UniProtKB - Q0QEL7 (CISY_MESAU)
Protein
Citrate synthase, mitochondrial
Gene
CS
Organism
Mesocricetus auratus (Golden hamster)
Status
Functioni
Miscellaneous
Citrate synthase is found in nearly all cells capable of oxidative metabolism.Curated
Catalytic activityi
- EC:2.3.3.1PROSITE-ProRule annotationBy similarity
: tricarboxylic acid cycle Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.By similarityProteins known to be involved in the 2 steps of the subpathway in this organism are:
- Citrate synthase, mitochondrial (CS), Citrate synthase (Cs), Citrate synthase (Cs)
- Aconitate hydratase, mitochondrial (Aco2)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 74 | PROSITE-ProRule annotationBy similarity | 1 | |
Active sitei | 120 | PROSITE-ProRule annotationBy similarity | 1 | |
Active sitei | 175 | PROSITE-ProRule annotationBy similarity | 1 |
GO - Molecular functioni
- citrate (Si)-synthase activity Source: UniProtKB-EC
GO - Biological processi
- tricarboxylic acid cycle Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Transferase |
Biological process | Tricarboxylic acid cycle |
Enzyme and pathway databases
UniPathwayi | UPA00223;UER00717 |
Names & Taxonomyi
Protein namesi | Recommended name: Citrate synthase, mitochondrialBy similarity (EC:2.3.3.1)Alternative name(s): Citrate (Si)-synthase |
Gene namesi | Name:CSImported |
Organismi | Mesocricetus auratus (Golden hamster) |
Taxonomic identifieri | 10036 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Cricetidae › Cricetinae › Mesocricetus |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion matrix By similarity
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000394310 | ‹1 – ›213 | Citrate synthase, mitochondrialAdd BLAST | ›213 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 94 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 94 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 100 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 100 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 148 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 148 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 155 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 166 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 166 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 168 | N6,N6,N6-trimethyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, MethylationProteomic databases
PRIDEi | Q0QEL7 |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 10036.XP_005079779.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the citrate synthase family.Sequence analysis
Phylogenomic databases
eggNOGi | KOG2617, Eukaryota |
Family and domain databases
Gene3Di | 1.10.230.10, 1 hit 1.10.580.10, 1 hit |
InterProi | View protein in InterPro IPR016142, Citrate_synth-like_lrg_a-sub IPR016143, Citrate_synth-like_sm_a-sub IPR002020, Citrate_synthase IPR019810, Citrate_synthase_AS IPR036969, Citrate_synthase_sf |
PANTHERi | PTHR11739, PTHR11739, 1 hit |
Pfami | View protein in Pfam PF00285, Citrate_synt, 1 hit |
PRINTSi | PR00143, CITRTSNTHASE |
SUPFAMi | SSF48256, SSF48256, 1 hit |
PROSITEi | View protein in PROSITE PS00480, CITRATE_SYNTHASE, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q0QEL7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
GAIDSKLDWS HNFTNMLGYT EPQFTELMRL YLTIHSDHEG GNVSAHTSHL
60 70 80 90 100
VGSALSDPYL SFAAAMNGLA GPLHGLANQE VLVWLTQLQK EVGKDVSDEK
110 120 130 140 150
LRDYIWNTLN SGRVVPGYGH AVLRKTDPRY SCQREFALKH LPNDPLFKLV
160 170 180 190 200
AQLYKIVPNI LLEQGKAKNP WPNVDAHSGV LLQYYGMTEM NYYTVLFGVS
210
RALGVLAQLI WSR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 213 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ403127 mRNA Translation: ABD77260.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ403127 mRNA Translation: ABD77260.1 |
3D structure databases
SMRi | Q0QEL7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10036.XP_005079779.1 |
Proteomic databases
PRIDEi | Q0QEL7 |
Phylogenomic databases
eggNOGi | KOG2617, Eukaryota |
Enzyme and pathway databases
UniPathwayi | UPA00223;UER00717 |
Family and domain databases
Gene3Di | 1.10.230.10, 1 hit 1.10.580.10, 1 hit |
InterProi | View protein in InterPro IPR016142, Citrate_synth-like_lrg_a-sub IPR016143, Citrate_synth-like_sm_a-sub IPR002020, Citrate_synthase IPR019810, Citrate_synthase_AS IPR036969, Citrate_synthase_sf |
PANTHERi | PTHR11739, PTHR11739, 1 hit |
Pfami | View protein in Pfam PF00285, Citrate_synt, 1 hit |
PRINTSi | PR00143, CITRTSNTHASE |
SUPFAMi | SSF48256, SSF48256, 1 hit |
PROSITEi | View protein in PROSITE PS00480, CITRATE_SYNTHASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CISY_MESAU | |
Accessioni | Q0QEL7Primary (citable) accession number: Q0QEL7 Secondary accession number(s): P86224 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 18, 2010 |
Last sequence update: | September 5, 2006 | |
Last modified: | August 12, 2020 | |
This is version 57 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families