Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Small cell adhesion glycoprotein

Gene

SMAGP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandSialic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Small cell adhesion glycoprotein
Alternative name(s):
Small transmembrane and glycosylated protein
Gene namesi
Name:SMAGP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000170545.16
HGNCiHGNC:26918 SMAGP
neXtProtiNX_Q0VAQ4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36ExtracellularSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini58 – 97CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57228
OpenTargetsiENSG00000170545
PharmGKBiPA165513352

Polymorphism and mutation databases

BioMutaiSMAGP
DMDMi121940462

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003287951 – 97Small cell adhesion glycoproteinAdd BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi3O-linked (GalNAc...) serineSequence analysis1
Glycosylationi6O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi7O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi9O-linked (GalNAc...) serineSequence analysis1
Glycosylationi16O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi17O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi23O-linked (GalNAc...) threonineSequence analysis1

Post-translational modificationi

O-glycosylated. The O-glycan is modified with sialic acid residues.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ0VAQ4
MaxQBiQ0VAQ4
PaxDbiQ0VAQ4
PeptideAtlasiQ0VAQ4
PRIDEiQ0VAQ4
ProteomicsDBi58808
TopDownProteomicsiQ0VAQ4

PTM databases

iPTMnetiQ0VAQ4
PhosphoSitePlusiQ0VAQ4

Expressioni

Tissue specificityi

Detected in breast, endometrium, colon and biliary tract. Detected in polarized epithelial structures characterized by cell-cell adhesion (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000170545 Expressed in 170 organ(s), highest expression level in esophagus mucosa
ExpressionAtlasiQ0VAQ4 baseline and differential
GenevisibleiQ0VAQ4 HS

Organism-specific databases

HPAiHPA039711

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SGTAO437653EBI-10226799,EBI-347996

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121462, 3 interactors
IntActiQ0VAQ4, 33 interactors

Structurei

3D structure databases

ProteinModelPortaliQ0VAQ4
SMRiQ0VAQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SMAGP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3FG Eukaryota
ENOG410ZCM8 LUCA
GeneTreeiENSGT00390000010077
HOGENOMiHOG000154341
HOVERGENiHBG100579
InParanoidiQ0VAQ4
OMAiDREKEEY
OrthoDBiEOG091G16WO
PhylomeDBiQ0VAQ4
TreeFamiTF337016

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q0VAQ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSLLTTPSP REELMTTPIL QPTEALSPED GASTALIAVV ITVVFLTLLS
60 70 80 90
VVILIFFYLY KNKGSYVTYE PTEGEPSAIV QMESDLAKGS EKEEYFI
Length:97
Mass (Da):10,679
Last modified:September 5, 2006 - v1
Checksum:i90BC88F950B94904
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R466S4R466_HUMAN
Small cell adhesion glycoprotein
SMAGP
83Annotation score:
S4R3E1S4R3E1_HUMAN
Small cell adhesion glycoprotein
SMAGP
50Annotation score:
S4R405S4R405_HUMAN
Small cell adhesion glycoprotein
SMAGP
42Annotation score:
A0A0A0MRX0A0A0A0MRX0_HUMAN
Small cell adhesion glycoprotein
SMAGP
37Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC046135 Genomic DNA No translation available.
AC139768 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW58184.1
BC008712 mRNA Translation: AAH08712.2
BC120965 mRNA Translation: AAI20966.1
BC120966 mRNA Translation: AAI20967.1
CCDSiCCDS44889.1
RefSeqiNP_001026798.1, NM_001031628.1
NP_001029045.1, NM_001033873.1
UniGeneiHs.652389

Genome annotation databases

EnsembliENST00000398453; ENSP00000381471; ENSG00000170545
ENST00000603798; ENSP00000475068; ENSG00000170545
ENST00000603864; ENSP00000474892; ENSG00000170545
GeneIDi57228
KEGGihsa:57228
UCSCiuc001ryd.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC046135 Genomic DNA No translation available.
AC139768 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW58184.1
BC008712 mRNA Translation: AAH08712.2
BC120965 mRNA Translation: AAI20966.1
BC120966 mRNA Translation: AAI20967.1
CCDSiCCDS44889.1
RefSeqiNP_001026798.1, NM_001031628.1
NP_001029045.1, NM_001033873.1
UniGeneiHs.652389

3D structure databases

ProteinModelPortaliQ0VAQ4
SMRiQ0VAQ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121462, 3 interactors
IntActiQ0VAQ4, 33 interactors

PTM databases

iPTMnetiQ0VAQ4
PhosphoSitePlusiQ0VAQ4

Polymorphism and mutation databases

BioMutaiSMAGP
DMDMi121940462

Proteomic databases

EPDiQ0VAQ4
MaxQBiQ0VAQ4
PaxDbiQ0VAQ4
PeptideAtlasiQ0VAQ4
PRIDEiQ0VAQ4
ProteomicsDBi58808
TopDownProteomicsiQ0VAQ4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398453; ENSP00000381471; ENSG00000170545
ENST00000603798; ENSP00000475068; ENSG00000170545
ENST00000603864; ENSP00000474892; ENSG00000170545
GeneIDi57228
KEGGihsa:57228
UCSCiuc001ryd.2 human

Organism-specific databases

CTDi57228
DisGeNETi57228
EuPathDBiHostDB:ENSG00000170545.16
GeneCardsiSMAGP
HGNCiHGNC:26918 SMAGP
HPAiHPA039711
neXtProtiNX_Q0VAQ4
OpenTargetsiENSG00000170545
PharmGKBiPA165513352
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3FG Eukaryota
ENOG410ZCM8 LUCA
GeneTreeiENSGT00390000010077
HOGENOMiHOG000154341
HOVERGENiHBG100579
InParanoidiQ0VAQ4
OMAiDREKEEY
OrthoDBiEOG091G16WO
PhylomeDBiQ0VAQ4
TreeFamiTF337016

Miscellaneous databases

ChiTaRSiSMAGP human
GenomeRNAii57228
PROiPR:Q0VAQ4

Gene expression databases

BgeeiENSG00000170545 Expressed in 170 organ(s), highest expression level in esophagus mucosa
ExpressionAtlasiQ0VAQ4 baseline and differential
GenevisibleiQ0VAQ4 HS

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiSMAGP_HUMAN
AccessioniPrimary (citable) accession number: Q0VAQ4
Secondary accession number(s): A6NIL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: September 5, 2006
Last modified: September 12, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again