Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q0Q4F2 (SPIKE_BC133)

Entry version 92 (26 Feb. 2020)
Sequence version 1 (05 Sep. 2006)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Spike glycoprotein

Gene

S

Organism
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.UniRule annotation
mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.UniRule annotation
Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processFusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virulence, Virus entry into host cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spike glycoproteinUniRule annotation
Short name:
S glycoproteinUniRule annotation
Alternative name(s):
E2UniRule annotation
Peplomer proteinUniRule annotation
Cleaved into the following 3 chains:
Spike protein S1UniRule annotation
Spike protein S2UniRule annotation
Spike protein S2'UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SUniRule annotation
ORF Names:2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri389230 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Merbecovirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiTylonycteris pachypus (Lesser bamboo bat) [TaxID: 258959]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007449 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini13 – 1295ExtracellularUniRule annotationAdd BLAST1283
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1296 – 1316HelicalUniRule annotationAdd BLAST21
Topological domaini1317 – 1350CytoplasmicUniRule annotationAdd BLAST34

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 12UniRule annotationAdd BLAST12
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000029031813 – 1350Spike glycoproteinAdd BLAST1338
ChainiPRO_000029031913 – 749Spike protein S1Add BLAST737
ChainiPRO_0000290320750 – 1235Spike protein S2Add BLAST486
ChainiPRO_0000444058885 – 1350Spike protein S2'UniRule annotationAdd BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi30N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi71N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi111N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi132N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi162N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi172N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi227N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi241N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi384N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi388 ↔ 412UniRule annotation
Glycosylationi415N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Disulfide bondi430 ↔ 483UniRule annotation
Glycosylationi492N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi624N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi723N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi762N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi773N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi784N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi869N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1142N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1145N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1172N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1224N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1240N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1255N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1276N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1287N-linked (GlcNAc...) asparagine; by hostUniRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins.By similarity
Specific enzymatic cleavages in vivo yield mature proteins. The precursor is processed into S1 and S2 by host cell furin or another cellular protease to yield the mature S1 and S2 proteins. Additionally, a second cleavage leads to the release of a fusion peptide after viral attachment to host cell receptor.UniRule annotation
The cytoplasmic Cys-rich domain is palmitoylated. Spike glycoprotein is digested within host endosomes.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei749 – 750CleavageBy similarity2
Sitei884 – 885CleavageUniRule annotation2

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q0Q4F2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer; each monomer consists of a S1 and a S2 subunit. The resulting peplomers protrude from the virus surface as spikes.

UniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni372 – 611Receptor-binding domainUniRule annotationAdd BLAST240
Regioni855 – 875Fusion peptideUniRule annotationAdd BLAST21
Regioni991 – 1041Heptad repeat 1UniRule annotationAdd BLAST51
Regioni1245 – 1284Heptad repeat 2UniRule annotationAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1020 – 1064UniRule annotationAdd BLAST45
Coiled coili1257 – 1285UniRule annotationAdd BLAST29

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1348 – 1350KxHxxUniRule annotation3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1312 – 1336Cys-richAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the betacoronaviruses spike protein family.UniRule annotation

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.5.790, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_04099 BETA_CORONA_SPIKE, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR042578 BETA_CORONA_SPIKE
IPR002552 Corona_S2
IPR027400 S_HR2
IPR018548 Spike_rcpt-bd
IPR036326 Spike_rcpt-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01601 Corona_S2, 1 hit
PF09408 Spike_rec_bind, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF143587 SSF143587, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q0Q4F2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRLMCLLMS LSIFVRGFDS QFVDMSPASN ASECLESQVD AAAFSKLVWP 
        60         70         80         90        100
YPIDPAKVDG IIYPLGRTYS NITLEYTGLF PLQGDLGMQY LYSVSHAVGN 
       110        120        130        140        150
DGDPTKAYIS NYSLLVNDFD NGFVVRIGAA ANSTGTIVIS PSVNTKIKKA 
       160        170        180        190        200
YPAFILGSSL TNTSAGKPLY ANYSLTIIPD GCGTVLHAFY CILKPRTGNR 
       210        220        230        240        250
CPSGSDYNAY FIYETIHSDC QSTINRNASL NSFKSFFDLV NCTFFNSWDI 
       260        270        280        290        300
TADETKEWFG ITQDTQGVHL HSSRKGDLYG GNMFRFATLP VYEGIKYYTV 
       310        320        330        340        350
IPRSFRSKAN KREAWAAFYV YKLHQLTYLL DFSVDGYIRR AIDCGHDDLS 
       360        370        380        390        400
QLHCSYTSFE VDTGVYSVSS YEASATGTFI EQPNVTECDF SPMLTGVAPQ 
       410        420        430        440        450
VYNFKRLVFS NCNYNLTKLL SLFAVDEFSC NGISPDAIAR GCYSTLTVDY 
       460        470        480        490        500
FAYPLSMKSY IRPGSAGNIP LYNYKQSFAN PTCRVMASVP DNVTITKPGA 
       510        520        530        540        550
YGYISKCSRL TGVNQDIETP LYINPGEYSI CRDFAPLGFS EDGQVFKRTL 
       560        570        580        590        600
TQFEGGGLLI GVGTRVPMTA NLEMGFVISV QYGTGTDSVC PMLDLGDSLT 
       610        620        630        640        650
ITNRLGKCVD YSLYGVTGRG VFQNCTAVGV KQQRFVYDSF DNLVGYYSDD 
       660        670        680        690        700
GNYYCVRPCV SVPVSVIYDK STNLHATLFG SVACEHVTTM MSQFSRLTQS 
       710        720        730        740        750
NLRRRDSNTP LQTAVGCVIG LSNNSLVVSD CKLPLGQSLC AVPPVSMFRS 
       760        770        780        790        800
YSASQFQLAV LNYTSPIVVT PINSSGFTAA IPTNFSFSLT QEYIETSIQK 
       810        820        830        840        850
VTVDCKQYVC NGFTRCEKLL VEYGQFCSKI NQALHGANLR QDESVYSLYS 
       860        870        880        890        900
NIKTTSTQTL EYGLNGDFNL TLLQVPQIGG SSYRSAIEDL LFDKVTIADP 
       910        920        930        940        950
GYMQGYDDCM KQGPQSARDL ICAQYVSGYK VLPPLYDPNM EAAYTSSLLG 
       960        970        980        990       1000
SIAGAGWTAG LSSFAAIPFA QSMFYRLNGV GITQQVLSEN QKLIANKFNQ 
      1010       1020       1030       1040       1050
ALGAMQTGFT TSNLAFSKVQ DAVNANAQAL SKLASELSNT FGAISSSISD 
      1060       1070       1080       1090       1100
ILARLDTVEQ DAQIDRLING RLTSLNAFVS QQLVRSETAA RSAQLASDKV 
      1110       1120       1130       1140       1150
NECVKSQSKR NGFCGSGTHI VSFVVNAPNG FYFFHVGYVP TNYTNVTAAY 
      1160       1170       1180       1190       1200
GLCNHNNPPL CIAPIDGYFI TNQTTTYSVD TEWYYTGSSF FKPEPITQAN 
      1210       1220       1230       1240       1250
SRYVSSDVKF EKLENNLPPP LLENSTDVDF KDELEEFFKN VTSHGPNFAE 
      1260       1270       1280       1290       1300
ISKINTTLLD LSDEMAILQE VVKQLNDSYI DLKELGNYTY YNKWPWYIWL 
      1310       1320       1330       1340       1350
GFIAGLVALL LCVFFLLCCT GCGTSCLGKM KCKNCCDSYE EYDVEKIHVH
Length:1,350
Mass (Da):148,870
Last modified:September 5, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i33E051F5A646A74D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ648794 Genomic RNA Translation: ABG47052.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ648794 Genomic RNA Translation: ABG47052.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PRIDEiQ0Q4F2

Family and domain databases

Gene3Di1.20.5.790, 1 hit
HAMAPiMF_04099 BETA_CORONA_SPIKE, 1 hit
InterProiView protein in InterPro
IPR042578 BETA_CORONA_SPIKE
IPR002552 Corona_S2
IPR027400 S_HR2
IPR018548 Spike_rcpt-bd
IPR036326 Spike_rcpt-bd_sf
PfamiView protein in Pfam
PF01601 Corona_S2, 1 hit
PF09408 Spike_rec_bind, 1 hit
SUPFAMiSSF143587 SSF143587, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPIKE_BC133
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0Q4F2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: September 5, 2006
Last modified: February 26, 2020
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again