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Protein

Envelope small membrane protein

Gene

E

Organism
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.UniRule annotation

Miscellaneous

Bat coronavirus 279/2005 is highly similar to SARS-CoV (SARS-like).

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope small membrane proteinUniRule annotation
Short name:
E proteinUniRule annotation
Short name:
sM proteinUniRule annotation
Gene namesi
Name:EUniRule annotation
Synonyms:sM
ORF Names:4
OrganismiBat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
Taxonomic identifieri389167 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostiRhinolophus macrotis (Big-eared horseshoe bat) [TaxID: 196889]
Proteomesi
  • UP000006573 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16Virion surfaceUniRule annotationAdd BLAST16
Transmembranei17 – 37HelicalUniRule annotationAdd BLAST21
Topological domaini38 – 76IntravirionUniRule annotationAdd BLAST39

GO - Cellular componenti

Keywords - Cellular componenti

Host Golgi apparatus, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002899311 – 76Envelope small membrane proteinAdd BLAST76

Interactioni

Subunit structurei

Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.UniRule annotation

Structurei

3D structure databases

SMRiQ0Q473
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the betacoronaviruses E protein family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG0900022Z

Family and domain databases

HAMAPiMF_04204 BETA_CORONA_E, 1 hit
InterProiView protein in InterPro
IPR003873 NS3/E
PfamiView protein in Pfam
PF02723 NS3_envE, 1 hit

Sequencei

Sequence statusi: Complete.

Q0Q473-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYSFVSEETG TLIVNSVLLF FAFVVFLLVT LAILTALRLC AYCCNIVNVS
60 70
LVKPTVYVYS RVKNLNSSEG VPDLLV
Length:76
Mass (Da):8,395
Last modified:September 5, 2006 - v1
Checksum:i5CD9A91C52DDA199
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ648857 Genomic RNA Translation: ABG47071.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ648857 Genomic RNA Translation: ABG47071.1

3D structure databases

SMRiQ0Q473
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG0900022Z

Family and domain databases

HAMAPiMF_04204 BETA_CORONA_E, 1 hit
InterProiView protein in InterPro
IPR003873 NS3/E
PfamiView protein in Pfam
PF02723 NS3_envE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVEMP_BC279
AccessioniPrimary (citable) accession number: Q0Q473
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 5, 2006
Last modified: June 20, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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