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Protein

Membrane protein

Gene

M

Organism
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.UniRule annotation

Miscellaneous

Bat coronavirus 512/2005 is highly similar to porcine epidemic diarrhea virus (PEDV).

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane proteinUniRule annotation
Short name:
M proteinUniRule annotation
Alternative name(s):
E1 glycoproteinUniRule annotation
Matrix glycoproteinUniRule annotation
Membrane glycoproteinUniRule annotation
Gene namesi
Name:MUniRule annotation
ORF Names:5
OrganismiBat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005)
Taxonomic identifieri693999 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeAlphacoronavirus
Virus hostiScotophilus kuhlii (Lesser asiatic yellow bat) [TaxID: 153297]
Proteomesi
  • UP000113079 Componenti: Genome

Subcellular locationi

  • Virion membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
  • Host Golgi apparatus membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
  • Note: Largely embedded in the lipid bilayer.UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12Virion surfaceUniRule annotationAdd BLAST12
Transmembranei13 – 33HelicalUniRule annotationAdd BLAST21
Topological domaini34 – 42IntravirionUniRule annotation9
Transmembranei43 – 63HelicalUniRule annotationAdd BLAST21
Topological domaini64 – 76Virion surfaceUniRule annotationAdd BLAST13
Transmembranei77 – 97HelicalUniRule annotationAdd BLAST21
Topological domaini98 – 227IntravirionUniRule annotationAdd BLAST130

GO - Cellular componenti

Keywords - Cellular componenti

Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Viral matrix protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002899351 – 227Membrane proteinAdd BLAST227

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni201 – 217Interaction with N proteinUniRule annotationAdd BLAST17

Sequence similaritiesi

Belongs to the alphacoronaviruses M protein family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

HAMAPiMF_04201 ALPHA_CORONA_M, 1 hit
InterProiView protein in InterPro
IPR002574 Corona_M
PfamiView protein in Pfam
PF01635 Corona_M, 1 hit

Sequencei

Sequence statusi: Complete.

Q0Q463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNQSVPVE EVIKHLRNWN FSWNIILTIL LVVLQYGHYK YSRVLYGLKM
60 70 80 90 100
AILWLLWPLV LALSIFDAWA SFNVNWVFFA FSILMACVTA VLWIMYFVNS
110 120 130 140 150
IRLWRRTHSW WSYNPETDSI LSVSVLGRHV CLPILGAPTG VTLTLLNGTL
160 170 180 190 200
LVEGYQVATG VQVNNLPGYV TVAKASTTIV YQRVGRSMNA NSSTGWAFFV
210 220
KSKHGDYYAA ANPTEVVTDS EKILHLV
Length:227
Mass (Da):25,666
Last modified:September 5, 2006 - v1
Checksum:i41CFA6EFC2BB303D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ648858 Genomic RNA Translation: ABG47081.1
RefSeqiYP_001351687.1, NC_009657.1

Genome annotation databases

GeneIDi11266521
KEGGivg:11266521

Similar proteinsi

Entry informationi

Entry nameiVME1_BC512
AccessioniPrimary (citable) accession number: Q0Q463
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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