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Entry version 117 (29 Sep 2021)
Sequence version 2 (05 Oct 2010)
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Protein

Leucine-rich repeat-containing protein 74A

Gene

LRRC74A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

It is uncertain whether Met-1 or Met-27 is the initiator.Curated

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q0VAA2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 74AImported
Alternative name(s):
Leucine-rich repeat-containing protein 74Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC74AImported
Synonyms:C14orf166BImported, LRRC74Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23346, LRRC74A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q0VAA2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000100565

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000100565

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134862662

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q0VAA2, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRC74A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153427

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003061721 – 488Leucine-rich repeat-containing protein 74AAdd BLAST488

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q0VAA2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q0VAA2

PeptideAtlas

More...
PeptideAtlasi
Q0VAA2

PRoteomics IDEntifications database

More...
PRIDEi
Q0VAA2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58787 [Q0VAA2-1]
58788 [Q0VAA2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q0VAA2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q0VAA2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100565, Expressed in right testis and 96 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q0VAA2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q0VAA2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000100565, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126917, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q0VAA2, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377369

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q0VAA2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati134 – 155LRR 1Add BLAST22
Repeati162 – 182LRR 2Add BLAST21
Repeati191 – 212LRR 3Add BLAST22
Repeati219 – 239LRR 4Add BLAST21
Repeati247 – 268LRR 5Add BLAST22
Repeati275 – 296LRR 6Add BLAST22
Repeati303 – 324LRR 7Add BLAST22
Repeati331 – 351LRR 8Add BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4308, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154297

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017147_3_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q0VAA2

Identification of Orthologs from Complete Genome Data

More...
OMAi
ANDIPPY

Database of Orthologous Groups

More...
OrthoDBi
1463268at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q0VAA2

TreeFam database of animal gene trees

More...
TreeFami
TF329403

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13516, LRR_6, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q0VAA2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHIQFPSKPT LPRACWEGRI TAGSPGMPPD EIEIEPVRQS SDKMLYCEAE
60 70 80 90 100
SPPTVEKVKP ARENSETDLE IEDDEKFFTT GQKELYLEAC KLMGVVPVSY
110 120 130 140 150
FIRNMEESYV NLNHHGLGPR GTKAIAIALV SNMAVTKLEL EDNCIMEEGV
160 170 180 190 200
LSLVEMLQEN YYLQEMNISN NHLGLEGARI ISDFFERNSS SIWSLELSGN
210 220 230 240 250
DFKEDSAALL CQALSTNYQI KKLDLSHNQF SDVGGEHLGQ MLAINVGLTS
260 270 280 290 300
LDLSWNNFHT RGAVALCNGL RGNVTLTKLD LSMNGFGNEV ALALGEVLRL
310 320 330 340 350
NRCLVYLDIG GNDIGNEGAS KISKGLESNE SLRVLKLFLN PINMDGAILL
360 370 380 390 400
ILAIKRNPKS RMEELDISNV LVSEQFMKTL DGVYAVHPQL DVVFKAVQGL
410 420 430 440 450
SPKKTIFLLT NPMKLIQSYA DQHKITIVDF FKSLNPTGTM KMSVDEFQKV
460 470 480
MIEQNKVPLN QYQVREVIKK LDEKTGMVNF SFLNTMKP
Length:488
Mass (Da):54,535
Last modified:October 5, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF1D0B73BFCCCE933
GO
Isoform 2 (identifier: Q0VAA2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.
     273-311: NVTLTKLDLS...RCLVYLDIGG → KSSDSTAAWS...DWNPMKASEF
     312-488: Missing.

Show »
Length:219
Mass (Da):24,109
Checksum:i98DEBC00F2BEB4D9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V356G3V356_HUMAN
Leucine-rich repeat-containing prot...
LRRC74A
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5M6G3V5M6_HUMAN
Leucine-rich repeat-containing prot...
LRRC74A
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXD0H7BXD0_HUMAN
Leucine-rich repeat-containing prot...
LRRC74A
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD44364 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAI21160 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI21161 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence EAW81265 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0284251 – 92Missing in isoform 2. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_028426273 – 311NVTLT…LDIGG → KSSDSTAAWSTWISVAMTSA MKGPPKSAKDWNPMKASEF in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_028427312 – 488Missing in isoform 2. 1 PublicationAdd BLAST177

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK125722 mRNA Translation: BAC86259.1
AF111169 Genomic DNA Translation: AAD44364.1 Sequence problems.
CH471061 Genomic DNA Translation: EAW81265.1 Sequence problems.
BC121159 mRNA Translation: AAI21160.1 Different initiation.
BC121160 mRNA Translation: AAI21161.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9853.2 [Q0VAA2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_919263.2, NM_194287.2 [Q0VAA2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000393774; ENSP00000377369; ENSG00000100565 [Q0VAA2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
145497

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:145497

UCSC genome browser

More...
UCSCi
uc001xsx.3, human [Q0VAA2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125722 mRNA Translation: BAC86259.1
AF111169 Genomic DNA Translation: AAD44364.1 Sequence problems.
CH471061 Genomic DNA Translation: EAW81265.1 Sequence problems.
BC121159 mRNA Translation: AAI21160.1 Different initiation.
BC121160 mRNA Translation: AAI21161.1 Different initiation.
CCDSiCCDS9853.2 [Q0VAA2-1]
RefSeqiNP_919263.2, NM_194287.2 [Q0VAA2-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi126917, 4 interactors
IntActiQ0VAA2, 2 interactors
STRINGi9606.ENSP00000377369

PTM databases

iPTMnetiQ0VAA2
PhosphoSitePlusiQ0VAA2

Genetic variation databases

BioMutaiLRRC74A
DMDMi308153427

Proteomic databases

MassIVEiQ0VAA2
PaxDbiQ0VAA2
PeptideAtlasiQ0VAA2
PRIDEiQ0VAA2
ProteomicsDBi58787 [Q0VAA2-1]
58788 [Q0VAA2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25952, 26 antibodies

The DNASU plasmid repository

More...
DNASUi
145497

Genome annotation databases

EnsembliENST00000393774; ENSP00000377369; ENSG00000100565 [Q0VAA2-1]
GeneIDi145497
KEGGihsa:145497
UCSCiuc001xsx.3, human [Q0VAA2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
145497

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LRRC74A
HGNCiHGNC:23346, LRRC74A
HPAiENSG00000100565, Tissue enriched (testis)
neXtProtiNX_Q0VAA2
OpenTargetsiENSG00000100565
PharmGKBiPA134862662
VEuPathDBiHostDB:ENSG00000100565

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4308, Eukaryota
GeneTreeiENSGT00940000154297
HOGENOMiCLU_017147_3_2_1
InParanoidiQ0VAA2
OMAiANDIPPY
OrthoDBi1463268at2759
PhylomeDBiQ0VAA2
TreeFamiTF329403

Enzyme and pathway databases

PathwayCommonsiQ0VAA2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
145497, 8 hits in 1004 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LRRC74A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
145497
PharosiQ0VAA2, Tdark

Protein Ontology

More...
PROi
PR:Q0VAA2
RNActiQ0VAA2, protein

Gene expression databases

BgeeiENSG00000100565, Expressed in right testis and 96 other tissues
ExpressionAtlasiQ0VAA2, baseline and differential
GenevisibleiQ0VAA2, HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
PfamiView protein in Pfam
PF13516, LRR_6, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLR74A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0VAA2
Secondary accession number(s): Q6ZUG6, Q9Y627
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 5, 2010
Last modified: September 29, 2021
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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