Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-3

Gene

Il3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.UniRule annotation
This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation, Growth factorUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-3UniRule annotation
Short name:
IL-3UniRule annotation
Alternative name(s):
Hematopoietic growth factorUniRule annotation
Mast cell growth factorUniRule annotation
Multipotential colony-stimulating factorUniRule annotation
p-cell-stimulating factorUniRule annotation
Gene namesi
Name:Il3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96552 Il3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500417549227 – 166Interleukin-3Sequence analysisAdd BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 106UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-3 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

HOVERGENiHBG006148

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002183 IL-3
PfamiView protein in Pfam
PF02059 IL3, 1 hit
PIRSFiPIRSF001939 IL-3, 1 hit
PRINTSiPR00430 INTERLEUKIN3
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

Q0PMN2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLASSTTSI HTMLLLLLML FHLGLQASIS GRDTHRLTRT LNCSSIVKEI
60 70 80 90 100
IGKLPEPELK TDDEGPSLRN KSFRRVNLSK FMESQGEVDP EDRYVIKSNL
110 120 130 140 150
QKLNCCLPTS ANDSALPGVF IRDLDDFRKK LRFYMVHLND LETVLTSRPP
160
QPASGSVSPN RGTVEC
Length:166
Mass (Da):18,572
Last modified:September 5, 2006 - v1
Checksum:iE8944CA9F271DBA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ788721 mRNA Translation: ABG81952.1
UniGeneiMm.983

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ788721 mRNA Translation: ABG81952.1
UniGeneiMm.983

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:96552 Il3

Phylogenomic databases

HOVERGENiHBG006148

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002183 IL-3
PfamiView protein in Pfam
PF02059 IL3, 1 hit
PIRSFiPIRSF001939 IL-3, 1 hit
PRINTSiPR00430 INTERLEUKIN3
SUPFAMiSSF47266 SSF47266, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ0PMN2_MOUSE
AccessioniPrimary (citable) accession number: Q0PMN2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: January 31, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again