cofC2

Functionⁱ

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityⁱ

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayⁱ: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functionⁱ

GTP binding Source: UniProtKB-KW
nucleotidyltransferase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Nucleotidyltransferase, Transferase
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	RJOS101510:G1G71-8962-MONOMER
UniPathwayⁱ	UPA00071

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 2-phospho-L-lactate guanylyltransferase 2UniRule annotation (EC:2.7.7.68UniRule annotation) Short name: LP guanylyltransferase 2UniRule annotation
Gene namesⁱ	Name:cofC2UniRule annotation Ordered Locus Names:RHA1_ro11040
Encoded onⁱ	Plasmid pRHL30 Publication
Organismⁱ	Rhodococcus jostii (strain RHA1)
Taxonomic identifierⁱ	101510 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Actinobacteria › Actinobacteria › Corynebacteriales › Nocardiaceae › Rhodococcus › Rhodococcus jostii
Proteomesⁱ	UP000008710 Componentⁱ: Plasmid pRHL3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000398708	1 – 214	2-phospho-L-lactate guanylyltransferase 2Add BLAST		214

Structureⁱ

3D structure databases

SMRⁱ	Q0RVJ9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000223639
KEGG Orthology (KO) More...KOⁱ	K14941
OMAⁱ	MARWCAV
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0B3J

Family and domain databases

Gene3Dⁱ	3.90.550.10, 1 hit
HAMAPⁱ	MF_02114 CofC, 1 hit
InterProⁱ	View protein in InterPro IPR002835 Coenzyme_F420_CofC IPR029044 Nucleotide-diphossugar_trans
PANTHERⁱ	PTHR40392 PTHR40392, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01983 CofC, 1 hit
SUPFAMⁱ	SSF53448 SSF53448, 1 hit
TIGRFAMsⁱ	TIGR03552 F420_cofC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q0RVJ9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSDYGEWAVI VPFRSLDVAK SRLAVSCRRD LALAFLQDTL AALTLSNHIS 
        60         70         80         90        100
SVIVVSRNAA LSETIGTPVI KDQGSGIDDA VEIGHRWLRE HGHDGHYSVV 
       110        120        130        140        150
MPDLPALRTG DIDNFLSAAS RFPRAFVADS AGTGTTCLTT QQAAILSAFG 
       160        170        180        190        200
RNSAQRHTRM GYKQIPLGLP SLRLDVDTID DLERAARMGV GRHTQRLLIS 
       210 
NNELHSLRFP CAPG

Length:214

Mass (Da):23,243

Last modified:September 5, 2006 - v1

Checksum:ⁱBB9ECCEF3CA90D1C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000434 Genomic DNA Translation: ABH00687.1
NCBI Reference Sequences More...RefSeqⁱ	WP_011600315.1, NC_008271.1

Genome annotation databases

EnsemblBacteriaⁱ	ABH00687; ABH00687; RHA1_ro11040
GeneIDⁱ	4226473
KEGGⁱ	rha:RHA1_ro11040

Entry informationⁱ

Entry nameⁱ	COFC2_RHOJR
Accessionⁱ	Q0RVJ9Primary (citable) accession number: Q0RVJ9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 5, 2010
	Last sequence update:	September 5, 2006
	Last modified:	September 12, 2018
	This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Plasmid

UniProtKB - Q0RVJ9 (COFC2_RHOJR)

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2-phospho-L-lactate guanylyltransferase 2

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: coenzyme F420 biosynthesis

GO - Molecular functionⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

PTM / Processingⁱ

Molecule processing

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

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Annotation systems

Supporting data

UniProtKB - Q0RVJ9 (COFC2_RHOJR)

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2-phospho-L-lactate guanylyltransferase 2

cofC2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: coenzyme F420 biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

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Functionⁱ

Pathwayⁱ: coenzyme F420 biosynthesis

GO - Molecular functionⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ