Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Caspase 2

Gene

casp2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • intrinsic apoptotic signaling pathway in response to DNA damage Source: ZFIN
  • positive regulation of apoptotic process Source: ZFIN
  • regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: ZFIN

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation

Enzyme and pathway databases

ReactomeiR-DRE-168638 NOD1/2 Signaling Pathway
R-DRE-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases

Protein family/group databases

MEROPSiC14.006

Names & Taxonomyi

Protein namesi
Submitted name:
Caspase 2Imported
Submitted name:
Caspase 2, apoptosis-related cysteine peptidaseImported
Submitted name:
Caspase 2, apoptosis-related cysteine proteaseImported
Gene namesi
Name:casp2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-030825-3 casp2

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSDARG00000062052 Expressed in 23 organ(s), highest expression level in testis

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 97CARDInterPro annotationAdd BLAST91
Domaini165 – 292CASPASE_P20InterPro annotationAdd BLAST128
Domaini336 – 429CASPASE_P10InterPro annotationAdd BLAST94

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00760000118912
HOGENOMiHOG000290714
HOVERGENiHBG103962
KOiK02186
OrthoDBiEOG091G05YD

Family and domain databases

CDDicd00032 CASc, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR029030 Caspase-like_dom_sf
IPR035702 Caspase_2
IPR033139 Caspase_cys_AS
IPR016129 Caspase_his_AS
IPR011029 DEATH-like_dom_sf
IPR002138 Pept_C14_p10
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A
PANTHERiPTHR10454:SF151 PTHR10454:SF151, 1 hit
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PRINTSiPR00376 IL1BCENZYME
SMARTiView protein in SMART
SM00114 CARD, 1 hit
SM00115 CASc, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52129 SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS01122 CASPASE_CYS, 1 hit
PS01121 CASPASE_HIS, 1 hit
PS50207 CASPASE_P10, 1 hit
PS50208 CASPASE_P20, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

Q0PKX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGECGMTKW ERLALRRNSV KMLQDLVVDD LLIQCLQQDG ILTDSMAESI
60 70 80 90 100
MAKPTSQGRS HQLLFLLPKR GPRAFSTFCS ALKETEQHHL CKLLMDFTEK
110 120 130 140 150
DKCFSEPSLS LPTQECVTPA KRPRTHESME MCLDADSPVT TAVLPCTPEF
160 170 180 190 200
YQSHRPQAYP MRSCPRGLAL VLSNVRFDSA NTDLDIRRGG EVDEETLRRL
210 220 230 240 250
FTELDFKVSL HRDLTAEAMR RCLEQFAQQQ EHAAYDCAVV CLLSHGVEGS
260 270 280 290 300
VYGTDGQLLE LDWVFEVFDN ARCPLLQNKP KMFFIQACRG EEMDNGVDQL
310 320 330 340 350
DGQERTQSPG CEQRDAGREG ERDNREKKEE KERERLRVKL PQRSDMICGF
360 370 380 390 400
ATLKGTAAMR NTKKGSWFIQ ELNTAIRQRA NNTHLSDILV QVNGQIKSRE
410 420 430
GYAPGSAHHR CKEMSEFTSS LCKDLYLFPK YYPSN
Length:435
Mass (Da):49,577
Last modified:September 5, 2006 - v1
Checksum:i49C94030D66C17CB
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A288CG41A0A288CG41_DANRE
Caspase 2
casp2
437Annotation score:
A6H8R3A6H8R3_DANRE
Casp2 protein
casp2
399Annotation score:
F1Q9Y1F1Q9Y1_DANRE
Caspase 2, apoptosis-related cystei...
casp2
242Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR855317 Genomic DNA No translation available.
FP015958 Genomic DNA No translation available.
BC163115 mRNA Translation: AAI63115.1
BC163139 mRNA Translation: AAI63139.1
DQ812119 mRNA Translation: ABG91569.1
RefSeqiNP_001036160.1, NM_001042695.1
XP_009290451.1, XM_009292176.2
UniGeneiDr.162020

Genome annotation databases

EnsembliENSDART00000186475; ENSDARP00000148777; ENSDARG00000062052
GeneIDi373118
KEGGidre:373118

Similar proteinsi

Entry informationi

Entry nameiQ0PKX3_DANRE
AccessioniPrimary (citable) accession number: Q0PKX3
Secondary accession number(s): E7F2V8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: September 12, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again