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Protein

Leucine aminopeptidase 2

Gene

SNOG_12761

Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA4 but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B4 as the product compared to the homologous mammalian enzyme (in vitro).By similarity

Catalytic activityi

An epoxide + H2O = a glycol.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi302Zinc; catalyticPROSITE-ProRule annotation1
Active sitei303Proton acceptorPROSITE-ProRule annotation1
Metal bindingi306Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi325Zinc; catalyticPROSITE-ProRule annotation1
Active sitei390Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM01.034

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine aminopeptidase 2 (EC:3.4.11.-)
Alternative name(s):
Epoxide hydrolase (EC:3.3.2.10)
Leukotriene A-4 hydrolase homolog
Short name:
LTA-4 hydrolase
Gene namesi
ORF Names:SNOG_12761
OrganismiPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
Taxonomic identifieri321614 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePhaeosphaeriaceaeParastagonospora
Proteomesi
  • UP000001055 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003249351 – 623Leucine aminopeptidase 2Add BLAST623

Proteomic databases

PRIDEiQ0U653

Interactioni

Protein-protein interaction databases

STRINGi13684.SNOT_12761

Structurei

3D structure databases

ProteinModelPortaliQ0U653
SMRiQ0U653
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni136 – 138Substrate bindingBy similarity3
Regioni273 – 278Substrate bindingBy similarity6

Sequence similaritiesi

Belongs to the peptidase M1 family.Curated

Phylogenomic databases

InParanoidiQ0U653
KOiK01254
OrthoDBiEOG092C0ZZE

Family and domain databases

CDDicd09599 M1_LTA4H, 1 hit
Gene3Di1.10.390.10, 1 hit
1.25.40.320, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR038502 M1_LTA-4_hydro/amino_C_sf
IPR034015 M1_LTA4H
IPR001930 Peptidase_M1
IPR015211 Peptidase_M1_C
IPR014782 Peptidase_M1_N
IPR027268 Peptidase_M4/M1_CTD_sf
PANTHERiPTHR11533 PTHR11533, 1 hit
PfamiView protein in Pfam
PF09127 Leuk-A4-hydro_C, 1 hit
PF01433 Peptidase_M1, 1 hit
PRINTSiPR00756 ALADIPTASE
SMARTiView protein in SMART
SM01263 Leuk-A4-hydro_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q0U653-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METRTPRDPN TLSNYHNYVT RHTSLDFEIE FERKRLVGSV VLRMESLTDA
60 70 80 90 100
EVDVVLDSSF LDVSAIKVDR QSAEFSIGER IEPYGSPLTI KLPAAVPKGK
110 120 130 140 150
TVEIELTVAT TEKCTALQWM EPAQTSNKKH PYMFSQCQAN HARSVFPCQD
160 170 180 190 200
TPDVKSTFSF ALRSPLPVLA SGLPTGASKY QPAKKDGASG TLKYTFEQPV
210 220 230 240 250
AITSYLMAVA SGDLACASIG PRSTVWSGPE ELLECQQELE GEIEPFMKAI
260 270 280 290 300
ESIVKPTYQW TQYNVLILPP SFPYGGMENP VWTYATPSII SGDKQNIDVI
310 320 330 340 350
AHELSHSWSG NLVSAASWEH FWLNEGWTTY LERRIQGVLH GESHRHFSAI
360 370 380 390 400
IGWKALEESI ERYGADHDFT KLVIDLKGKD PDDAFSSIPY EKGFHALYQF
410 420 430 440 450
ELLLGKDKWD NFIPHYFETF KFKSIDSYDF KACLIDFFAK DTEANKKLAE
460 470 480 490 500
FDWDKLFYAP GYPPKPDFDQ TMVKSCYKLA DKWQYLITNN SSSDFKPHHS
510 520 530 540 550
DVADWVSNQS VVFLEKVQSF AEKFSAEQIH LLGHTYGYDK TQNIEVLSRY
560 570 580 590 600
LSAGLMAKAP ETYQPSAELL GRIGRMKFVR PMYRLLEKAD RKLAVETFEK
610 620
NKDFYHPICR SMVEKDLFGD EKK
Length:623
Mass (Da):70,890
Last modified:February 5, 2008 - v2
Checksum:i0012E38B949B27F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH445347 Genomic DNA Translation: EAT80059.2
RefSeqiXP_001802980.1, XM_001802928.1

Genome annotation databases

EnsemblFungiiSNOT_12761; SNOT_12761; SNOG_12761
GeneIDi5979891
KEGGipno:SNOG_12761

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH445347 Genomic DNA Translation: EAT80059.2
RefSeqiXP_001802980.1, XM_001802928.1

3D structure databases

ProteinModelPortaliQ0U653
SMRiQ0U653
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi13684.SNOT_12761

Protein family/group databases

MEROPSiM01.034

Proteomic databases

PRIDEiQ0U653

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSNOT_12761; SNOT_12761; SNOG_12761
GeneIDi5979891
KEGGipno:SNOG_12761

Phylogenomic databases

InParanoidiQ0U653
KOiK01254
OrthoDBiEOG092C0ZZE

Family and domain databases

CDDicd09599 M1_LTA4H, 1 hit
Gene3Di1.10.390.10, 1 hit
1.25.40.320, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR038502 M1_LTA-4_hydro/amino_C_sf
IPR034015 M1_LTA4H
IPR001930 Peptidase_M1
IPR015211 Peptidase_M1_C
IPR014782 Peptidase_M1_N
IPR027268 Peptidase_M4/M1_CTD_sf
PANTHERiPTHR11533 PTHR11533, 1 hit
PfamiView protein in Pfam
PF09127 Leuk-A4-hydro_C, 1 hit
PF01433 Peptidase_M1, 1 hit
PRINTSiPR00756 ALADIPTASE
SMARTiView protein in SMART
SM01263 Leuk-A4-hydro_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLKHA4_PHANO
AccessioniPrimary (citable) accession number: Q0U653
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 5, 2008
Last modified: June 20, 2018
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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