arnD

Functionⁱ

Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

Catalytic activityⁱ

4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H₂O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate.UniRule annotation

Pathwayⁱ: 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase (arnC)
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD (arnD)

This subpathway is part of the pathway 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate, the pathway 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis and in Glycolipid biosynthesis.

Pathwayⁱ: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functionⁱ

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process Source: UniProtKB-UniPathway
lipid A biosynthetic process Source: UniProtKB-KW
lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
response to antibiotic Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Antibiotic resistance, Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayⁱ	UPA00030 UPA00036; UER00496

UniPathwayⁱ

UPA00030
UPA00036; UER00496

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDUniRule annotation (EC:3.5.1.n3UniRule annotation)
Gene namesⁱ	Name:arnDUniRule annotation Ordered Locus Names:SFV_2326
Organismⁱ	Shigella flexneri serotype 5b (strain 8401)
Taxonomic identifierⁱ	373384 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Shigella › Shigella flexneri › Shigella flexneri 5
Proteomesⁱ	UP000000659 Componentⁱ: Chromosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000383546	1 – 296	Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDAdd BLAST		296

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q0T2M7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 260	NodB homologyUniRule annotationAdd BLAST		259

Sequence similaritiesⁱ

Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000261199
KEGG Orthology (KO) More...KOⁱ	K13014
OMAⁱ	KFLWKML

Family and domain databases

HAMAPⁱ	MF_01870 ArnD, 1 hit
InterProⁱ	View protein in InterPro IPR023557 ArnD IPR011330 Glyco_hydro/deAcase_b/a-brl IPR002509 NODB_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01522 Polysacc_deac_1, 1 hit
SUPFAMⁱ	SSF88713 SSF88713, 2 hits
PROSITEⁱ	View protein in PROSITE PS51677 NODB, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q0T2M7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTKVGLRIDV DTFRGTREGV PRLLEILSKH NIQASIFFSV GPDNMGRHLW 
        60         70         80         90        100
RLVKPQFLWK MLRSNAASLY GWDILLAGTA WPGKEIGHAN ADIIREAAKH 
       110        120        130        140        150
HEVGLHAWDH HAWQARSGNW DRQTMIDDIA RGLRTLEEII GQPVTCSAAA 
       160        170        180        190        200
GWRADQKVIE AKEAFHLRYN SDCRGAMPFR PLLESGNPGT AQIPVTLPTW 
       210        220        230        240        250
DEVIGRDVKA EDFNGWLLNR ILRDKGTPVY TIHAEVEGCA YQHNFVDLLK 
       260        270        280        290 
RAAQEGVTFC PLSELLSETL PLGQVVRGNI AGREGWLGCQ QIAGSR

Length:296

Mass (Da):33,112

Last modified:October 31, 2006 - v1

Checksum:ⁱDDD0BEE55581DE3C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000266 Genomic DNA Translation: ABF04438.1

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

CP000266 Genomic DNA Translation: ABF04438.1

Genome annotation databases

EnsemblBacteriaⁱ	ABF04438; ABF04438; SFV_2326
KEGGⁱ	sfv:SFV_2326

Protein	Similar proteins		Species	Score	Length
Q0T2M7	Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECODH		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECOHS		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECOLC		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECOLI		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		SHISS		296
+80

Protein	Similar proteins		Species	Score	Length
Q0T2M7	Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECO57		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECO5E		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECOLX		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECOCB		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECO5C		296
+522

Protein	Similar proteins		Species	Score	Length
Q0T2M7	Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECO57		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECO5E		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECOLX		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECOCB		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECO5C		296
+2269

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000266 Genomic DNA Translation: ABF04438.1

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

CP000266 Genomic DNA Translation: ABF04438.1

3D structure databases

ProteinModelPortalⁱ	Q0T2M7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABF04438; ABF04438; SFV_2326
KEGGⁱ	sfv:SFV_2326

Phylogenomic databases

HOGENOMⁱ	HOG000261199
KEGG Orthology (KO) More...KOⁱ	K13014
OMAⁱ	KFLWKML

Enzyme and pathway databases

UniPathwayⁱ	UPA00030 UPA00036; UER00496

UniPathwayⁱ

UPA00030
UPA00036; UER00496

Family and domain databases

HAMAPⁱ	MF_01870 ArnD, 1 hit
InterProⁱ	View protein in InterPro IPR023557 ArnD IPR011330 Glyco_hydro/deAcase_b/a-brl IPR002509 NODB_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01522 Polysacc_deac_1, 1 hit
SUPFAMⁱ	SSF88713 SSF88713, 2 hits
PROSITEⁱ	View protein in PROSITE PS51677 NODB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ARND_SHIF8
Accessionⁱ	Q0T2M7Primary (citable) accession number: Q0T2M7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
	Last sequence update:	October 31, 2006
	Last modified:	April 25, 2018
	This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB - Q0T2M7 (ARND_SHIF8)

Your basket is currently empty. ⁱ

Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

Select a section on the left to see content.

Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis

Pathwayⁱ: lipopolysaccharide biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

PTM / Processingⁱ

Molecule processing

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q0T2M7 (ARND_SHIF8)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

arnD

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: lipopolysaccharide biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Pathwayⁱ: lipopolysaccharide biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ