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UniProtKB - Q0TVF9 (ALG3_PHANO)
Protein
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
Gene
ALG3
Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
Status
Functioni
Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol.
By similarityCatalytic activityi
- α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphosphodolichol + dolichyl β-D-mannosyl phosphate = α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→3)-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H+EC:2.4.1.258
: protein glycosylation Pathwayi
This protein is involved in the pathway protein glycosylation, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.
GO - Molecular functioni
- dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity Source: GO_Central
GO - Biological processi
- protein glycosylation Source: GO_Central
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Names & Taxonomyi
Protein namesi | Recommended name: Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (EC:2.4.1.258)Alternative name(s): Asparagine-linked glycosylation protein 6 Dol-P-Man-dependent alpha(1-3)-mannosyltransferase Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase |
Gene namesi | Name:ALG3 ORF Names:SNOG_16505 |
Organismi | Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum) |
Taxonomic identifieri | 321614 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporineae › Phaeosphaeriaceae › Parastagonospora › |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 388 | LumenalSequence analysisAdd BLAST | 388 | |
Transmembranei | 389 – 409 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 410 – 430 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 431 – 451 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 452 – 467 | LumenalSequence analysisAdd BLAST | 16 | |
Transmembranei | 468 – 488 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 489 – 549 | CytoplasmicSequence analysisAdd BLAST | 61 | |
Transmembranei | 550 – 570 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 571 – 609 | LumenalSequence analysisAdd BLAST | 39 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000350932 | 1 – 609 | Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferaseAdd BLAST | 609 |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the ALG3 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2762, Eukaryota |
HOGENOMi | CLU_448416_0_0_1 |
InParanoidi | Q0TVF9 |
OMAi | CERNRHA |
OrthoDBi | 1122031at2759 |
Family and domain databases
Gene3Di | 1.20.1290.10, 1 hit |
InterProi | View protein in InterPro IPR029032, AhpD-like IPR007873, Glycosyltransferase_ALG3 |
PANTHERi | PTHR12646, PTHR12646, 1 hit |
Pfami | View protein in Pfam PF05208, ALG3, 1 hit |
SUPFAMi | SSF69118, SSF69118, 1 hit |
i Sequence
Sequence statusi: Complete.
Q0TVF9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKLSPALKQ LINAAHSRPG PVPAPPRIQA VYQRIQEEAT ERKLGRPSWL
60 70 80 90 100
GISTAATMTM NSPESMIALY NSTSASRPEN ESVQIAEFMR EIGLKCIGFN
110 120 130 140 150
GIPRTINMLN AFRASLPPTI ASSLNTTPTR SPSPQNILDT NTRGRALWDA
160 170 180 190 200
IYRPLETKLI DKLGDAHPDL PVFIINQEYG GLFTDPPGKP GAKVGRVTTS
210 220 230 240 250
LVAITCLRAQ QGVGPQVLSH VFGLRKGWED GTWKEEPEAG SEEAIRWLVS
260 270 280 290 300
DEGCTWVLEK VDELVEALGG GAGTLSPAID EKPKELTTTK TMSLINRVRD
310 320 330 340 350
LATNDEHTRW MIPLLLVVDA ALCGVVIEKI PYTEIDWTTY MQHIALIIKG
360 370 380 390 400
ERDYTKITGS TGPLVYPGAH VWIYKQLFKI TDEGRDIQRA QYIFALVYLG
410 420 430 440 450
TLALVFQCYR KARVPPYVFP LLILSKRLHS IFLLRCFNDC FAVLGLFAAL
460 470 480 490 500
FCYQRDQWHV GSFLFATGLN VKMSLLLPLP AMGVLMIMKL GSREAMTHAM
510 520 530 540 550
IIFQTTVLFG YPFRKAAFSY FGRAFELSRQ FTYKWTVNWR FVSEETFLSK
560 570 580 590 600
PFALGLLSVH VTLLITFFLT RWIKPSKRTP KQFLKIIMPQ AEPRDQDTMA
LRITPNLHT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH445373 Genomic DNA Translation: EAT76110.2 |
RefSeqi | XP_001806617.1, XM_001806565.1 |
Genome annotation databases
EnsemblFungii | SNOT_16505; SNOT_16505; SNOG_16505 |
GeneIDi | 5983549 |
KEGGi | pno:SNOG_16505 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH445373 Genomic DNA Translation: EAT76110.2 |
RefSeqi | XP_001806617.1, XM_001806565.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 13684.SNOT_16505 |
Genome annotation databases
EnsemblFungii | SNOT_16505; SNOT_16505; SNOG_16505 |
GeneIDi | 5983549 |
KEGGi | pno:SNOG_16505 |
Phylogenomic databases
eggNOGi | KOG2762, Eukaryota |
HOGENOMi | CLU_448416_0_0_1 |
InParanoidi | Q0TVF9 |
OMAi | CERNRHA |
OrthoDBi | 1122031at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Family and domain databases
Gene3Di | 1.20.1290.10, 1 hit |
InterProi | View protein in InterPro IPR029032, AhpD-like IPR007873, Glycosyltransferase_ALG3 |
PANTHERi | PTHR12646, PTHR12646, 1 hit |
Pfami | View protein in Pfam PF05208, ALG3, 1 hit |
SUPFAMi | SSF69118, SSF69118, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ALG3_PHANO | |
Accessioni | Q0TVF9Primary (citable) accession number: Q0TVF9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 23, 2008 |
Last sequence update: | February 5, 2008 | |
Last modified: | September 29, 2021 | |
This is version 73 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families