UniProtKB - Q0T8H6 (DNAK_SHIF8)
Protein
Chaperone protein DnaK
Gene
dnaK
Organism
Shigella flexneri serotype 5b (strain 8401)
Status
Functioni
Acts as a chaperone.UniRule annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- unfolded protein binding Source: InterPro
GO - Biological processi
- protein folding Source: InterPro
Keywordsi
Molecular function | Chaperone |
Biological process | Stress response |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | SFLE373384:SFV_RS00070-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Chaperone protein DnaKUniRule annotationAlternative name(s): HSP70UniRule annotation Heat shock 70 kDa proteinUniRule annotation Heat shock protein 70UniRule annotation |
Gene namesi | Name:dnaKUniRule annotation Ordered Locus Names:SFV_0012 |
Organismi | Shigella flexneri serotype 5b (strain 8401) |
Taxonomic identifieri | 373384 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Shigella › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000059669 | 1 – 638 | Chaperone protein DnaKAdd BLAST | 638 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 109 | N6-acetyllysineUniRule annotation | 1 | |
Modified residuei | 199 | Phosphothreonine; by autocatalysisUniRule annotation | 1 | |
Modified residuei | 245 | N6-acetyllysineUniRule annotation | 1 | |
Modified residuei | 304 | N6-acetyllysineUniRule annotation | 1 | |
Modified residuei | 421 | N6-acetyllysineUniRule annotation | 1 | |
Modified residuei | 556 | N6-acetyllysineUniRule annotation | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PRIDEi | Q0T8H6 |
Expressioni
Inductioni
By stress conditions e.g. heat shock.UniRule annotation
Family & Domainsi
Sequence similaritiesi
Belongs to the heat shock protein 70 family.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000228136 |
KOi | K04043 |
OMAi | ISIKRHM |
Family and domain databases
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
HAMAPi | MF_00332 DnaK, 1 hit |
InterProi | View protein in InterPro IPR012725 Chaperone_DnaK IPR018181 Heat_shock_70_CS IPR029048 HSP70_C_sf IPR029047 HSP70_peptide-bd_sf IPR013126 Hsp_70_fam |
PANTHERi | PTHR19375 PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012 HSP70, 1 hit |
SUPFAMi | SSF100920 SSF100920, 1 hit SSF100934 SSF100934, 1 hit |
TIGRFAMsi | TIGR02350 prok_dnaK, 1 hit |
PROSITEi | View protein in PROSITE PS00297 HSP70_1, 1 hit PS00329 HSP70_2, 1 hit PS01036 HSP70_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q0T8H6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKIIGIDLG TTNSCVAIMD GTIPRVLENA EGDRTTPSII AYTQDGETLV
60 70 80 90 100
GQPAKRQAVT NPQNTLFAIK RLIGRRFQDE EVQRDVSIMP FKIIAADNGD
110 120 130 140 150
AWVEVKGQKM APPQISAEVL KKMKKTAEDY LGEPVTEAVI TVPAYFNDAQ
160 170 180 190 200
RQATKDAGRI AGLEVKRIIN EPTAAALAYG LDKGTGNRTI AVYDLGGGTF
210 220 230 240 250
DISIIEIDEV DGEKTFEVLA TNGDTHLGGE DFDSRLINYL VEEFKKDQGI
260 270 280 290 300
DLRNDPLAMQ RLKEAAEKAK IELSSAQQTD VNLPYITADA TGPKHMNIKV
310 320 330 340 350
TRAKLESLVE DLVNRSIEPL KVALQDAGLS VSDIDDVILV GGQTRMPMVQ
360 370 380 390 400
KKVAEFFGKE PRKDVNPDEA VAIGAAVQGG VLTGDVKDVL LLDVTPLSLG
410 420 430 440 450
IETMGGVMTT LIAKNTTIPT KHSQVFSTAE DNQSAVTIHV LQGERKRAAD
460 470 480 490 500
NKSLGQFNLD GINPAPRGMP QIEVTFDIDA DGILHVSAKD KNSGKEQKIT
510 520 530 540 550
IKASSGLNED EIQKMVRDAE ANAEADRKFE ELVQTRNQGD HLLHSTRKQV
560 570 580 590 600
EEAGDKLPAD DKTAIESALT ALETALKGED KAAIEAKMQE LAQVSQKLME
610 620 630
IAQQQHAQQQ TAGADASANN AKDDDVVDAE FEEVKDKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000266 Genomic DNA Translation: ABF02300.1 |
RefSeqi | WP_000516121.1, NC_008258.1 |
Genome annotation databases
EnsemblBacteriai | ABF02300; ABF02300; SFV_0012 |
KEGGi | sfv:SFV_0012 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000266 Genomic DNA Translation: ABF02300.1 |
RefSeqi | WP_000516121.1, NC_008258.1 |
3D structure databases
SMRi | Q0T8H6 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q0T8H6 |
Genome annotation databases
EnsemblBacteriai | ABF02300; ABF02300; SFV_0012 |
KEGGi | sfv:SFV_0012 |
Phylogenomic databases
HOGENOMi | HOG000228136 |
KOi | K04043 |
OMAi | ISIKRHM |
Enzyme and pathway databases
BioCyci | SFLE373384:SFV_RS00070-MONOMER |
Family and domain databases
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
HAMAPi | MF_00332 DnaK, 1 hit |
InterProi | View protein in InterPro IPR012725 Chaperone_DnaK IPR018181 Heat_shock_70_CS IPR029048 HSP70_C_sf IPR029047 HSP70_peptide-bd_sf IPR013126 Hsp_70_fam |
PANTHERi | PTHR19375 PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012 HSP70, 1 hit |
SUPFAMi | SSF100920 SSF100920, 1 hit SSF100934 SSF100934, 1 hit |
TIGRFAMsi | TIGR02350 prok_dnaK, 1 hit |
PROSITEi | View protein in PROSITE PS00297 HSP70_1, 1 hit PS00329 HSP70_2, 1 hit PS01036 HSP70_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DNAK_SHIF8 | |
Accessioni | Q0T8H6Primary (citable) accession number: Q0T8H6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | September 5, 2006 | |
Last modified: | November 13, 2019 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteomeDocuments
- SIMILARITY comments
Index of protein domains and families