Inhibitory PAS domain protein1 Publication Short name: IPAS1 Publication Member of PAS protein 7 Neonatal and embryonic PAS protein1 Publication
Gene namesⁱ	Name:Hif3aImported Synonyms:Mop71 Publication, Nepas1 Publication
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:1859778 Hif3a

Keywords - Cellular componentⁱ

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice appeared outwardly normal and are viable and fertile. Show hypertrophy of the right atrium and ventricle, disarrangement of striated muscle fibers in the heart, and pulmonary hyperplasia (PubMed:18070924).1 Publication

Keywords - Diseaseⁱ

Tumor suppressor

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000284415	1 – 662	Hypoxia-inducible factor 3-alphaAdd BLAST		662

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	463	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residueⁱ	487	4-hydroxyprolineBy similarity	1
Cross-linkⁱ	565	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationⁱ

In normoxia, hydroxylated on Pro-487 in the oxygen-dependent degradation domain (ODD) by PHD. The hydroxylated proline promotes interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation (By similarity).By similarity

Ubiquitinated; ubiquitination occurs in a VHL- and oxygen-dependent pathway and subsequently targeted for proteasomal degradation.By similarity

Keywords - PTMⁱ

Hydroxylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	Q0VBL6
PaxDbⁱ	Q0VBL6
PRIDEⁱ	Q0VBL6

PTM databases

iPTMnetⁱ	Q0VBL6
PhosphoSitePlusⁱ	Q0VBL6

Expressionⁱ

Tissue specificityⁱ

Isoform 3 is expressed in endothelial cells of vessels and capillaries in alveoli of the neonatal lung (at protein level) (PubMed:18070924). Expressed in lung, brain, heart and kidney (PubMed:9840812). Isoform 2 is expressed in heart and lung (PubMed:12119283). Isoform 2 is highly expressed in the epithelial cell layer of the cornea with lower expression in the layers of ganglion cells, inner nuclear cells, and rods and cones of the retina (PubMed:11734856). Isoform 2 is expressed in the cerebellum only in the Purkinje cell layer (PubMed:11734856).4 Publications

Developmental stageⁱ

Isoform 3 is expressed in brain, heart, lung, liver and kidney at 15.5 dpc. Isoform 3 is expressed in heart, lung, liver and kidney at 18.5 dpc.1 Publication

Inductionⁱ

Isoform 2 is up-regulated in corneal epithelium cells under hypoxia (at protein level) (PubMed:11734856). Isoform 2 is up-regulated by hypoxia in a HIF1A-dependent manner (PubMed:12119283, PubMed:17355974). Isoform 3 is up-regulated by hypoxia (PubMed:18070924).4 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000004328 Expressed in 194 organ(s), highest expression level in fetal liver hematopoietic progenitor cell
CleanExⁱ	MM_HIF3A
ExpressionAtlasⁱ	Q0VBL6 baseline and differential
Genevisibleⁱ	Q0VBL6 MM

Interactionⁱ

Subunit structureⁱ

Isoform 1 interacts with ARNT (PubMed:9840812). Isoform 2 interacts with HIF1A (PubMed:11734856, PubMed:21546903). Isoform 2 interacts EPAS1 (PubMed:21546903). Isoform 2 interacts (via C-terminus domain) with BAD; the interaction reduces the binding between BAD and BAX (PubMed:21546903). Isoform 2 (via C-terminus domain) interacts with BCL2L2 and MCL1 (PubMed:21546903). Interacts with VHL (By similarity).By similarity3 Publications

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	207311, 6 interactors
STRINGⁱ	10090.ENSMUSP00000104132

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q0VBL6
SMRⁱ	Q0VBL6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	12 – 65	bHLHPROSITE-ProRule annotationAdd BLAST	54
Domainⁱ	80 – 150	PAS 1PROSITE-ProRule annotationAdd BLAST	71
Domainⁱ	225 – 295	PAS 2PROSITE-ProRule annotationAdd BLAST	71

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	75 – 98	Nuclear localization signal (isoform 2)1 PublicationAdd BLAST	24
Regionⁱ	228 – 272	Nuclear export signal (isoform 2)1 PublicationAdd BLAST	45
Regionⁱ	448 – 581	ODDAdd BLAST	134
Regionⁱ	450 – 501	NTADAdd BLAST	52

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	414 – 418	LRRLL		5
Motifⁱ	485 – 492	LAPYISMD		8

Domainⁱ

Isoform 2 contains a nuclear localization signal between amino acid positions 75 and 98. Isoform 2 contains a nuclear export signal between amino acid positions 228 and 272.1 Publication

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG3558 Eukaryota ENOG410YK57 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118788
HOGENOMⁱ	HOG000234306
HOVERGENⁱ	HBG060456
InParanoidⁱ	Q0VBL6
KEGG Orthology (KO) More...KOⁱ	K09096
OMAⁱ	FTHCEGR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0486

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR021537 HIF_alpha_subunit IPR036638 HLH_DNA-bd_sf IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold IPR013655 PAS_fold_3
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11413 HIF-1, 1 hit PF00989 PAS, 1 hit PF08447 PAS_3, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
TIGRFAMsⁱ	TIGR00229 sensory_box, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 2 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q0VBL6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDWDQDRSNT ELRKEKSRDA ARSRRSQETE VLYQLAHTLP FARGVSAHLD 
        60         70         80         90        100
KASIMRLTIS YLRMHRLCAA GEWNQVEKGG EPLDACYLKA LEGFVMVLTA 
       110        120        130        140        150
EGDMAYLSEN VSKHLGLSQL ELIGHSIFDF IHPCDQEELQ DALTPRPNLS 
       160        170        180        190        200
KKKLEAPTER HFSLRMKSTL TSRGRTLNLK AATWKVLHCS GHMRAYKPPA 
       210        220        230        240        250
QTSPAGSPRS EPPLQCLVLI CEAIPHPASL EPPLGRGAFL SRHSLDMKFT 
       260        270        280        290        300
YCDERIAEVA GYSPDDLIGC SAYEYIHALD SDAVSRSIHT LLSKGQAVTG 
       310        320        330        340        350
QYRFLARTGG YLWTQTQATV VSGGRGPQSE SIICVHFLIS RVEETGVVLS 
       360        370        380        390        400
LEQTEQHTRR PPRLSASSQK GIPGNSVDSP APRILAFLHP PALSEASLAA 
       410        420        430        440        450
DPRRFCSPDL RRLMAPILDG PPPAATPSTP QATRRPQSPL PADLPDKLTV 
       460        470        480        490        500
GLENAHRLST AQKNKTVETD LDIAQDPDTL DLEMLAPYIS MDDDFQLNSS 
       510        520        530        540        550
EQLPKVHRRP PRVARRPRAR SFHGLSPPIP EPSLLPRWGS DPRLNCSSPS 
       560        570        580        590        600
RGDRPTASLM PGTRKRALAQ SSEDKGLELL ETKPPKRSPR LEPGSFLLPP 
       610        620        630        640        650
LSLSFLLQGR QLPGNQQDPR APLVHSHEPL GLAPSLLSLC QHEETVQPRN 
       660 
RFPPAAGLGQ TH

Length:662

Mass (Da):73,044

Last modified:July 27, 2011 - v2

Checksum:ⁱD05E2B9CB2B63E4E

GO

Isoform 2 (identifier: Q0VBL6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MDWDQD → MALGLQRV
     72-119: EWNQVEKGGE...NVSKHLGLSQ → GKRGRATGRL...HNPTPGTNFS
     226-291: HPASLEPPLG...DAVSRSIHTL → QLPFHDGATL...WALNRKNCPG
     292-662: Missing.

« Hide

        10         20         30         40         50
MALGLQRVRS NTELRKEKSR DAARSRRSQE TEVLYQLAHT LPFARGVSAH 
        60         70         80         90        100
LDKASIMRLT ISYLRMHRLC AAGGKRGRAT GRLLPEGPGG FRHGTHRRGR 
       110        120        130        140        150
HGLPVGKCQQ APGPQSVDLC SSSLIHNPTP GTNFSLELIG HSIFDFIHPC 
       160        170        180        190        200
DQEELQDALT PRPNLSKKKL EAPTERHFSL RMKSTLTSRG RTLNLKAATW 
       210        220        230        240        250
KVLHCSGHMR AYKPPAQTSP AGSPRSEPPL QCLVLICEAI PQLPFHDGAT 
       260        270        280        290        300
LGLPQEKTPI STLFTPLWKA LLCLVKRWPV QVLQGKGTES SLPSWVLWAL 

NRKNCPG

Note: Mutagenesis of Lys-75, Arg-76, Arg-97 and Arg-98 increase strongly cytoplasmic localization. Mutagenesis of Pro-228, Pro-229, Leu-271 and Leu-272 increase strongly nuclear localization.1 Publication

Show »

Length:307

Mass (Da):33,990

Checksum:ⁱD89D3B225C9C3967

GO

Isoform 3 (identifier: Q0VBL6-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-6: MDWDQD → MALGLQRV

« Hide

        10         20         30         40         50
MALGLQRVRS NTELRKEKSR DAARSRRSQE TEVLYQLAHT LPFARGVSAH 
        60         70         80         90        100
LDKASIMRLT ISYLRMHRLC AAGEWNQVEK GGEPLDACYL KALEGFVMVL 
       110        120        130        140        150
TAEGDMAYLS ENVSKHLGLS QLELIGHSIF DFIHPCDQEE LQDALTPRPN 
       160        170        180        190        200
LSKKKLEAPT ERHFSLRMKS TLTSRGRTLN LKAATWKVLH CSGHMRAYKP 
       210        220        230        240        250
PAQTSPAGSP RSEPPLQCLV LICEAIPHPA SLEPPLGRGA FLSRHSLDMK 
       260        270        280        290        300
FTYCDERIAE VAGYSPDDLI GCSAYEYIHA LDSDAVSRSI HTLLSKGQAV 
       310        320        330        340        350
TGQYRFLART GGYLWTQTQA TVVSGGRGPQ SESIICVHFL ISRVEETGVV 
       360        370        380        390        400
LSLEQTEQHT RRPPRLSASS QKGIPGNSVD SPAPRILAFL HPPALSEASL 
       410        420        430        440        450
AADPRRFCSP DLRRLMAPIL DGPPPAATPS TPQATRRPQS PLPADLPDKL 
       460        470        480        490        500
TVGLENAHRL STAQKNKTVE TDLDIAQDPD TLDLEMLAPY ISMDDDFQLN 
       510        520        530        540        550
SSEQLPKVHR RPPRVARRPR ARSFHGLSPP IPEPSLLPRW GSDPRLNCSS 
       560        570        580        590        600
PSRGDRPTAS LMPGTRKRAL AQSSEDKGLE LLETKPPKRS PRLEPGSFLL 
       610        620        630        640        650
PPLSLSFLLQ GRQLPGNQQD PRAPLVHSHE PLGLAPSLLS LCQHEETVQP 
       660 
RNRFPPAAGL GQTH

Show »

Length:664

Mass (Da):73,122

Checksum:ⁱE47A38649E415D63

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3Z377	D3Z377_MOUSE	Hypoxia-inducible factor 3-alpha Hypoxia-inducible factor 3-alpha	Hif3a	152	Annotation score:
A0A0U1RQ59	A0A0U1RQ59_MOUSE	Hypoxia-inducible factor 3-alpha Hypoxia-inducible factor 3-alpha	Hif3a	76	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	345	T → N in BAE25907 (PubMed:16141072).Curated	1
Sequence conflictⁱ	449	T → A in AAC72734 (PubMed:9840812).Curated	1
Sequence conflictⁱ	449	T → A in AAF21782 (PubMed:9840812).Curated	1
Sequence conflictⁱ	449	T → A in AAI20588 (PubMed:15489334).Curated	1
Sequence conflictⁱ	449	T → A in BAF44519 (PubMed:18070924).Curated	1
Sequence conflictⁱ	477	P → S in AAC72734 (PubMed:9840812).Curated	1
Sequence conflictⁱ	477	P → S in AAF21782 (PubMed:9840812).Curated	1
Sequence conflictⁱ	477	P → S in AAI20588 (PubMed:15489334).Curated	1
Sequence conflictⁱ	477	P → S in BAF44519 (PubMed:18070924).Curated	1
Sequence conflictⁱ	484	M → I in BAE25907 (PubMed:16141072).Curated	1
Sequence conflictⁱ	582	T → I in AAC72734 (PubMed:9840812).Curated	1
Sequence conflictⁱ	582	T → I in AAF21782 (PubMed:9840812).Curated	1
Sequence conflictⁱ	613	P → L in AAC72734 (PubMed:9840812).Curated	1
Sequence conflictⁱ	613	P → L in AAF21782 (PubMed:9840812).Curated	1
Sequence conflictⁱ	613	P → L in AAI20588 (PubMed:15489334).Curated	1
Sequence conflictⁱ	613	P → L in BAF44519 (PubMed:18070924).Curated	1
Sequence conflictⁱ	651	R → H in AAC72734 (PubMed:9840812).Curated	1
Sequence conflictⁱ	651	R → H in BAF44519 (PubMed:18070924).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_024528	1 – 6	MDWDQD → MALGLQRV in isoform 2 and isoform 3. 2 Publications	6
Alternative sequenceⁱVSP_024529	72 – 119	EWNQV…LGLSQ → GKRGRATGRLLPEGPGGFRH GTHRRGRHGLPVGKCQQAPG PQSVDLCSSSLIHNPTPGTN FS in isoform 2. 1 PublicationAdd BLAST	48
Alternative sequenceⁱVSP_024530	226 – 291	HPASL…SIHTL → QLPFHDGATLGLPQEKTPIS TLFTPLWKALLCLVKRWPVQ VLQGKGTESSLPSWVLWALN RKNCPG in isoform 2. 1 PublicationAdd BLAST	66
Alternative sequenceⁱVSP_024531	292 – 662	Missing in isoform 2. 1 PublicationAdd BLAST	371

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF060194 mRNA Translation: AAC72734.1 AH008971 Genomic DNA Translation: AAF21782.1 AF416641 mRNA Translation: AAL39015.1 AB289606 mRNA Translation: BAF44519.1 AC148976 Genomic DNA No translation available. BC120587 mRNA Translation: AAI20588.1 AK144472 mRNA Translation: BAE25907.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS20860.1 [Q0VBL6-1] CCDS52045.1 [Q0VBL6-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001156422.1, NM_001162950.1 [Q0VBL6-3] NP_058564.2, NM_016868.3 [Q0VBL6-1]
UniGeneⁱ	Mm.135110

Genome annotation databases

Ensemblⁱ	ENSMUST00000037762; ENSMUSP00000048248; ENSMUSG00000004328 [Q0VBL6-1] ENSMUST00000108492; ENSMUSP00000104132; ENSMUSG00000004328 [Q0VBL6-3]
GeneIDⁱ	53417
KEGGⁱ	mmu:53417
UCSC genome browser More...UCSCⁱ	uc009fir.2 mouse [Q0VBL6-1] uc009fit.2 mouse [Q0VBL6-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q0VBL6	Hypoxia-inducible factor 3-alpha		RAT		662	UniRef90_Q0VBL6
UPI000A30D0EE		MUSPA		665
UPI000A31AB86		MUSCR		662
UPI000B4F6B44		MERUN		662
UPI000A304D6B		MUSPA		663
+1
Q0VBL6-2	Inhibitory PAS domain protein (Fragment)		MOUSE		65	UniRef90_Q0VBL6-2
Inhibitory PAS domain protein (Fragment)		MOUSE		18
Hypoxia-inducible factor 3-alpha (Fragment)		MOUSE		152
Q0VBL6-3	Hypoxia-inducible factor 3-alpha		RAT		662	UniRef90_Q0VBL6-3
hypoxia-inducible factor 3-alpha		MESAU		597
UPI0005ABAB34		MOUSE		608
UPI00042ACF05		PERMB		664
UPI000A316801		MUSCR		664
+8

Protein	Similar proteins		Species	Score	Length	Source
Q0VBL6	Hypoxia-inducible factor 3-alpha	)	HUMAN		669	UniRef50_Q9Y2N7
Hypoxia-inducible factor 3-alpha		RAT		662
Hypoxia inducible factor 3 subunit alpha		CALJA		719
Uncharacterized protein		Cebus capucinus imitator		670
Uncharacterized protein		AOTNA		670
+228
Q0VBL6-2	Isoform 4 of Hypoxia-inducible factor 3-alpha		HUMAN		363	UniRef50_Q9Y2N7-4
Uncharacterized protein		MACMU		307
Inhibitory PAS domain protein (Fragment)		MOUSE		65
UPI0008FAAA4F		CYPCA		296
UPI00064F5D86		ECHTE		354
+2

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF060194 mRNA Translation: AAC72734.1 AH008971 Genomic DNA Translation: AAF21782.1 AF416641 mRNA Translation: AAL39015.1 AB289606 mRNA Translation: BAF44519.1 AC148976 Genomic DNA No translation available. BC120587 mRNA Translation: AAI20588.1 AK144472 mRNA Translation: BAE25907.1
CCDSⁱ	CCDS20860.1 [Q0VBL6-1] CCDS52045.1 [Q0VBL6-3]
RefSeqⁱ	NP_001156422.1, NM_001162950.1 [Q0VBL6-3] NP_058564.2, NM_016868.3 [Q0VBL6-1]
UniGeneⁱ	Mm.135110

3D structure databases

ProteinModelPortalⁱ	Q0VBL6
SMRⁱ	Q0VBL6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	207311, 6 interactors
STRINGⁱ	10090.ENSMUSP00000104132

PTM databases

iPTMnetⁱ	Q0VBL6
PhosphoSitePlusⁱ	Q0VBL6

Proteomic databases

EPDⁱ	Q0VBL6
PaxDbⁱ	Q0VBL6
PRIDEⁱ	Q0VBL6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000037762; ENSMUSP00000048248; ENSMUSG00000004328 [Q0VBL6-1] ENSMUST00000108492; ENSMUSP00000104132; ENSMUSG00000004328 [Q0VBL6-3]
GeneIDⁱ	53417
KEGGⁱ	mmu:53417
UCSCⁱ	uc009fir.2 mouse [Q0VBL6-1] uc009fit.2 mouse [Q0VBL6-2]

Organism-specific databases

CTDⁱ	64344
MGIⁱ	MGI:1859778 Hif3a

Phylogenomic databases

eggNOGⁱ	KOG3558 Eukaryota ENOG410YK57 LUCA
GeneTreeⁱ	ENSGT00760000118788
HOGENOMⁱ	HOG000234306
HOVERGENⁱ	HBG060456
InParanoidⁱ	Q0VBL6
KOⁱ	K09096
OMAⁱ	FTHCEGR
OrthoDBⁱ	EOG091G0486

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1234158 Regulation of gene expression by Hypoxia-inducible Factor R-MMU-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-MMU-8951664 Neddylation

Reactomeⁱ

R-MMU-1234158 Regulation of gene expression by Hypoxia-inducible Factor
R-MMU-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-8951664 Neddylation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q0VBL6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000004328 Expressed in 194 organ(s), highest expression level in fetal liver hematopoietic progenitor cell
CleanExⁱ	MM_HIF3A
ExpressionAtlasⁱ	Q0VBL6 baseline and differential
Genevisibleⁱ	Q0VBL6 MM

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR021537 HIF_alpha_subunit IPR036638 HLH_DNA-bd_sf IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold IPR013655 PAS_fold_3
Pfamⁱ	View protein in Pfam PF11413 HIF-1, 1 hit PF00989 PAS, 1 hit PF08447 PAS_3, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
TIGRFAMsⁱ	TIGR00229 sensory_box, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HIF3A_MOUSE
Accessionⁱ	Q0VBL6Primary (citable) accession number: Q0VBL6 Secondary accession number(s): A1IM61 , E9QLB1, Q3UN40, Q8VHR1, Q9QX54, Q9Z2I5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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Hypoxia-inducible factor 3-alpha

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Functionⁱ

GO - Molecular functionⁱ

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Names & Taxonomyⁱ

Subcellular locationⁱ

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Keywords - Diseaseⁱ

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Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

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