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Protein

Keratin, type II cytoskeletal 80

Gene

Krt80

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei334Stutter1

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 80
Alternative name(s):
Cytokeratin-80
Short name:
CK-80
Keratin-80
Short name:
K80
Type-II keratin Kb20
Gene namesi
Name:Krt80
Synonyms:Kb20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1921377 Krt80

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148971 – 452Keratin, type II cytoskeletal 80Add BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ0VBK2
PeptideAtlasiQ0VBK2
PRIDEiQ0VBK2

PTM databases

iPTMnetiQ0VBK2
PhosphoSitePlusiQ0VBK2

Expressioni

Gene expression databases

BgeeiENSMUSG00000037185 Expressed in 25 organ(s), highest expression level in zone of skin
CleanExiMM_KRT80
ExpressionAtlasiQ0VBK2 baseline and differential

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

IntActiQ0VBK2, 1 interactor
MINTiQ0VBK2

Structurei

3D structure databases

ProteinModelPortaliQ0VBK2
SMRiQ0VBK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 394IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 82HeadAdd BLAST82
Regioni82 – 118Coil 1AAdd BLAST37
Regioni119 – 135Linker 1Add BLAST17
Regioni136 – 227Coil 1BAdd BLAST92
Regioni228 – 251Linker 12Add BLAST24
Regioni252 – 390Coil 2Add BLAST139
Regioni391 – 452TailAdd BLAST62

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGH5 Eukaryota
ENOG411183I LUCA
GeneTreeiENSGT00910000144006
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ0VBK2
KOiK07605
OMAiMACRSCV
OrthoDBiEOG091G0AOP
PhylomeDBiQ0VBK2
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q0VBK2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYRSCVVGF SSLSGCEMTP AGSPQPGTSG WGSCGLPGPG FSSRSLTSCR
60 70 80 90 100
PAGTIPKVTV NPSLLVPLDL KVDPAVQQQK NQEKEEMKAL NDKFASLIGK
110 120 130 140 150
VQALEQRNQL LETRWSFLQG QGSATFDLSH HYETFQGRLQ EELRKVSQER
160 170 180 190 200
GQLEANLLQV LEKVEEFRVR YEDEISKRTD LEFTFVQLKK DLDAECLRRT
210 220 230 240 250
ELETKLKGLQ GFLELMRTVY EQELKDLTAQ VKDVSVTVGL DSRCHIDLSG
260 270 280 290 300
IVEEVKAQYD AIAARSLEEA EAYSRSQLEE RAARSAEFGN SLQSSRCEIA
310 320 330 340 350
DLNVRIQKLR SQIVSVKSHC LKLEENIKVA EEQGELAFQD AKDKMAQLEN
360 370 380 390 400
ALQKAKQDMA RQLREYQDLM NTKLALDIEI ATYHKLMEGE ESRMDLPSAT
410 420 430 440 450
VVSTVKSGCR TTASKSGLTK TSSRKKKNRR GPVIKITEMS EKYLSQESEA

SE
Length:452
Mass (Da):50,660
Last modified:September 5, 2006 - v1
Checksum:iC40B0C724A43720C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TBQ1Q3TBQ1_MOUSE
Keratin, type II cytoskeletal 80
Krt80
221Annotation score:
A0A2R8VHR6A0A2R8VHR6_MOUSE
Keratin, type II cytoskeletal 80
Krt80 mCG_16840
399Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119366 mRNA Translation: AAI19367.1
BC120601 mRNA Translation: AAI20602.1
CCDSiCCDS37216.1
RefSeqiNP_083046.2, NM_028770.2
UniGeneiMm.440055

Genome annotation databases

EnsembliENSMUST00000077196; ENSMUSP00000076437; ENSMUSG00000037185
GeneIDi74127
KEGGimmu:74127
UCSCiuc007xta.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119366 mRNA Translation: AAI19367.1
BC120601 mRNA Translation: AAI20602.1
CCDSiCCDS37216.1
RefSeqiNP_083046.2, NM_028770.2
UniGeneiMm.440055

3D structure databases

ProteinModelPortaliQ0VBK2
SMRiQ0VBK2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ0VBK2, 1 interactor
MINTiQ0VBK2

PTM databases

iPTMnetiQ0VBK2
PhosphoSitePlusiQ0VBK2

Proteomic databases

PaxDbiQ0VBK2
PeptideAtlasiQ0VBK2
PRIDEiQ0VBK2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077196; ENSMUSP00000076437; ENSMUSG00000037185
GeneIDi74127
KEGGimmu:74127
UCSCiuc007xta.1 mouse

Organism-specific databases

CTDi144501
MGIiMGI:1921377 Krt80

Phylogenomic databases

eggNOGiENOG410IGH5 Eukaryota
ENOG411183I LUCA
GeneTreeiENSGT00910000144006
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ0VBK2
KOiK07605
OMAiMACRSCV
OrthoDBiEOG091G0AOP
PhylomeDBiQ0VBK2
TreeFamiTF317854

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Miscellaneous databases

PROiPR:Q0VBK2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037185 Expressed in 25 organ(s), highest expression level in zone of skin
CleanExiMM_KRT80
ExpressionAtlasiQ0VBK2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK2C80_MOUSE
AccessioniPrimary (citable) accession number: Q0VBK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: October 10, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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