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Entry version 87 (08 May 2019)
Sequence version 2 (23 Oct 2007)
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Protein

Coiled-coil domain-containing protein 15

Gene

CCDC15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25798 CCDC15

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q0P6D6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000149548

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672175

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC15

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160017591

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003077151 – 951Coiled-coil domain-containing protein 15Add BLAST951

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q0P6D6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q0P6D6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q0P6D6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q0P6D6

PeptideAtlas

More...
PeptideAtlasi
Q0P6D6

PRoteomics IDEntifications database

More...
PRIDEi
Q0P6D6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58778

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q0P6D6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q0P6D6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000149548 Expressed in 130 organ(s), highest expression level in oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q0P6D6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q0P6D6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040450
HPA041738

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123101, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q0P6D6, 1 interactor

Molecular INTeraction database

More...
MINTi
Q0P6D6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000341684

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili64 – 89Sequence analysisAdd BLAST26
Coiled coili154 – 193Sequence analysisAdd BLAST40
Coiled coili782 – 813Sequence analysisAdd BLAST32
Coiled coili839 – 874Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi313 – 316Poly-Glu4

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKKY Eukaryota
ENOG410Z3J8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000044966

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111403

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q0P6D6

KEGG Orthology (KO)

More...
KOi
K16752

Database of Orthologous Groups

More...
OrthoDBi
489797at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q0P6D6

TreeFam database of animal gene trees

More...
TreeFami
TF329047

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037693 CCDC15

The PANTHER Classification System

More...
PANTHERi
PTHR14817 PTHR14817, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q0P6D6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGSMARKKP RNTSRLPLAL NPLKSKDVLA VLAERNEAIV PVGAWVEPAS
60 70 80 90 100
PGSSEIPAYT SAYLIEEELK EQLRKKQEAL KHFQKQVKYR VNQQIRLRKK
110 120 130 140 150
QQLQKSYERA QKEGSIAMQS SATHLTSKRT SVFPNNLNVA IGSSRLPPSL
160 170 180 190 200
MPGDGIEDEE NQNELFQQQA QALSETMKQA RHRLASFKTV IKKKGSVFPD
210 220 230 240 250
DGRKSFLTRE EVLSRKPAST GINTGIRGEL PIKVHQGLLA AVPYQNYMEN
260 270 280 290 300
QELDYEEPDY EESSSLVTDE KGKEDLFGRG QQDQQAIHSE DKNKPFSRVQ
310 320 330 340 350
KVKFKNPLFV LMEEEEQKQL HFEGLQDILP EAQDYFLEAQ GDLLETQGDL
360 370 380 390 400
TGIQSVKPDT QAVEMKVQVT EPEGQAIEPE GQPIKTETQG IMLKAQSIEL
410 420 430 440 450
EEGSIVLKTQ DFLPTNQALL TKNQDVLLKD HCVLPKDQSI LLKYQDQDFL
460 470 480 490 500
PRDQHVLHKD QDILPKYQDQ NFLPKDQNFL SRDQHVLPKD QDILPKYQDQ
510 520 530 540 550
NFLPKDQNFL SRDQHVLPKD QNILPKYQGQ DFLPKDQDFL SRDQHVLPKD
560 570 580 590 600
WNILPKCQDQ DFLPRDQGVL PKDQNILPIC QDQDFLPRDQ GYLPKDQNIL
610 620 630 640 650
PICQDRDFLP RDLHVLSNDQ NILPKCQDQD FLPKYQKVHF KEPYSDMTDE
660 670 680 690 700
KGREDFSLAD YQCLPPKSQD QDDIKNQQPA SFMREERVRE ELPLDYHQYV
710 720 730 740 750
VPKIQDQDSP REQNKHIKLP SSFEKWEIAR GNTPGVPLAY DRYQSGLSTE
760 770 780 790 800
FQAPLAFQSD VDKEEDKKER QKQYLRHRRL FMDIEREQVK EQQRQKEQKK
810 820 830 840 850
KIEKIKKKRE QECYAAEQRI LRMNFHEDPY SGEKLSEILA QLQLQEIKGT
860 870 880 890 900
REKQQREKEY LRYVEALRAQ IQEKMQLYNI TLPPLCCCGP DFWDAHPDTC
910 920 930 940 950
ANNCIFYKNH RAYTRALHSF INSCDVPGGN STLRVAIHNF ASAHRRTLKN

L
Length:951
Mass (Da):110,484
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9E832C87CA5E580
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PKB1E9PKB1_HUMAN
Coiled-coil domain-containing prote...
CCDC15
962Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH18540 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti385K → R in BAB14504 (PubMed:14702039).Curated1
Sequence conflicti450L → P in BAB14504 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069401166F → C1 Publication1
Natural variantiVAR_050748529G → D. Corresponds to variant dbSNP:rs4936966Ensembl.1
Natural variantiVAR_050749813C → R. Corresponds to variant dbSNP:rs7107487Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AP003501 Genomic DNA No translation available.
BC018540 mRNA Translation: AAH18540.1 Sequence problems.
AK023277 mRNA Translation: BAB14504.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44756.1

NCBI Reference Sequences

More...
RefSeqi
NP_079280.2, NM_025004.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000344762; ENSP00000341684; ENSG00000149548

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80071

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80071

UCSC genome browser

More...
UCSCi
uc001qbm.6 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003501 Genomic DNA No translation available.
BC018540 mRNA Translation: AAH18540.1 Sequence problems.
AK023277 mRNA Translation: BAB14504.1
CCDSiCCDS44756.1
RefSeqiNP_079280.2, NM_025004.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi123101, 5 interactors
IntActiQ0P6D6, 1 interactor
MINTiQ0P6D6
STRINGi9606.ENSP00000341684

PTM databases

iPTMnetiQ0P6D6
PhosphoSitePlusiQ0P6D6

Polymorphism and mutation databases

BioMutaiCCDC15
DMDMi160017591

Proteomic databases

EPDiQ0P6D6
jPOSTiQ0P6D6
MaxQBiQ0P6D6
PaxDbiQ0P6D6
PeptideAtlasiQ0P6D6
PRIDEiQ0P6D6
ProteomicsDBi58778

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344762; ENSP00000341684; ENSG00000149548
GeneIDi80071
KEGGihsa:80071
UCSCiuc001qbm.6 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80071

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC15
HGNCiHGNC:25798 CCDC15
HPAiHPA040450
HPA041738
neXtProtiNX_Q0P6D6
OpenTargetsiENSG00000149548
PharmGKBiPA142672175

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKKY Eukaryota
ENOG410Z3J8 LUCA
GeneTreeiENSGT00500000044966
HOGENOMiHOG000111403
InParanoidiQ0P6D6
KOiK16752
OrthoDBi489797at2759
PhylomeDBiQ0P6D6
TreeFamiTF329047

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80071

Protein Ontology

More...
PROi
PR:Q0P6D6

Gene expression databases

BgeeiENSG00000149548 Expressed in 130 organ(s), highest expression level in oocyte
ExpressionAtlasiQ0P6D6 baseline and differential
GenevisibleiQ0P6D6 HS

Family and domain databases

InterProiView protein in InterPro
IPR037693 CCDC15
PANTHERiPTHR14817 PTHR14817, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCD15_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0P6D6
Secondary accession number(s): Q9H8U7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: May 8, 2019
This is version 87 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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