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Entry version 90 (07 Apr 2021)
Sequence version 1 (05 Sep 2006)
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Protein
Submitted name:

Muc6 protein

Gene

Muc6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Muc6 proteinImported
Submitted name:
Mucin-6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Muc6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2663233, Muc6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501509699623 – 1437Sequence analysisAdd BLAST1415

Proteomic databases

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
336426

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000048191, Expressed in stomach and 47 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 247VWFDInterPro annotationAdd BLAST204
Domaini397 – 609VWFDInterPro annotationAdd BLAST213
Domaini868 – 1076VWFDInterPro annotationAdd BLAST209

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1205 – 1323DisorderedSequence analysisAdd BLAST119

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1205 – 1234PolarSequence analysisAdd BLAST30
Compositional biasi1250 – 1278PolarSequence analysisAdd BLAST29
Compositional biasi1279 – 1293Pro-richSequence analysisAdd BLAST15
Compositional biasi1294 – 1323PolarSequence analysisAdd BLAST30

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

RepeatARBA annotation, SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161708

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000076_2_1_1

Database of Orthologous Groups

More...
OrthoDBi
12226at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030124, MUC6
IPR036084, Ser_inhib-like_sf
IPR002919, TIL_dom
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D

The PANTHER Classification System

More...
PANTHERi
PTHR11339:SF264, PTHR11339:SF264, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08742, C8, 3 hits
PF01826, TIL, 3 hits
PF00094, VWD, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832, C8, 3 hits
SM00215, VWC_out, 2 hits
SM00216, VWD, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57567, SSF57567, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51233, VWFD, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q0VAV1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRVRQLLLL LLFRGPLIDA GAWTGDVTDS DTEDNLQSSP EKGWCSTWGA
60 70 80 90 100
GHFSTFDGHE YNFQGMCNYI FTATCGDDVP ATFSIQLRRD MEGNISRIIM
110 120 130 140 150
ELGASVVTVN KETISVRDIG VVSLPYTSNG LQITPYGQSV QLVAKQLELE
160 170 180 190 200
LVITWGPDAH LTVQVETKYM GKLCGLCGNF DGKIDNEFLS EDGKLLEAHK
210 220 230 240 250
YATLQKLDDP NEICAHEAIP STIILKTRYA QICNQLLTLV SPGCDVPKET
260 270 280 290 300
LMLSCQADMA ACARPGQPNC SCATLSEYSR RCSMTGQPVR NWRTPALCPM
310 320 330 340 350
SQCPANQVYQ ECGEVCIKTC SNPQHSCSSP CTFGCFCPHG TLLDDISGNQ
360 370 380 390 400
SCVPVNQCPC MLNGMVYGPG EITKTACQTC QCTMGRWTCT KQPCPGHCSL
410 420 430 440 450
EGGSFVTTFD ARPYRFHGTC TYTLLQSPQL PNEGTLMAVY DKSGYSHSET
460 470 480 490 500
SLVAIMYLSK KDKIVISEDE VITNNGDTKL LPYKTHNITI FRQTSTHLQM
510 520 530 540 550
ATTFGLELVF QMQPVFQVYI TVGPQFKGQT RGLCGNFNGD TTDDFTTSMG
560 570 580 590 600
IDEGTASLFV DSWRAGNCPA ALEREMDPCS MSQLNKVCAE THCSMLLKKG
610 620 630 640 650
SVFEKCHSVV NPQPFYKRCV YQACNYEETF PHICSALGAY AHACSARGIL
660 670 680 690 700
LWGWRNSVDN CTVPCTGNRT FSYDSQACDR TCLSLSDRET ECHVSPVPVD
710 720 730 740 750
GCNCPEGTYL NHKAECVHKA QCPCLLDDYK FVQADQSTMI NGVICHCING
760 770 780 790 800
RLSCPRQAEM FFASCPEPKT FQSCSQSSED KFGAACAPTC QMLATGIDCV
810 820 830 840 850
PTKCESGCVC PKGLYENSDG QCVPAEECPC DYAGVSYPGG FELHTDCKTC
860 870 880 890 900
TCSQGRWTCQ LSTQCPSTCV LYGEGHIITF DGQRFVFDGD CEYMLATDDC
910 920 930 940 950
GANSSQPTFK VLTENVICGK SGVTCSRAIK ISLGGLFITM ADSNYTVSGE
960 970 980 990 1000
EPLVHLKVKP SPLNLVLDID IPGRLNLTLV WNKHMSVSIK IRRATQDALC
1010 1020 1030 1040 1050
GLCGNANGNM KDDFETRSKY VASNELEFVN SWKESPLCGD ASYAVDPCSL
1060 1070 1080 1090 1100
NTFRRSWAER KCNIINSQTF AACHSKVYHL PYYEACVRDA CGCDTGGDCE
1110 1120 1130 1140 1150
CLCDAVAAYA KACLDKGVCV DWRTPDFCPI YCDFYNTHTL VGENEYQYAQ
1160 1170 1180 1190 1200
ESNCTWHYQP CLCPGSLGSF PDTNTEGCYN CSQNEYFDHS EGTCVPCAPP
1210 1220 1230 1240 1250
TTTLPPTTTG SQPTTETTIS TEFHSSTSAN TPVAPSYLPG LPTPPPSAPS
1260 1270 1280 1290 1300
STEELTVWTT PKESTVSSGE YPQTTMAATP PTSPWPPTSI PKSTPTELPV
1310 1320 1330 1340 1350
TQATSKPTAS SLSSSTKTTA ELTESTTVTL LTLMPGMSTS QGKTSASYTT
1360 1370 1380 1390 1400
QHQSTSFHLT TISKWPTNGP QHFSHWKLLT FYPSIILQSR LLGLLATLAS
1410 1420 1430
WDLQLTGGRA PDYLPGLCGQ CDSNSLPGFL RLLCQFQ
Length:1,437
Mass (Da):156,889
Last modified:September 5, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4AFAC5374DE86E15
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80T03MUC6_MOUSE
Mucin-6
Muc6
2,850Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WR59A0A087WR59_MOUSE
Mucin-6
Muc6
2,918Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WIM6F8WIM6_MOUSE
Mucin-6
Muc6
2,853Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC102524 Genomic DNA No translation available.
BC120907 mRNA Translation: AAI20908.1

NCBI Reference Sequences

More...
RefSeqi
NP_001316930.1, NM_001330001.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000189314; ENSMUSP00000140388; ENSMUSG00000048191

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
353328

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:353328

UCSC genome browser

More...
UCSCi
uc009klv.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102524 Genomic DNA No translation available.
BC120907 mRNA Translation: AAI20908.1
RefSeqiNP_001316930.1, NM_001330001.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

ProteomicsDBi336426

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22789, 342 antibodies

The DNASU plasmid repository

More...
DNASUi
353328

Genome annotation databases

EnsembliENSMUST00000189314; ENSMUSP00000140388; ENSMUSG00000048191
GeneIDi353328
KEGGimmu:353328
UCSCiuc009klv.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4588
MGIiMGI:2663233, Muc6

Phylogenomic databases

GeneTreeiENSGT00940000161708
HOGENOMiCLU_000076_2_1_1
OrthoDBi12226at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
353328, 1 hit in 9 CRISPR screens

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000048191, Expressed in stomach and 47 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR030124, MUC6
IPR036084, Ser_inhib-like_sf
IPR002919, TIL_dom
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D
PANTHERiPTHR11339:SF264, PTHR11339:SF264, 1 hit
PfamiView protein in Pfam
PF08742, C8, 3 hits
PF01826, TIL, 3 hits
PF00094, VWD, 3 hits
SMARTiView protein in SMART
SM00832, C8, 3 hits
SM00215, VWC_out, 2 hits
SM00216, VWD, 3 hits
SUPFAMiSSF57567, SSF57567, 3 hits
PROSITEiView protein in PROSITE
PS51233, VWFD, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ0VAV1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0VAV1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: April 7, 2021
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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