We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - Q0PM14 (Q0PM14_MOUSE)
Protein
Submitted name:
Mutant TLR6
Gene
Tlr6
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- NAD+ nucleosidase activity Source: InterPro
- transmembrane signaling receptor activity Source: InterPro
GO - Biological processi
- detection of diacyl bacterial lipopeptide Source: InterPro
- inflammatory response Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- MyD88-dependent toll-like receptor signaling pathway Source: InterPro
- positive regulation of cytokine production Source: UniProt
- toll-like receptor 6 signaling pathway Source: InterPro
Keywordsi
Molecular function | ReceptorUniRule annotationARBA annotation |
Biological process | Immunity, Inflammatory responseUniRule annotationARBA annotation, Innate immunityUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Mutant TLR6Imported |
Gene namesi | Name:Tlr6Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:1341296, Tlr6 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 20 – 39 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 596 – 620 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembraneStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 651 – 792 | TIRInterPro annotationAdd BLAST | 142 |
Sequence similaritiesi
Keywords - Domaini
Leucine-rich repeatARBA annotation, RepeatARBA annotation, SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysisFamily and domain databases
Gene3Di | 3.40.50.10140, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000157, TIR_dom IPR027187, TLR6 IPR017241, Toll-like_receptor IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR24365, PTHR24365, 1 hit PTHR24365:SF422, PTHR24365:SF422, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 1 hit PF01582, TIR, 1 hit |
PIRSFi | PIRSF037595, Toll-like_receptor, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 4 hits SM00082, LRRCT, 1 hit SM00255, TIR, 1 hit |
SUPFAMi | SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 2 hits PS50104, TIR, 1 hit |
i Sequence
Sequence statusi: Complete.
Q0PM14-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVKSLWDSLC NMSQDRKPIV GSFHFVCALA LIVGSMTPFS NELESMVDYS
60 70 80 90 100
NRNLTHVPKD LPPRTKALSL SQNSISELRM PDISFLSELR VLRLSHNRIR
110 120 130 140 150
SLDFHVFLFN QDLEYLDVSH NRLQNISCCP MASLRHLDLS FNDFDVLPVC
160 170 180 190 200
KEFGNLTKLT FLGLSAAKFR QLDLLPVAHL HLSCILLDLV SYHIKGGETE
210 220 230 240 250
SLQIPNTTVL HLVFHPNSLF SVQVNMSVNA LGHLQLSNIK LNDENCQRLM
260 270 280 290 300
TFLSELTRGP TLLNVTLQHI ETTWKCSVKL FQFFWPRPVE YLNIYNLTIT
310 320 330 340 350
ERIDREEFTY SETALKSLMI EHVKNQAFLF SKEALYSVFA EMNIKMLSIS
360 370 380 390 400
DTPFIHMVCP PSPSSFTFLN FTQNVFTDSV FQGCSTLKRL QTLILQRNGL
410 420 430 440 450
KNFFKVALMT KNMSSLETLD VSLNSLNSHA YDRTCAWAES ILVLNLSSNM
460 470 480 490 500
LTGSVFRCLP PKVKVLDLHN NRIMSIPKDV THLQALQELN VASNSLTDLP
510 520 530 540 550
GCGAFSSLSV LVIDHNSVSH PSEDFFQSCQ NIRSLTAGNN PFQCTCELRD
560 570 580 590 600
FVKNIGWVAR EVVEGWPDSY RCDYPESSKG TALRDFHMSP LSCDTVLLTI
610 620 630 640 650
TIGATMLVLA VTGAFLCLYF DLPWYVRMLC QWTQTRHRAR HIPLEELQRN
660 670 680 690 700
LQFHAFVSYS EHDSAWVKNE LLPNLEKDDI RVCLHERNFV PGKSIVENII
710 720 730 740 750
NFIEKSYKAI FVLSPHFIQS EWCHYELYFA HHNLFHEGSD NLILILLEPI
760 770 780 790 800
LQNNIPSRYH KLRALMAQRT YLEWPTEKGK RGLFWANLRA SFIMKLALVN
EDDVKT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ790887 mRNA Translation: ABG78745.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ790887 mRNA Translation: ABG78745.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Organism-specific databases
MGIi | MGI:1341296, Tlr6 |
Miscellaneous databases
SOURCEi | Search... |
Family and domain databases
Gene3Di | 3.40.50.10140, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000157, TIR_dom IPR027187, TLR6 IPR017241, Toll-like_receptor IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR24365, PTHR24365, 1 hit PTHR24365:SF422, PTHR24365:SF422, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 1 hit PF01582, TIR, 1 hit |
PIRSFi | PIRSF037595, Toll-like_receptor, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 4 hits SM00082, LRRCT, 1 hit SM00255, TIR, 1 hit |
SUPFAMi | SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 2 hits PS50104, TIR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q0PM14_MOUSE | |
Accessioni | Q0PM14Primary (citable) accession number: Q0PM14 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 5, 2006 |
Last sequence update: | September 5, 2006 | |
Last modified: | May 25, 2022 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |