UniProtKB - Q0TUN8 (ECFA3_CLOP1)
Protein
Energy-coupling factor transporter ATP-binding protein EcfA3
Gene
ecfA3
Organism
Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Status
Functioni
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 39 – 46 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- cobalt ion transport Source: InterPro
- transmembrane transport Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | CPER195103:G1G5R-192-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Energy-coupling factor transporter ATP-binding protein EcfA3UniRule annotation (EC:3.6.3.-UniRule annotation)Short name: ECF transporter A component EcfA3UniRule annotation |
Gene namesi | Name:ecfA3UniRule annotation Synonyms:cbiO1 Ordered Locus Names:CPF_0188 |
Organismi | Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A) |
Taxonomic identifieri | 195103 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › |
Proteomesi |
|
Subcellular locationi
- Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation
GO - Cellular componenti
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287932 | 1 – 285 | Energy-coupling factor transporter ATP-binding protein EcfA3Add BLAST | 285 |
Interactioni
Subunit structurei
Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
UniRule annotationProtein-protein interaction databases
STRINGi | 195103.CPF_0188 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q0TUN8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q0TUN8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 242 | ABC transporterUniRule annotationAdd BLAST | 237 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG1122, Bacteria |
HOGENOMi | CLU_000604_1_22_9 |
OMAi | LQDPDDQ |
OrthoDBi | 1752365at2 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR015856, ABC_transpr_CbiO/EcfA_su IPR005876, Co_trans_ATP-bd IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01166, cbiO, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit PS51246, CBIO, 1 hit |
i Sequence
Sequence statusi: Complete.
Q0TUN8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEDYILKVEE LNYNYSDGTH ALKGINMNIK RGEVTAILGG NGVGKSTLFQ
60 70 80 90 100
NFNGILKPSS GRILFDNKPI DYSRKGIMKL RESIGIVFQD PDNQLFSASV
110 120 130 140 150
YQDVSFGAVN MKLPEDEIRK RVDNALKRTG IEHLKDKPTH CLSFGQKKRV
160 170 180 190 200
AIAGVLVMEP KVLILDEPTA GLDPMGVSEI MKLLVEMQKE LGITIIIATH
210 220 230 240 250
DIDIVPLYCD NVFVMKEGRV ILQGNPKEVF AEKEVIRKVN LRLPRIGHLM
260 270 280
EILKEKDGFV FDELDLTIGQ ARKTINSWKN KIFND
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000246 Genomic DNA Translation: ABG82220.1 |
RefSeqi | WP_003457507.1, NC_008261.1 |
Genome annotation databases
EnsemblBacteriai | ABG82220; ABG82220; CPF_0188 |
GeneIDi | 29572690 |
KEGGi | cpf:CPF_0188 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000246 Genomic DNA Translation: ABG82220.1 |
RefSeqi | WP_003457507.1, NC_008261.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3GFO | X-ray | 2.30 | A | 2-265 | [»] | |
SMRi | Q0TUN8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 195103.CPF_0188 |
Protocols and materials databases
DNASUi | 4201231 |
Genome annotation databases
EnsemblBacteriai | ABG82220; ABG82220; CPF_0188 |
GeneIDi | 29572690 |
KEGGi | cpf:CPF_0188 |
Phylogenomic databases
eggNOGi | COG1122, Bacteria |
HOGENOMi | CLU_000604_1_22_9 |
OMAi | LQDPDDQ |
OrthoDBi | 1752365at2 |
Enzyme and pathway databases
BioCyci | CPER195103:G1G5R-192-MONOMER |
Miscellaneous databases
EvolutionaryTracei | Q0TUN8 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR015856, ABC_transpr_CbiO/EcfA_su IPR005876, Co_trans_ATP-bd IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01166, cbiO, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit PS51246, CBIO, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ECFA3_CLOP1 | |
Accessioni | Q0TUN8Primary (citable) accession number: Q0TUN8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | September 5, 2006 | |
Last modified: | December 2, 2020 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families