UniProtKB - Q0VAB0 (Q0VAB0_HUMAN)
Protein
Prostanoid TP receptor
Gene
TBXA2R
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- thromboxane receptor activity Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorARBA annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Prostanoid TP receptorARBA annotationAlternative name(s): Thromboxane A2 receptorARBA annotation |
Gene namesi | Name:TBXA2RImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 29 – 51 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 63 – 87 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 107 – 127 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembranePTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotation, PhosphoproteinARBA annotationInteractioni
Binary interactionsi
Hide detailsQ0VAB0
Protein-protein interaction databases
IntActi | Q0VAB0, 13 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 137 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 97 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 166 – 259 | DisorderedSequence analysisAdd BLAST | 94 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 175 – 200 | Pro-richSequence analysisAdd BLAST | 26 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
OrthoDBi | 972015at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR008365, Prostanoid_rcpt IPR001105, Thbox_rcpt |
PANTHERi | PTHR11866, PTHR11866, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01788, PROSTANOIDR PR00429, THROMBOXANER |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q0VAB0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWPNGSSLGP CFRPTNITLE ERRLIASPWF AASFCVVGLA SNLLALSVLA
60 70 80 90 100
GARQGGSHTR SSFLTFLCGL VLTDFLGLLV TGTIVVSQHA ALFEWHAVDP
110 120 130 140 150
GCRLCRFMGV VMIFFGLSPL LLGAAMASER YLGLHCPDSA AKPACHEPRR
160 170 180 190 200
AAVPHHGEGA AHLLARGHLE PDPGPLGVYP VPPRRAPASP ASPQHPAQVA
210 220 230 240 250
VPPAPAHAAL RAAVGSGQSA PPAPFRGALG PSDSPSACSE DSGAGGAGWT
VGISSRVLG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC121148 mRNA Translation: AAI21149.1 |
RefSeqi | NP_001051.1, NM_001060.5 NP_963998.2, NM_201636.2 |
Genome annotation databases
GeneIDi | 6915 |
KEGGi | hsa:6915 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC121148 mRNA Translation: AAI21149.1 |
RefSeqi | NP_001051.1, NM_001060.5 NP_963998.2, NM_201636.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q0VAB0, 13 interactors |
Genome annotation databases
GeneIDi | 6915 |
KEGGi | hsa:6915 |
Organism-specific databases
CTDi | 6915 |
PharmGKBi | PA348 |
Phylogenomic databases
OrthoDBi | 972015at2759 |
Miscellaneous databases
BioGRID-ORCSi | 6915, 6 hits in 842 CRISPR screens |
ChiTaRSi | TBXA2R, human |
GenomeRNAii | 6915 |
Gene expression databases
Genevisiblei | Q0VAB0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR008365, Prostanoid_rcpt IPR001105, Thbox_rcpt |
PANTHERi | PTHR11866, PTHR11866, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01788, PROSTANOIDR PR00429, THROMBOXANER |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q0VAB0_HUMAN | |
Accessioni | Q0VAB0Primary (citable) accession number: Q0VAB0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 5, 2006 |
Last sequence update: | September 5, 2006 | |
Last modified: | December 2, 2020 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |