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Protein

Cardiolipin synthase

Gene

cls

Organism
Clostridium perfringens (strain SM101 / Type A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei212UniRule annotation1
Active sitei214UniRule annotation1
Active sitei219UniRule annotation1
Active sitei394UniRule annotation1
Active sitei396UniRule annotation1
Active sitei401UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthaseUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:cls
Ordered Locus Names:CPR_1418
OrganismiClostridium perfringens (strain SM101 / Type A)
Taxonomic identifieri289380 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001824 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalUniRule annotationAdd BLAST21
Transmembranei31 – 51HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000584801 – 476Cardiolipin synthaseAdd BLAST476

Proteomic databases

PRIDEiQ0ST20

Structurei

3D structure databases

ProteinModelPortaliQ0ST20
SMRiQ0ST20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 234PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini389 – 416PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000077402
KOiK06131
OMAiANRRMHN

Family and domain databases

HAMAPiMF_01916 Cardiolipin_synth_Cls, 1 hit
InterProiView protein in InterPro
IPR030874 Cardiolipin_synth_Firmi
IPR022924 Cardiolipin_synthase
IPR027379 CLS_N
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
PF13396 PLDc_N, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
TIGRFAMsiTIGR04265 bac_cardiolipin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

Q0ST20-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLLINIIFL INIIFIISII FIERRNPQTT WAWILILTFL PILGFIIYIL
60 70 80 90 100
FGQNITREKN FKRKILDDKT KQKYLNSFKS HYKLDNISLK YKDLIMMNFN
110 120 130 140 150
NDNSTYTQRN DIDLYFDANS LFQEMIYEIN KAEKFIHMEF YIFKSDEIGK
160 170 180 190 200
KILQALTKKA KEGVEVKLLV DSIGNSIHKK DIDKLKAAGG DFKIFFPGFC
210 220 230 240 250
KYINLRINYR NHRKILIIDS KVAFLGGFNI GDEYLGKDKN IGNWRDTHTK
260 270 280 290 300
IKGLAINDLE ARFLLDWSYA NESDLDIDLK KYFINPHSTN LPNNIIGAQI
310 320 330 340 350
VSSGPDHTEQ QIKNGYFKII NSAKKNLFIQ TPYFVPDEPM LEALRLAALS
360 370 380 390 400
GVDVKIMLPG NPDHKFMEWI ANSYFESLLN AGVKIYLYEK GFLHAKTIVA
410 420 430 440 450
DSSICSVGTA NMDIRSFSLN FESNIFIYNE AISKSMEEQF FKDLKVCTKV
460 470
TLESFEKRSI ISRIGESIIR LVSPLM
Length:476
Mass (Da):55,123
Last modified:September 5, 2006 - v1
Checksum:iAC5BF115D4CA3927
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000312 Genomic DNA Translation: ABG86629.1

Genome annotation databases

EnsemblBacteriaiABG86629; ABG86629; CPR_1418
KEGGicpr:CPR_1418

Similar proteinsi

Entry informationi

Entry nameiCLS_CLOPS
AccessioniPrimary (citable) accession number: Q0ST20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 5, 2006
Last modified: July 18, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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