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Protein

ATP-dependent (S)-NAD(P)H-hydrate dehydratase

Gene

SNOG_04206

Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.UniRule annotation

Catalytic activityi

ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = ADP + phosphate + NADH.UniRule annotation
ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = ADP + phosphate + NADPH.

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei119NAD(P)HX; via amide nitrogenUniRule annotation1
Binding sitei240NAD(P)HXUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi211 – 215ATPUniRule annotation5
Nucleotide bindingi230 – 239ATPUniRule annotation10

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent (S)-NAD(P)H-hydrate dehydrataseUniRule annotation (EC:4.2.1.93UniRule annotation)
Alternative name(s):
ATP-dependent NAD(P)HX dehydrataseUniRule annotation
Gene namesi
ORF Names:SNOG_04206
OrganismiPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
Taxonomic identifieri321614 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora
Proteomesi
  • UP000001055 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004161881 – 325ATP-dependent (S)-NAD(P)H-hydrate dehydrataseAdd BLAST325

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ0UVK8

Interactioni

Protein-protein interaction databases

STRINGi13684.SNOT_04206

Structurei

3D structure databases

ProteinModelPortaliQ0UVK8
SMRiQ0UVK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 315YjeF C-terminalUniRule annotationAdd BLAST307

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni172 – 178NAD(P)HXUniRule annotation7

Sequence similaritiesi

Belongs to the NnrD/CARKD family.UniRule annotation

Phylogenomic databases

InParanoidiQ0UVK8
KOiK17757
OMAiNLMVHPL
OrthoDBiEOG092C4N4W

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR017953 Carbohydrate_kinase_pred_CS
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS01049 YJEF_C_1, 1 hit
PS01050 YJEF_C_2, 1 hit
PS51383 YJEF_C_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q0UVK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASATRKDLL KKVYNMVPPM LESFHKGQLG RVAVIGGSED YTGAPYFSAM
60 70 80 90 100
ASAKLGCDMS HVICEPGAGA VIKTYSPNLM VHPYMRQSKN VGQNENIESI
110 120 130 140 150
KSEVVAMLSR LHVVVIGPGL GRDKLMQDTC AEVIQEARKQ GIPFVLDADG
160 170 180 190 200
LYLAQTRPEL VDGCTECILT PNVVEFGRLA KAKGVNVDEG DPSELCSKLA
210 220 230 240 250
KAFGGVTIIQ KGAKDYISNG SQTLISEGEG GLKRSGGQGD TLTGSLATLL
260 270 280 290 300
AYRKAYHDKI WDHGTNMEPS ETLALAAYGG SCITRECSKL AYKEKGRSLQ
310 320
AADLTEHVHT AFLNVIGEKE ETPKL
Length:325
Mass (Da):34,911
Last modified:September 5, 2006 - v1
Checksum:i842D263CA0BBA742
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH445330 Genomic DNA Translation: EAT87966.1
RefSeqiXP_001794629.1, XM_001794577.1

Genome annotation databases

EnsemblFungiiSNOT_04206; SNOT_04206; SNOG_04206
GeneIDi5971497
KEGGipno:SNOG_04206

Similar proteinsi

Entry informationi

Entry nameiNNRD_PHANO
AccessioniPrimary (citable) accession number: Q0UVK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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