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Protein

RNA-binding protein 15

Gene

Rbm15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:29535189). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:29535189). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (By similarity). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (PubMed:17283045, PubMed:17376872, PubMed:18981216, PubMed:25468569). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (By similarity). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (PubMed:18981216). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (PubMed:25468569). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (By similarity). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (By similarity). May be implicated in HOX gene regulation (By similarity).By similarity5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mRNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-binding protein 151 Publication
Alternative name(s):
One-twenty two protein 11 Publication
RNA-binding motif protein 151 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rbm151 PublicationImported
Synonyms:Kiaa42571 Publication, Ott11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443205 Rbm15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethality around E9.5 (PubMed:17376872, PubMed:18981216). Early embryos show growth retardation and incomplete closure of the notochord, as well as placental defects in the spongiotrophoblast and syncytiotrophoblast layers, resulting in an arrest of vascular branching morphogenesis (PubMed:18981216). Conditional knockout mice lacking Rbm15 within the hematopoietic compartment display a loss of peripheral B-cells due to a block in pro/pre-B differentiation, as well as a myeloid and megakaryocytic expansion in spleen and bone marrow (PubMed:17376872).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004446111 – 962RNA-binding protein 15Add BLAST962

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei108PhosphoserineBy similarity1
Modified residuei178PhosphoserineBy similarity1
Modified residuei207PhosphoserineBy similarity1
Modified residuei209PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki245Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei252PhosphoserineBy similarity1
Modified residuei256PhosphoserineBy similarity1
Modified residuei258PhosphoserineBy similarity1
Modified residuei265PhosphotyrosineBy similarity1
Modified residuei291PhosphoserineBy similarity1
Modified residuei293PhosphoserineBy similarity1
Modified residuei364PhosphoserineBy similarity1
Cross-linki405Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki419Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki444Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei449N6-acetyllysineBy similarity1
Modified residuei567PhosphothreonineBy similarity1
Modified residuei577Asymmetric dimethylarginine; alternate; by PRMT1By similarity1
Modified residuei577Omega-N-methylarginine; alternate; by PRMT1By similarity1
Modified residuei621PhosphoserineBy similarity1
Modified residuei655PhosphoserineBy similarity1
Modified residuei670PhosphoserineBy similarity1
Modified residuei674PhosphoserineBy similarity1
Modified residuei701PhosphoserineBy similarity1
Cross-linki745Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei768PhosphoserineBy similarity1
Modified residuei782PhosphoserineBy similarity1
Modified residuei936PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylated at Arg-577 by PRMT1, leading to promote ubiquitination by CNOT4 and subsequent degradation by the proteasome.By similarity
Ubiquitinated by CNOT4 following methylation at Arg-577 by PRMT1.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q0VBL3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q0VBL3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q0VBL3

PeptideAtlas

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PeptideAtlasi
Q0VBL3

PRoteomics IDEntifications database

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PRIDEi
Q0VBL3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000048109 Expressed in 252 organ(s), highest expression level in thymus

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:29535189). The MAC subcomplex is composed of METTL3 and METTL14 (PubMed:29535189). The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (PubMed:29535189). Also component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, VIRMA, RBM15, BCLAF1 and THRAP3 (By similarity). Interacts with RBPJ (PubMed:17283045). Interacts (via SPOC domain) with SETD1B (By similarity). Interacts with NXF1, the interaction is required to promote mRNA export (By similarity). Interacts with SF3B1 (By similarity).By similarity2 Publications

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q0VBL3, 3 interactors

Molecular INTeraction database

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MINTi
Q0VBL3

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000054424

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q0VBL3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q0VBL3

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini169 – 251RRM 1PROSITE-ProRule annotationAdd BLAST83
Domaini373 – 450RRM 2PROSITE-ProRule annotationAdd BLAST78
Domaini454 – 528RRM 3PROSITE-ProRule annotationAdd BLAST75
Domaini778 – 957SPOCPROSITE-ProRule annotationAdd BLAST180

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi60 – 165Gly-richPROSITE-ProRule annotationAdd BLAST106
Compositional biasi64 – 158Ser-richPROSITE-ProRule annotationAdd BLAST95
Compositional biasi284 – 288Poly-GlySequence analysis5
Compositional biasi315 – 323Poly-ProSequence analysis9
Compositional biasi587 – 591Poly-ProSequence analysis5
Compositional biasi615 – 733Arg-richPROSITE-ProRule annotationAdd BLAST119

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRM Spen family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0112 Eukaryota
ENOG410XSAC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158161

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000006547

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG082873

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q0VBL3

KEGG Orthology (KO)

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KOi
K13190

Identification of Orthologs from Complete Genome Data

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OMAi
VMIIVRV

Database of Orthologous Groups

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OrthoDBi
367857at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q0VBL3

TreeFam database of animal gene trees

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TreeFami
TF315637

Family and domain databases

Conserved Domains Database

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CDDi
cd12553 RRM1_RBM15, 1 hit
cd12555 RRM2_RBM15, 1 hit
cd12557 RRM3_RBM15, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.40.290.10, 1 hit
3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034470 RBM15_RRM1
IPR034472 RBM15_RRM2
IPR034473 RBM15_RRM3
IPR000504 RRM_dom
IPR016194 SPOC-like_C_dom_sf
IPR012921 SPOC_C
IPR010912 SPOC_met

Pfam protein domain database

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Pfami
View protein in Pfam
PF00076 RRM_1, 2 hits
PF07744 SPOC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00360 RRM, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF100939 SSF100939, 1 hit
SSF54928 SSF54928, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50102 RRM, 3 hits
PS50917 SPOC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q0VBL3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSAGREPLP RRSPRWRRAS PLCETSAGWR VSQLRRDDLR RPSTMKGKER
60 70 80 90 100
SPVKPKRSRG GEDSSSRGER SKKLGGSGGS NGSSSGKTDS GGSRRSLHLD
110 120 130 140 150
KSSSRGGSRE YETGGGSSSS RLHSYSSPST KNSSGGGESR SSSRGGGGES
160 170 180 190 200
RSSGAASSAP GGGDGVEYKT LKISELGSQL SDEAVEDGLF HEFKRFGDVS
210 220 230 240 250
VKISHLSGSG SGDERVAFVN FRRPEDARAA KHARGRLVLY DRPLKIEAVY
260 270 280 290 300
VSRRRSRSPL DKDAYAPSSS VVGTSVGSHR HAPGGGGGQR SLSPGGAALG
310 320 330 340 350
YRDYRLQQLA LGRLPPPPPP PLPRELERER DYPFYDRVRP AYSLEPRVGA
360 370 380 390 400
GAGAAPFREV DEISPEDDQR ANRTLFLGNL DITVTENDLR RAFDRFGVIT
410 420 430 440 450
EVDIKRPSRG QTSTYGFLKF ENLDMSHRAK LAMSGKIIIR NPIKIGYGKA
460 470 480 490 500
TPTTRLWVGG LGPWVPLAAL AREFDRFGTI RTIDYRKGDS WAYIQYESLD
510 520 530 540 550
AAHAAWTHMR GFPLGGPDRR LRVDFADTEH RYQQQYLQPL PLTHYELVTD
560 570 580 590 600
TFGHRAPDPL RSARDRTPPL LYRDRDRDLY TDSDWVPPPP PVRERSARAA
610 620 630 640 650
TSAVTAYEPL DSLDRRRDGW SLDRDRGDRD LPSSRDQPRK RRLPEESGGR
660 670 680 690 700
HLDRSPESER PRKQRHCTPS PDRSPELSSN RDRYNSDNDR SSRLLLLERS
710 720 730 740 750
SPVRDRRGSL EKSQSDKRDR KNSASAERDR KHRTAAPTEG KNPLKKEDRS
760 770 780 790 800
DGNAPSASTS SSKQKPPSQK QDGGTAPVAA SSPKLCLAWQ GMLLLKNSNF
810 820 830 840 850
PSNMHLLQGD LQVASSLLVE GSTGGKVAQL KITQRLRLDQ PKLDEVTRRI
860 870 880 890 900
KVAGPNGYAI LLAVPGSSDS RSSSSSATSD TAASTQRPLR NLVSYLKQKQ
910 920 930 940 950
AAGVISLPVG GNKDKENTGV LHAFPPCEFS QQFLDSPAKA LAKSEEDYLV
960
MIIVRAKLVN SG
Length:962
Mass (Da):105,722
Last modified:September 5, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD740EDBF23279C5D
GO
Isoform 2 (identifier: Q0VBL3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     956-962: AKLVNSG → GAS

Show »
Length:958
Mass (Da):105,267
Checksum:i51B979FDCC4F9D14
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH80828 differs from that shown. Contaminating sequence.Curated
The sequence BAD90348 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti41R → P in BAD90348 (Ref. 1) Curated1
Sequence conflicti78G → S in BAE40192 (PubMed:16141072).Curated1
Sequence conflicti157S → A in BAE38672 (PubMed:16141072).Curated1
Sequence conflicti619G → S in BAE40192 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059625956 – 962AKLVNSG → GAS in isoform 2. 7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK220162 mRNA Translation: BAD90348.1 Different initiation.
AC132405 Genomic DNA No translation available.
BC028452 mRNA Translation: AAH28452.1
BC051409 mRNA Translation: AAH51409.1
BC057038 mRNA Translation: AAH57038.1
BC080828 mRNA Translation: AAH80828.1 Sequence problems.
BC120590 mRNA Translation: AAI20591.1
BC137741 mRNA Translation: AAI37742.1
AK166271 mRNA Translation: BAE38672.1
AK168242 mRNA Translation: BAE40192.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS38590.1 [Q0VBL3-1]

NCBI Reference Sequences

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RefSeqi
NP_001039272.1, NM_001045807.1 [Q0VBL3-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.27966
Mm.472803

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000061772; ENSMUSP00000054424; ENSMUSG00000048109 [Q0VBL3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
229700

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:229700

UCSC genome browser

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UCSCi
uc008qwz.1 mouse [Q0VBL3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220162 mRNA Translation: BAD90348.1 Different initiation.
AC132405 Genomic DNA No translation available.
BC028452 mRNA Translation: AAH28452.1
BC051409 mRNA Translation: AAH51409.1
BC057038 mRNA Translation: AAH57038.1
BC080828 mRNA Translation: AAH80828.1 Sequence problems.
BC120590 mRNA Translation: AAI20591.1
BC137741 mRNA Translation: AAI37742.1
AK166271 mRNA Translation: BAE38672.1
AK168242 mRNA Translation: BAE40192.1
CCDSiCCDS38590.1 [Q0VBL3-1]
RefSeqiNP_001039272.1, NM_001045807.1 [Q0VBL3-1]
UniGeneiMm.27966
Mm.472803

3D structure databases

ProteinModelPortaliQ0VBL3
SMRiQ0VBL3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ0VBL3, 3 interactors
MINTiQ0VBL3
STRINGi10090.ENSMUSP00000054424

Proteomic databases

jPOSTiQ0VBL3
MaxQBiQ0VBL3
PaxDbiQ0VBL3
PeptideAtlasiQ0VBL3
PRIDEiQ0VBL3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061772; ENSMUSP00000054424; ENSMUSG00000048109 [Q0VBL3-1]
GeneIDi229700
KEGGimmu:229700
UCSCiuc008qwz.1 mouse [Q0VBL3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64783
MGIiMGI:2443205 Rbm15

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG0112 Eukaryota
ENOG410XSAC LUCA
GeneTreeiENSGT00940000158161
HOGENOMiHOG000006547
HOVERGENiHBG082873
InParanoidiQ0VBL3
KOiK13190
OMAiVMIIVRV
OrthoDBi367857at2759
PhylomeDBiQ0VBL3
TreeFamiTF315637

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Rbm15 mouse

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000048109 Expressed in 252 organ(s), highest expression level in thymus

Family and domain databases

CDDicd12553 RRM1_RBM15, 1 hit
cd12555 RRM2_RBM15, 1 hit
cd12557 RRM3_RBM15, 1 hit
Gene3Di2.40.290.10, 1 hit
3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034470 RBM15_RRM1
IPR034472 RBM15_RRM2
IPR034473 RBM15_RRM3
IPR000504 RRM_dom
IPR016194 SPOC-like_C_dom_sf
IPR012921 SPOC_C
IPR010912 SPOC_met
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
PF07744 SPOC, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF100939 SSF100939, 1 hit
SSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits
PS50917 SPOC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBM15_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0VBL3
Secondary accession number(s): A0PJG5
, Q3THK4, Q3TLX0, Q571M7, Q66JP8, Q6PGG1, Q7TT82
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2018
Last sequence update: September 5, 2006
Last modified: January 16, 2019
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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