Mcm10

Functionⁱ

Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (By similarity).By similarity

GO - Molecular functionⁱ

DNA replication origin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
double-stranded DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 24115439
identical protein binding Source: MGI
metal ion binding Source: UniProtKB-KW
single-stranded DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 21693137
cellular response to DNA damage stimulus Source: UniProtKB
DNA replication initiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	DNA damage, DNA replication
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-176187 Activation of ATR in response to replication stress R-MMU-68962 Activation of the pre-replicative complex

Reactomeⁱ

R-MMU-176187 Activation of ATR in response to replication stress
R-MMU-68962 Activation of the pre-replicative complex

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein MCM10 homolog
Gene namesⁱ	Name:Mcm10
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:1917274 Mcm10

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000278321	1 – 885	Protein MCM10 homologAdd BLAST		885

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	85	PhosphothreonineCombined sources	1
Cross-linkⁱ	639	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	656	PhosphoserineCombined sources	1
Cross-linkⁱ	772	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	773	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q0VBD2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q0VBD2
PaxDbⁱ	Q0VBD2
PeptideAtlas More...PeptideAtlasⁱ	Q0VBD2
PRIDEⁱ	Q0VBD2

PTM databases

iPTMnetⁱ	Q0VBD2
PhosphoSitePlusⁱ	Q0VBD2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000026669 Expressed in 192 organ(s), highest expression level in secondary oocyte
Genevisibleⁱ	Q0VBD2 MM

Interactionⁱ

Subunit structureⁱ

Self-associates (By similarity). Interacts with ORC2. May interact with MCM2 and MCM6. Interacts with the DNA polymerase alpha subunit POLA1. Interacts with RECQL4; this interaction regulates RECQL4 unwinding activity. Interacts with WDHD1 (By similarity).By similarity

GO - Molecular functionⁱ

enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 24115439
identical protein binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	213824, 2 interactors
STRINGⁱ	10090.ENSMUSP00000027980

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q0VBD2
SMRⁱ	Q0VBD2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 153	N-terminal domainBy similarityAdd BLAST	153
Regionⁱ	251 – 405	OB-fold domainBy similarityAdd BLAST	155
Regionⁱ	406 – 431	Zinc finger-like 1Add BLAST	26
Regionⁱ	793 – 812	Zinc finger-like 2By similarityAdd BLAST	20
Regionⁱ	826 – 846	Zinc finger-like 3By similarityAdd BLAST	21

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	101 – 139	Sequence analysisAdd BLAST		39

Domainⁱ

Each zinc finger-like domain binds a zinc ion and is involved in both ssDNA and dsDNA binding, as is the OB-fold domain.By similarity

The N-terminal domain mediates homodimerization.By similarity

Sequence similaritiesⁱ

Belongs to the MCM10 family.Curated

Keywords - Domainⁱ

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3056 Eukaryota ENOG41100ZT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007134
HOGENOMⁱ	HOG000082481
HOVERGENⁱ	HBG055312
InParanoidⁱ	Q0VBD2
KEGG Orthology (KO) More...KOⁱ	K10736
OMAⁱ	VACLSID
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G053R
PhylomeDBⁱ	Q0VBD2
TreeFamⁱ	TF313330

Family and domain databases

InterProⁱ	View protein in InterPro IPR015411 Rep_factor_Mcm10_C IPR015408 Znf_Mcm10/DnaG
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09332 Mcm10, 1 hit PF09329 zf-primase, 1 hit
SMARTⁱ	View protein in SMART SM01280 Mcm10, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q0VBD2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDVEEDDLCL LTSLLEENEA VLPCSSEKDK SLSLGDGDPD EFDELFDADG 
        60         70         80         90        100
DGESYTEEAG SGEEGKTGNQ EERLATLFGD VEDLTDDEVA TSKVGNSGPP 
       110        120        130        140        150
PAPSQEKTSE ELQDELKKLQ EQMKSLQEQL KAASIKQPPG TAPLQEPPDS 
       160        170        180        190        200
SLQPLLKEKR IRRIQESACF SAELDVPTLP KAKRVARKPK TPAESSSRMR 
       210        220        230        240        250
TPAQPLQVSS SFLEPNHSSS SRSSTPSPQA VPGNKCSRTI RNQNTVSPGN 
       260        270        280        290        300
SGDRPQQVSQ VSVEAFSGLR LRRPRVSSTE MSRKMAGRKL IRLPQIKEKM 
       310        320        330        340        350
ATENLEETDW VTFGVILRKV TPQSATSGQT FSIWKLNDLH DLTQCVSLFL 
       360        370        380        390        400
FGDVHKDLWK TEQGTVIGLL NANPMKPKDG LKEVCLSIDH PQKVLIMGEA 
       410        420        430        440        450
MDLGACKAKK KNGEPCTQTV NLHDCEYCQY HIQAQYKKLS AKRTDLQSTF 
       460        470        480        490        500
SGGRIPKKFR KGTSLKERLC QDGFYYGGVS SESFAASRAA AIAPKKKVQT 
       510        520        530        540        550
TLTNLVVRGT NSIIQETKQK LGIPQKSLSC SEEFRELMAL PTFGARNLQK 
       560        570        580        590        600
HLARAKASGS SKPAIQSISA SALLKQQKQQ MLEMRKRRSE DIQKRFLQSS 
       610        620        630        640        650
SEVQSPAVPS SSRQAAAQSP RTGAEFPRLE GTATPRMPKL GRGISEGDDV 
       660        670        680        690        700
LFFDDSPPPR PKLSAAAEAK KLAAIAKLRA KGQILTKVDP NNTVRKQMDG 
       710        720        730        740        750
RAMLGVKERV ENSNTVSPEE ELEPARKKRR EQLAYLESEE FQKILKAKSK 
       760        770        780        790        800
HTDILKEAEA ELQKSYFEPL VKKEQMEEKM RATREVKCRV VTCRTCTYTH 
       810        820        830        840        850
FKPLETCVSE QHNLHWHDGV KRFFKCPCGN RTISLDKLPN KHCRNCGLYK 
       860        870        880 
WERDGMLKEK TGPKIGGETL LPRGEEHAKF LNSLK

Length:885

Mass (Da):98,406

Last modified:September 5, 2006 - v1

Checksum:ⁱCF2F91AC0A8A18B1

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	50	G → R in AAH94576 (PubMed:15489334).Curated	1
Sequence conflictⁱ	673	A → V in BAC27135 (PubMed:16141072).Curated	1
Sequence conflictⁱ	873	R → I in AAH94576 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK030780 mRNA Translation: BAC27135.1 AK041406 mRNA Translation: BAC30933.1 AL928662 Genomic DNA No translation available. BC094576 mRNA Translation: AAH94576.1 BC120689 mRNA Translation: AAI20690.1 BC120687 mRNA Translation: AAI20688.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15662.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001292188.1, NM_001305259.1 NP_081566.2, NM_027290.3
UniGeneⁱ	Mm.23828 Mm.447935

Genome annotation databases

Ensemblⁱ	ENSMUST00000027980; ENSMUSP00000027980; ENSMUSG00000026669 ENSMUST00000102985; ENSMUSP00000100050; ENSMUSG00000026669
GeneIDⁱ	70024
KEGGⁱ	mmu:70024
UCSC genome browser More...UCSCⁱ	uc008ifh.2 mouse

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q0VBD2	Protein MCM10 homolog		HUMAN		875	UniRef50_Q7L590
Protein MCM10 homolog		XENTR		845
Protein MCM10 homolog	)	XENLA		860
Uncharacterized protein		CERAT		877
Uncharacterized protein		MACFA		877
+344

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK030780 mRNA Translation: BAC27135.1 AK041406 mRNA Translation: BAC30933.1 AL928662 Genomic DNA No translation available. BC094576 mRNA Translation: AAH94576.1 BC120689 mRNA Translation: AAI20690.1 BC120687 mRNA Translation: AAI20688.1
CCDSⁱ	CCDS15662.1
RefSeqⁱ	NP_001292188.1, NM_001305259.1 NP_081566.2, NM_027290.3
UniGeneⁱ	Mm.23828 Mm.447935

3D structure databases

ProteinModelPortalⁱ	Q0VBD2
SMRⁱ	Q0VBD2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	213824, 2 interactors
STRINGⁱ	10090.ENSMUSP00000027980

PTM databases

iPTMnetⁱ	Q0VBD2
PhosphoSitePlusⁱ	Q0VBD2

Proteomic databases

EPDⁱ	Q0VBD2
MaxQBⁱ	Q0VBD2
PaxDbⁱ	Q0VBD2
PeptideAtlasⁱ	Q0VBD2
PRIDEⁱ	Q0VBD2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000027980; ENSMUSP00000027980; ENSMUSG00000026669 ENSMUST00000102985; ENSMUSP00000100050; ENSMUSG00000026669
GeneIDⁱ	70024
KEGGⁱ	mmu:70024
UCSCⁱ	uc008ifh.2 mouse

Organism-specific databases

CTDⁱ	55388
MGIⁱ	MGI:1917274 Mcm10

Phylogenomic databases

eggNOGⁱ	KOG3056 Eukaryota ENOG41100ZT LUCA
GeneTreeⁱ	ENSGT00390000007134
HOGENOMⁱ	HOG000082481
HOVERGENⁱ	HBG055312
InParanoidⁱ	Q0VBD2
KOⁱ	K10736
OMAⁱ	VACLSID
OrthoDBⁱ	EOG091G053R
PhylomeDBⁱ	Q0VBD2
TreeFamⁱ	TF313330

Enzyme and pathway databases

Reactomeⁱ	R-MMU-176187 Activation of ATR in response to replication stress R-MMU-68962 Activation of the pre-replicative complex

Reactomeⁱ

R-MMU-176187 Activation of ATR in response to replication stress
R-MMU-68962 Activation of the pre-replicative complex

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q0VBD2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000026669 Expressed in 192 organ(s), highest expression level in secondary oocyte
Genevisibleⁱ	Q0VBD2 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR015411 Rep_factor_Mcm10_C IPR015408 Znf_Mcm10/DnaG
Pfamⁱ	View protein in Pfam PF09332 Mcm10, 1 hit PF09329 zf-primase, 1 hit
SMARTⁱ	View protein in SMART SM01280 Mcm10, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MCM10_MOUSE
Accessionⁱ	Q0VBD2Primary (citable) accession number: Q0VBD2 Secondary accession number(s): Q505F3, Q8BMJ1, Q8BYA7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
	Last sequence update:	September 5, 2006
	Last modified:	November 7, 2018
	This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q0VBD2 (MCM10_MOUSE)

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Protein MCM10 homolog

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ