UniProtKB - Q0PGW2 (DEN11_RAT)
Protein
DENN domain-containing protein 11
Gene
Dennd11
Organism
Rattus norvegicus (Rat)
Status
Functioni
Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia.Curated1 Publication
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
Keywordsi
Molecular function | Guanine-nucleotide releasing factor |
Names & Taxonomyi
Protein namesi | Recommended name: DENN domain-containing protein 11CuratedShort name: DENND11 Alternative name(s): Protein LCHN1 Publication |
Gene namesi | Name:Dennd11 Synonyms:Lchn1 Publication |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1563986, RGD1563986 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000315223 | 2 – 455 | DENN domain-containing protein 11Add BLAST | 454 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylvalineBy similarity | 1 | |
Modified residuei | 41 | Omega-N-methylarginineBy similarity | 1 |
Keywords - PTMi
Acetylation, MethylationProteomic databases
jPOSTi | Q0PGW2 |
PaxDbi | Q0PGW2 |
PRIDEi | Q0PGW2 |
PTM databases
SwissPalmi | Q0PGW2 |
Expressioni
Tissue specificityi
Expressed within the somatodendritic compartment of neurons, is also present on dendritic growth cones, but is not found in astrocytes.1 Publication
Inductioni
By transient cerebral ischemia.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000011854, Expressed in cerebellum and 19 other tissues |
Interactioni
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000015921 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 187 | uDENNPROSITE-ProRule annotationAdd BLAST | 173 | |
Domaini | 214 – 362 | cDENNPROSITE-ProRule annotationAdd BLAST | 149 | |
Domaini | 364 – 455 | dDENNPROSITE-ProRule annotationAdd BLAST | 92 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 276 – 279 | Poly-Cys | 4 |
Sequence similaritiesi
Belongs to the DENND11 family.Curated
Phylogenomic databases
eggNOGi | KOG4704, Eukaryota |
GeneTreei | ENSGT00590000083189 |
HOGENOMi | CLU_049607_0_0_1 |
InParanoidi | Q0PGW2 |
OMAi | NDQRQML |
OrthoDBi | 1439536at2759 |
PhylomeDBi | Q0PGW2 |
TreeFami | TF329174 |
Family and domain databases
InterProi | View protein in InterPro IPR018626, LCHN/Anr2 IPR037516, Tripartite_DENN |
Pfami | View protein in Pfam PF09804, DENND11, 1 hit |
PROSITEi | View protein in PROSITE PS50211, DENN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q0PGW2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVEQGDAAPL LRWAEGPAVS VPQDPALQAG GWVRGGSGGG RVAAEAPRRR
60 70 80 90 100
EPEEPAPPEV LLQPGRLELG DVEEDQVVAV FVVTFDPRSG NMVEWCLPQD
110 120 130 140 150
IDLEGVEFKS MASGSHKVQS DFIYFRKGPF FGLACFANMP VESELERGAR
160 170 180 190 200
MKSVGILSPS YTLLYRYMHF LENQVRHQLE MPGHYSHLAA FYEDKKGVLH
210 220 230 240 250
AGPGRGGSLP PVYWLPSIHR YMYPEMKITH PAGCMSQFIK FFGEQILILW
260 270 280 290 300
KFALLRKRIL IFSPPPVGVV CYRVYCCCCL ANVSLPGIGG TIPESKPFFY
310 320 330 340 350
VNVADIESLE VEVSYVACTT EKIFEEKREL YDVYVDNQNV KTHHDHLQPL
360 370 380 390 400
LKLNSADREK YRRLNEQRQM LLYSQEVEGD YSPCEEDLFV LFFLEQNNRI
410 420 430 440 450
FQTLLEVSAS QDKTLTAEHA RGMGLDPQGD RSFLMDLLEA YGIDVMLVID
NPCCP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ836251 mRNA Translation: ABH04324.1 |
RefSeqi | NP_001038166.1, NM_001044701.1 XP_006236423.2, XM_006236361.3 |
Genome annotation databases
Ensembli | ENSRNOT00000015921; ENSRNOP00000015921; ENSRNOG00000011854 |
GeneIDi | 312270 |
KEGGi | rno:312270 |
UCSCi | RGD:1563986, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ836251 mRNA Translation: ABH04324.1 |
RefSeqi | NP_001038166.1, NM_001044701.1 XP_006236423.2, XM_006236361.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000015921 |
PTM databases
SwissPalmi | Q0PGW2 |
Proteomic databases
jPOSTi | Q0PGW2 |
PaxDbi | Q0PGW2 |
PRIDEi | Q0PGW2 |
Genome annotation databases
Ensembli | ENSRNOT00000015921; ENSRNOP00000015921; ENSRNOG00000011854 |
GeneIDi | 312270 |
KEGGi | rno:312270 |
UCSCi | RGD:1563986, rat |
Organism-specific databases
CTDi | 57189 |
RGDi | 1563986, RGD1563986 |
Phylogenomic databases
eggNOGi | KOG4704, Eukaryota |
GeneTreei | ENSGT00590000083189 |
HOGENOMi | CLU_049607_0_0_1 |
InParanoidi | Q0PGW2 |
OMAi | NDQRQML |
OrthoDBi | 1439536at2759 |
PhylomeDBi | Q0PGW2 |
TreeFami | TF329174 |
Miscellaneous databases
PROi | PR:Q0PGW2 |
Gene expression databases
Bgeei | ENSRNOG00000011854, Expressed in cerebellum and 19 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR018626, LCHN/Anr2 IPR037516, Tripartite_DENN |
Pfami | View protein in Pfam PF09804, DENND11, 1 hit |
PROSITEi | View protein in PROSITE PS50211, DENN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DEN11_RAT | |
Accessioni | Q0PGW2Primary (citable) accession number: Q0PGW2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | September 5, 2006 | |
Last modified: | October 7, 2020 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families