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Protein

Alcohol dehydrogenase-like 5

Gene

At4g22110

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.By similarity
A secondary alcohol + NAD+ = a ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54Zinc 1; catalyticBy similarity1
Metal bindingi56Zinc 1By similarity1
Binding sitei56NADBy similarity1
Binding sitei56SubstrateBy similarity1
Metal bindingi77Zinc 1; catalyticBy similarity1
Binding sitei77SubstrateBy similarity1
Metal bindingi107Zinc 2By similarity1
Metal bindingi110Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi121Zinc 2By similarity1
Metal bindingi186Zinc 1; catalyticBy similarity1
Binding sitei235NADBy similarity1
Binding sitei240NADBy similarity1
Binding sitei332NAD; via amide nitrogenBy similarity1
Binding sitei382NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi211 – 216NADBy similarity6
Nucleotide bindingi305 – 307NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciARA:AT4G22110-MONOMER
ReactomeiR-ATH-2161541 Abacavir metabolism
R-ATH-5365859 RA biosynthesis pathway
R-ATH-71384 Ethanol oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase-like 5 (EC:1.1.1.1By similarity)
Gene namesi
Ordered Locus Names:At4g22110
ORF Names:F1N20.210
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G22110
TAIRilocus:2120663 AT4G22110

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002991871 – 389Alcohol dehydrogenase-like 5Add BLAST389

Proteomic databases

PaxDbiQ0V7W6
PRIDEiQ0V7W6

Expressioni

Gene expression databases

ExpressionAtlasiQ0V7W6 baseline and differential
GenevisibleiQ0V7W6 AT

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3702.AT4G22110.1

Structurei

3D structure databases

ProteinModelPortaliQ0V7W6
SMRiQ0V7W6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOGENOMiHOG000294674
InParanoidiQ0V7W6
KOiK00121
OMAiHELKFEE
OrthoDBiEOG09360CLU
PhylomeDBiQ0V7W6

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q0V7W6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKTSMFSIH EGKPIRCKAA VSRKPGEALV IEEIHVDPPQ AYEVRIKIIC
60 70 80 90 100
TSLCHTDVSF SKIDSGPLAR FPRILGHEAV GVIESIGEHV NGFQQGDVVL
110 120 130 140 150
PVFHPHCEEC RDCKSSKSNW CARFADDFLS NTRRYGMTSR FKDSFGEDIY
160 170 180 190 200
HFLFVSSFSE YTVVDIAHLV KISPDIPVDK AALLSCGVST GIGAAWKVAN
210 220 230 240 250
VEKGSTVAVF GLGAVGLAVG EGARLRGAGK IIGVDLNPEK FELGKKFGFT
260 270 280 290 300
DFINSTLCGE NKISEVIKEM TGGGVDYSFE CVGLPSLLTE AFSSTRTGSG
310 320 330 340 350
KTVVLGIDKH LTPVSLGSFD LLRGRHVCGS LFGGLKPKLD IPILVDHYLK
360 370 380
KELNLDSFIT HELKFEEINK AFDLLVQGKS LRCILWMNK
Length:389
Mass (Da):42,518
Last modified:September 5, 2006 - v1
Checksum:i816C6BEB08ADDCE4
GO

Sequence cautioni

The sequence AAM67260 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA18114 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB79166 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98V → I in AAM67260 (Ref. 4) Curated1
Sequence conflicti251D → S in AAM67260 (Ref. 4) Curated1
Sequence conflicti255S → P in AAM67260 (Ref. 4) Curated1
Sequence conflicti261N → K in AAM67260 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022140 Genomic DNA Translation: CAA18114.1 Sequence problems.
AL161556 Genomic DNA Translation: CAB79166.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE84551.1
CP002687 Genomic DNA Translation: AEE84552.1
BT026454 mRNA Translation: ABH04561.1
AY084215 mRNA Translation: AAM67260.1 Different initiation.
PIRiT49118
RefSeqiNP_567645.1, NM_118332.2
NP_974589.1, NM_202860.1
UniGeneiAt.32567

Genome annotation databases

EnsemblPlantsiAT4G22110.1; AT4G22110.1; AT4G22110
AT4G22110.2; AT4G22110.2; AT4G22110
GeneIDi828300
GrameneiAT4G22110.1; AT4G22110.1; AT4G22110
AT4G22110.2; AT4G22110.2; AT4G22110
KEGGiath:AT4G22110

Similar proteinsi

Entry informationi

Entry nameiADHL5_ARATH
AccessioniPrimary (citable) accession number: Q0V7W6
Secondary accession number(s): O65459, Q8LGK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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