UniProtKB - Q0V7X4 (FIT_ARATH)
Protein
Transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR
Gene
FIT
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Transcription factor. Essential protein involved in iron uptake responses. Regulates FRO2 at the level of mRNA accumulation and IRT1 at the level of protein accumulation. Confers enhanced iron mobilization responses at low iron supply.3 Publications
GO - Molecular functioni
- DNA-binding transcription factor activity Source: TAIR
- protein dimerization activity Source: InterPro
- sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of iron ion transport Source: TAIR
- regulation of transcription, DNA-templated Source: GO_Central
- response to iron ion Source: TAIR
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTORAlternative name(s): Basic helix-loop-helix protein 29 Short name: AtbHLH29 Short name: bHLH 29 FER-LIKE REGULATOR OF IRON UPTAKE Transcription factor EN 43 Transcription factor Fe-DEFICIENCY INDUCED TRANSCRIPTION FACTOR 1 bHLH transcription factor bHLH029 |
Gene namesi | Name:FIT Synonyms:BHLH29, EN43, FIT1, FRU Ordered Locus Names:At2g28160 ORF Names:F24D13.5 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G28160 |
TAIRi | locus:2046198, AT2G28160 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000358844 | 1 – 318 | Transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTORAdd BLAST | 318 |
Proteomic databases
PaxDbi | Q0V7X4 |
PRIDEi | Q0V7X4 |
ProteomicsDBi | 230100 |
Expressioni
Tissue specificityi
Expressed in roots and inflorescence, and to a lower extent, in leaves and stems. In roots, confined to the outer cell layers, specifically in the differentiation zone. Also detected in the endodermis and inner tissues of the central cylinder.3 Publications
Inductioni
In roots by iron deficiency. Repressed by cytokinins. Induced by cold, UV, ethylene (ACC), jasmonic acid (JA), flagellin, and salicylic acid (SA) treatments.5 Publications
Gene expression databases
ExpressionAtlasi | Q0V7X4, baseline and differential |
Genevisiblei | Q0V7X4, AT |
Interactioni
Subunit structurei
Homodimer.
CuratedBinary interactionsi
Hide detailsQ0V7X4
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 2712, 28 interactors |
IntActi | Q0V7X4, 24 interactors |
STRINGi | 3702.AT2G28160.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 127 – 176 | bHLHPROSITE-ProRule annotationAdd BLAST | 50 |
Phylogenomic databases
eggNOGi | ENOG502QSJP, Eukaryota |
HOGENOMi | CLU_864384_0_0_1 |
InParanoidi | Q0V7X4 |
OMAi | SHTFRCI |
OrthoDBi | 1155429at2759 |
PhylomeDBi | Q0V7X4 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q0V7X4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGRVNALSN INDLELHNFL VDPNFDQFIN LIRGDHQTID ENPVLDFDLG
60 70 80 90 100
PLQNSPCFID ENQFIPTPVD DLFDELPDLD SNVAESFRSF DGDSVRAGGE
110 120 130 140 150
EDEEDYNDGD DSSATTTNND GTRKTKTDRS RTLISERRRR GRMKDKLYAL
160 170 180 190 200
RSLVPNITKM DKASIVGDAV LYVQELQSQA KKLKSDIAGL EASLNSTGGY
210 220 230 240 250
QEHAPDAQKT QPFRGINPPA SKKIIQMDVI QVEEKGFYVR LVCNKGEGVA
260 270 280 290 300
PSLYKSLESL TSFQVQNSNL SSPSPDTYLL TYTLDGTCFE QSLNLPNLKL
310
WITGSLLNQG FEFIKSFT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1P8AYH9 | A0A1P8AYH9_ARATH | FER-like regulator of iron uptake | FRU ATBHLH029, ATBHLH29, ATFIT1, BHLH029, FIT1 | 311 | Annotation score: |
Sequence cautioni
The sequence AAC98450 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 55 | S → C in AAM10938 (PubMed:12679534).Curated | 1 | |
Sequence conflicti | 160 | M → V in AAM10938 (PubMed:12679534).Curated | 1 | |
Sequence conflicti | 223 | K → E in AAM10938 (PubMed:12679534).Curated | 1 | |
Sequence conflicti | 299 | K → R in AAM10938 (PubMed:12679534).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF488570 mRNA Translation: AAM10938.1 AC005851 Genomic DNA Translation: AAC98450.1 Sequence problems. CP002685 Genomic DNA Translation: AEC08086.1 BT026446 mRNA Translation: ABH04553.1 |
PIRi | E84681 |
RefSeqi | NP_850114.1, NM_179783.2 |
Genome annotation databases
EnsemblPlantsi | AT2G28160.1; AT2G28160.1; AT2G28160 |
GeneIDi | 817362 |
Gramenei | AT2G28160.1; AT2G28160.1; AT2G28160 |
KEGGi | ath:AT2G28160 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF488570 mRNA Translation: AAM10938.1 AC005851 Genomic DNA Translation: AAC98450.1 Sequence problems. CP002685 Genomic DNA Translation: AEC08086.1 BT026446 mRNA Translation: ABH04553.1 |
PIRi | E84681 |
RefSeqi | NP_850114.1, NM_179783.2 |
3D structure databases
SMRi | Q0V7X4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 2712, 28 interactors |
IntActi | Q0V7X4, 24 interactors |
STRINGi | 3702.AT2G28160.1 |
Proteomic databases
PaxDbi | Q0V7X4 |
PRIDEi | Q0V7X4 |
ProteomicsDBi | 230100 |
Genome annotation databases
EnsemblPlantsi | AT2G28160.1; AT2G28160.1; AT2G28160 |
GeneIDi | 817362 |
Gramenei | AT2G28160.1; AT2G28160.1; AT2G28160 |
KEGGi | ath:AT2G28160 |
Organism-specific databases
Araporti | AT2G28160 |
TAIRi | locus:2046198, AT2G28160 |
Phylogenomic databases
eggNOGi | ENOG502QSJP, Eukaryota |
HOGENOMi | CLU_864384_0_0_1 |
InParanoidi | Q0V7X4 |
OMAi | SHTFRCI |
OrthoDBi | 1155429at2759 |
PhylomeDBi | Q0V7X4 |
Miscellaneous databases
PROi | PR:Q0V7X4 |
Gene expression databases
ExpressionAtlasi | Q0V7X4, baseline and differential |
Genevisiblei | Q0V7X4, AT |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FIT_ARATH | |
Accessioni | Q0V7X4Primary (citable) accession number: Q0V7X4 Secondary accession number(s): Q8S3E9, Q9ZUV8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 16, 2008 |
Last sequence update: | September 5, 2006 | |
Last modified: | April 7, 2021 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names