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UniProtKB - Q0RVJ9 (FBID2_RHOJR)
Protein
Phosphoenolpyruvate guanylyltransferase 2
Gene
fbiD
Organism
Rhodococcus jostii (strain RHA1)
Status
Functioni
Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
UniRule annotationCatalytic activityi
- GTP + H+ + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosineUniRule annotationEC:2.7.7.105UniRule annotation
: coenzyme F420 biosynthesis Pathwayi
This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotationView all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 135 | Phosphoenolpyruvate; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 150 | Phosphoenolpyruvate; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 153 | PhosphoenolpyruvateUniRule annotation | 1 |
GO - Molecular functioni
- GTP binding Source: UniProtKB-KW
- phospholactate guanylyltransferase activity Source: InterPro
GO - Biological processi
- F420-0 metabolic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00071 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphoenolpyruvate guanylyltransferase 2UniRule annotation (EC:2.7.7.105UniRule annotation)Short name: PEP guanylyltransferase 2UniRule annotation |
Gene namesi | Name:fbiDUniRule annotation Ordered Locus Names:RHA1_ro11040 |
Encoded oni | Plasmid pRHL3 |
Organismi | Rhodococcus jostii (strain RHA1) |
Taxonomic identifieri | 101510 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Nocardiaceae › Rhodococcus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000398708 | 1 – 214 | Phosphoenolpyruvate guanylyltransferase 2Add BLAST | 214 |
Family & Domainsi
Sequence similaritiesi
Belongs to the CofC family.UniRule annotation
Phylogenomic databases
eggNOGi | COG1920, Bacteria |
HOGENOMi | CLU_076569_0_0_11 |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
HAMAPi | MF_02114, CofC, 1 hit |
InterProi | View protein in InterPro IPR002835, CofC IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR40392, PTHR40392, 1 hit |
Pfami | View protein in Pfam PF01983, CofC, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
TIGRFAMsi | TIGR03552, F420_cofC, 1 hit |
i Sequence
Sequence statusi: Complete.
Q0RVJ9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDYGEWAVI VPFRSLDVAK SRLAVSCRRD LALAFLQDTL AALTLSNHIS
60 70 80 90 100
SVIVVSRNAA LSETIGTPVI KDQGSGIDDA VEIGHRWLRE HGHDGHYSVV
110 120 130 140 150
MPDLPALRTG DIDNFLSAAS RFPRAFVADS AGTGTTCLTT QQAAILSAFG
160 170 180 190 200
RNSAQRHTRM GYKQIPLGLP SLRLDVDTID DLERAARMGV GRHTQRLLIS
210
NNELHSLRFP CAPG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000434 Genomic DNA Translation: ABH00687.1 |
RefSeqi | WP_011600315.1, NC_008271.1 |
Genome annotation databases
EnsemblBacteriai | ABH00687; ABH00687; RHA1_ro11040 |
KEGGi | rha:RHA1_ro11040 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000434 Genomic DNA Translation: ABH00687.1 |
RefSeqi | WP_011600315.1, NC_008271.1 |
3D structure databases
AlphaFoldDBi | Q0RVJ9 |
SMRi | Q0RVJ9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 101510.RHA1_ro11040 |
Genome annotation databases
EnsemblBacteriai | ABH00687; ABH00687; RHA1_ro11040 |
KEGGi | rha:RHA1_ro11040 |
Phylogenomic databases
eggNOGi | COG1920, Bacteria |
HOGENOMi | CLU_076569_0_0_11 |
Enzyme and pathway databases
UniPathwayi | UPA00071 |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
HAMAPi | MF_02114, CofC, 1 hit |
InterProi | View protein in InterPro IPR002835, CofC IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR40392, PTHR40392, 1 hit |
Pfami | View protein in Pfam PF01983, CofC, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
TIGRFAMsi | TIGR03552, F420_cofC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FBID2_RHOJR | |
Accessioni | Q0RVJ9Primary (citable) accession number: Q0RVJ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 5, 2010 |
Last sequence update: | September 5, 2006 | |
Last modified: | May 25, 2022 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Plasmid, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families