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Protein

Nucleoprotein

Gene

N

Organism
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.UniRule annotation

Miscellaneous

Bat coronavirus 512/2005 is highly similar to porcine epidemic diarrhea virus (PEDV).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding, Viral nucleoprotein
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
NucleoproteinUniRule annotation
Alternative name(s):
Nucleocapsid proteinUniRule annotation
Short name:
NCUniRule annotation
Short name:
Protein NUniRule annotation
Gene namesi
Name:NUniRule annotation
ORF Names:6
OrganismiBat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005)
Taxonomic identifieri693999 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeAlphacoronavirus
Virus hostiScotophilus kuhlii (Lesser asiatic yellow bat) [TaxID: 153297]
Proteomesi
  • UP000113079 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host endoplasmic reticulum-Golgi intermediate compartment UniRule annotation
  • Host Golgi apparatus UniRule annotation
  • Note: Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host Golgi apparatus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002898841 – 394NucleoproteinAdd BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei145Phosphoserine; by hostUniRule annotation1

Post-translational modificationi

ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.UniRule annotation
Phosphorylated on serine and threonine residues.UniRule annotation

Keywords - PTMi

ADP-ribosylation, Phosphoprotein

Proteomic databases

PRIDEiQ0Q462

Interactioni

Subunit structurei

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ0Q462
SMRiQ0Q462
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni18 – 148RNA-bindingUniRule annotationAdd BLAST131
Regioni236 – 338DimerizationUniRule annotationAdd BLAST103

Sequence similaritiesi

Belongs to the alphacoronavirus nucleocapsid protein family.UniRule annotation

Family and domain databases

HAMAPiMF_04095 ALPHA_CORONA_NCAP, 1 hit
InterProiView protein in InterPro
IPR001218 Corona_nucleocap
IPR037179 Nucleocapsid_C
IPR037195 Nucleocapsid_N
PfamiView protein in Pfam
PF00937 Corona_nucleoca, 1 hit
PIRSFiPIRSF003888 Corona_nucleocap, 1 hit
SUPFAMiSSF103068 SSF103068, 1 hit
SSF110304 SSF110304, 1 hit

Sequencei

Sequence statusi: Complete.

Q0Q462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVKFQPRG RSKGRVPLSL FAPLRVTDEK PLYKVLPNNA VPQGMGGKDQ
60 70 80 90 100
QIGYWVEQQR WRMRRGDRVD LPSNWHFYFL GTGPHSDLPF RKRTDGVFWV
110 120 130 140 150
AIDGAKTQPT GLGVRKSSEK PLVPKFKNKL PNNVEIVEPT TPNNSRANSR
160 170 180 190 200
SRSRGGQSNS RGNSQNRGDK SRNQSRNRSQ SNDRGSDSRD DLVAAVKKAL
210 220 230 240 250
EDLGVGAAKP KGKTQSGKNT PKNKSRSGSV QRAEAKDKPE WRRTPSGDES
260 270 280 290 300
VEVCFGPRGG TRNFGSSEFV AKGVNAPGYA QAASLVPGAA ALLFGGNVAT
310 320 330 340 350
KEMADGVEIT YTYKMLVPKD DKNLEIFLAQ VDAYKLGDPK PQRKVKRSRT
360 370 380 390
PTPKPATEPV YDDVAADPTY ANLEWDTTVE DGVEMINEVF DTQN
Length:394
Mass (Da):43,377
Last modified:September 5, 2006 - v1
Checksum:i1BE30F42AC2411EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ648858 Genomic RNA Translation: ABG47082.1
RefSeqiYP_001351688.1, NC_009657.1

Genome annotation databases

GeneIDi11266522
KEGGivg:11266522

Similar proteinsi

Entry informationi

Entry nameiNCAP_BC512
AccessioniPrimary (citable) accession number: Q0Q462
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 5, 2006
Last modified: June 20, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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