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Protein

Syncollin

Gene

SYCN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processExocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Syncollin
Alternative name(s):
Insulin synthesis-associated protein 1
Gene namesi
Name:SYCN
Synonyms:INSSA1, SYL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000179751.6
HGNCiHGNC:18442 SYCN
neXtProtiNX_Q0VAF6

Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179751
PharmGKBiPA142670850

Polymorphism and mutation databases

BioMutaiSYCN
DMDMi121948659

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000029527622 – 134SyncollinBy similarityAdd BLAST113

Post-translational modificationi

Contains intrachain disulfide bonds.By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ0VAF6
PeptideAtlasiQ0VAF6
PRIDEiQ0VAF6
ProteomicsDBi58794
TopDownProteomicsiQ0VAF6

PTM databases

iPTMnetiQ0VAF6
PhosphoSitePlusiQ0VAF6

Expressioni

Gene expression databases

BgeeiENSG00000179751
CleanExiHS_SYCN
GenevisibleiQ0VAF6 HS

Organism-specific databases

HPAiHPA047654

Interactioni

Subunit structurei

Monomer and homooligomer; most probably hexameric. Interacts with GP2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi131205, 4 interactors
STRINGi9606.ENSP00000325564

Structurei

3D structure databases

ProteinModelPortaliQ0VAF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0PE Eukaryota
ENOG4111ZQA LUCA
GeneTreeiENSGT00390000014835
HOGENOMiHOG000154465
HOVERGENiHBG100284
InParanoidiQ0VAF6
KOiK19935
OMAiISALYCR
OrthoDBiEOG091G0UES
PhylomeDBiQ0VAF6
TreeFamiTF338021

Family and domain databases

InterProiView protein in InterPro
IPR028137 Syncollin
PANTHERiPTHR17503 PTHR17503, 1 hit
PfamiView protein in Pfam
PF15138 Syncollin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VAF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPLRPLLLA LALASVPCAQ GACPASADLK HSDGTRTCAK LYDKSDPYYE
60 70 80 90 100
NCCGGAELSL ESGADLPYLP SNWANTASSL VVAPRCELTV WSRQGKAGKT
110 120 130
HKFSAGTYPR LEEYRRGILG DWSNAISALY CRCS
Length:134
Mass (Da):14,405
Last modified:September 5, 2006 - v1
Checksum:i1928D95BA3EC4274
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033284111L → M. Corresponds to variant dbSNP:rs2082416Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121075 mRNA Translation: AAI21076.1
BC121076 mRNA Translation: AAI21077.1
CCDSiCCDS46070.1
RefSeqiNP_001073937.1, NM_001080468.3
UniGeneiHs.124123

Genome annotation databases

EnsembliENST00000318438; ENSP00000325564; ENSG00000179751
GeneIDi342898
KEGGihsa:342898
UCSCiuc002okr.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSYCN_HUMAN
AccessioniPrimary (citable) accession number: Q0VAF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: September 5, 2006
Last modified: June 20, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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