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Protein

Alanine racemase

Gene

alr

Organism
Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr), Alanine racemase (CPF_1317)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei38Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei136SubstrateUniRule annotation1
Active sitei267Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei315Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayi
UPA00042;UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Ordered Locus Names:CPF_0861
OrganismiClostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001823 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000659801 – 386Alanine racemaseAdd BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ0TSS9

Interactioni

Protein-protein interaction databases

STRINGi195103.CPF_0861

Structurei

3D structure databases

ProteinModelPortaliQ0TSS9
SMRiQ0TSS9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWRGPILL
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q0TSS9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDICVRPVWA EIDLDIIANN MKEIRNLVGE KEIIAVVKAN AYGHGALDIA
60 70 80 90 100
STLLENGASR LAVAIITEAD ELRDAGITAP IMILGYTPIN FAENLINNEI
110 120 130 140 150
EQTVYDVEYA KELSDFALKL GKKAKVHIAI DTGMGRIGFL PNEEGLNKVL
160 170 180 190 200
EICSLPGVEV IGLFTHFSTS DEKDKTYTYE QFSKLTAFNK ALEDNGIHIP
210 220 230 240 250
LKHASNSGAI MDLPETYLDG VRCGIISYGY YPSEEVKKEN LKLKPALTLK
260 270 280 290 300
TNVAFVKELD EDMYVSYGRT YKTEKKSKIA TLPIGYADGY SRLLSGKAKV
310 320 330 340 350
IIKGQFANVI GRVCMDQCMI DVTHIEDVKI GDEVILLGEE NGLKFDANDM
360 370 380
AEIMGTINYE ILCMISHRVP RIYKKNNEIV KVINYI
Length:386
Mass (Da):42,903
Last modified:September 5, 2006 - v1
Checksum:iBE2AEB20092AF89A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000246 Genomic DNA Translation: ABG82585.1
RefSeqiWP_011590407.1, NC_008261.1

Genome annotation databases

EnsemblBacteriaiABG82585; ABG82585; CPF_0861
GeneIDi29572020
KEGGicpf:CPF_0861

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000246 Genomic DNA Translation: ABG82585.1
RefSeqiWP_011590407.1, NC_008261.1

3D structure databases

ProteinModelPortaliQ0TSS9
SMRiQ0TSS9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi195103.CPF_0861

Proteomic databases

PRIDEiQ0TSS9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG82585; ABG82585; CPF_0861
GeneIDi29572020
KEGGicpf:CPF_0861

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWRGPILL
OrthoDBiPOG091H022F

Enzyme and pathway databases

UniPathwayi
UPA00042;UER00497

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALR_CLOP1
AccessioniPrimary (citable) accession number: Q0TSS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 5, 2006
Last modified: October 10, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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