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Protein

Protein 3

Gene

3

Organism
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. Up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. Induces apoptosis in cell culture. Downregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination (By similarity).By similarity

Miscellaneous

Bat coronavirus 279/2005 is highly similar to SARS-CoV (SARS-like).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei133Involved in polymerizationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Viral ion channel
Biological processApoptosis, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein 3
Alternative name(s):
Accessory protein 3
Gene namesi
ORF Names:3
OrganismiBat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
Taxonomic identifieri389167 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostiRhinolophus macrotis (Big-eared horseshoe bat) [TaxID: 196889]
Proteomesi
  • UP000006573 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularBy similarityAdd BLAST34
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 78CytoplasmicSequence analysisAdd BLAST23
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 104ExtracellularSequence analysis5
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 274CytoplasmicBy similarityAdd BLAST149

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host cytoplasm, Host Golgi apparatus, Host membrane, Membrane, Secreted, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002898871 – 274Protein 3Add BLAST274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27O-linked (GalNAc...) serine; by hostSequence analysis1
Glycosylationi28O-linked (GalNAc...) threonine; by hostBy similarity1
Glycosylationi32O-linked (GalNAc...) threonine; by hostBy similarity1
Glycosylationi34O-linked (GalNAc...) threonine; by hostSequence analysis1

Post-translational modificationi

Exists in both O-glycosylated and non-glycosylated forms. The glycosylated form is associated with the virion (By similarity).By similarity

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homotetramer composed of two homodimers linked non covalently. Interacts with M, S and E proteins. Also interacts with the accessory protein 7a (By similarity).By similarity

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi83 – 86Poly-Leu4
Compositional biasi94 – 97Poly-Leu4
Compositional biasi267 – 270Poly-Thr4

Domaini

The second or the third transmembrane region are responsible for Golgi localization.By similarity

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000JI

Family and domain databases

InterProiView protein in InterPro
IPR024407 SARS_coronavirus_Orf3/3a
PfamiView protein in Pfam
PF11289 APA3_viroporin, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD719245 PD719245, 1 hit

Sequencei

Sequence statusi: Complete.

Q0Q474-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLFMSIFTL GAITRQPAKV ENASPASTVH ATATIPLQAS LPFGWLVVGV
60 70 80 90 100
ALLAVFQSAS KVIALHKRWQ LALYKGIQFV CNLLLLFVTI YSHLLLLAAG
110 120 130 140 150
MEAQFLYIYA LIYILQIVSF CRFIMRCWLC WKCRSKNPLL YDANYFVCWH
160 170 180 190 200
TNCFDYCIPY NSITDTIVLT SGDGTTQPKL KEDYQIGGYS EDWHSGVKDY
210 220 230 240 250
VVIHGYFTEI YYQLESTQLS TDTGAENATF FIYSKLVKDV DHVQIHTIDG
260 270
SSGVVNPAMD PIYDEPTTTT SVPL
Length:274
Mass (Da):30,854
Last modified:September 5, 2006 - v1
Checksum:iCE4B26F0262F6D86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ648857 Genomic RNA Translation: ABG47070.1

Similar proteinsi

Entry informationi

Entry nameiAP3A_BC279
AccessioniPrimary (citable) accession number: Q0Q474
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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